The TL1A-DR3 Axis in Asthma: Membrane-Bound and Secreted TL1A Co-Determined the Development of Airway Remodeling

CONCLUSIONS: Our results confirm differential TL1A expression (including its secreted and non-secreted form) in asthma, which modulates remodeling. The shared mechanism of action by which nsTL1A and secreted TL1A exert their effects on asthma development might be mediated via the nuclear factor-κB pathway. The TL1A-DR3 axis presents a promising therapeutic target in asthma.PMID:35255540 | DOI:10.4168/aair.2022.14.2.233
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Authors: Source Type: research