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Specialty: Cancer & Oncology
Cancer: Bone Cancers

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Total 114 results found since Jan 2013.

Upregulated LEPRE1 correlates with poor outcome and its knockdown attenuates cells proliferation, migration and invasion in osteosarcoma
In conclusion, leucine proline-enriched proteoglycan 1 might function as an important therapeutic factor in human osteosarcoma through regulating the PI3K/AKT signaling pathway.
Source: Anti-Cancer Drugs - March 14, 2020 Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research

IL-6 Promotes Cancer Stemness and Oncogenicity in U2OS and MG-63 Osteosarcoma Cells by Upregulating the OPN-STAT3 Pathway
Conclusions: IL-6 mediates promotion of osteosarcoma spheroid stemness by activating OPN/STAT3 signaling.
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Chuan Zhang, Kun Ma, Wu-Yin Li Tags: Research Paper Source Type: research

Knockdown of Ski decreases osteosarcoma cell proliferation and migration by suppressing the PI3K/Akt signaling pathway.
In this study, firstly the differential expression of Ski in OS tissues and osteochondroma tissues was detected, and the expression of Ski in both human OS cell lines (MG63 and U2OS) and normal osteoblasts (hFoB1.19) was then detected. The results demonstrated that Ski expression was significantly upregulated in both human OS tissues and cell lines. The results led us to hypothesize that Ski may play an essential role in the pathological process of OS. Thus, Ski specific small interfere RNA (Ski‑siRNA) was used. The results revealed that OS cell proliferation was markedly inhibited following the knockdown of Ski, which w...
Source: International Journal of Oncology - November 13, 2019 Category: Cancer & Oncology Authors: Zhao X, Fang Y, Wang X, Yang Z, Li D, Tian M, Kang P Tags: Int J Oncol Source Type: research

The tetraspanin CD81 mediates the growth and metastases of human osteosarcoma
ConclusionBased on our findings we conclude that inhibition of CD81 suppresses intracellular signaling and reduces tumorigenesis and lung metastasis in osteosarcoma cells.
Source: Cellular Oncology - September 6, 2019 Category: Cancer & Oncology Source Type: research

AUF1 positively controls angiogenesis through mRNA stabilization-dependent up-regulation of HIF-1 α and VEGF-A in human osteosarcoma.
AUF1 positively controls angiogenesis through mRNA stabilization-dependent up-regulation of HIF-1α and VEGF-A in human osteosarcoma. Oncotarget. 2019 Aug 06;10(47):4868-4879 Authors: Al-Khalaf HH, Aboussekhra A Abstract Osteosarcoma is the most common malignant bone tumor in children, adolescents, and young adults. This pleiomorphic tumor depends on new blood vessel development, also known as angiogenesis, for tumor growth and metastasis. Therefore, it's of utmost importance to identify the key genes and pathways that regulate this pro-metastatic process in order to develop more efficient therapies. H...
Source: Oncotarget - August 28, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

BTF3 Silencing Inhibits the Proliferation of Osteosarcoma Cells
Osteosarcoma (OS) is one of the bone malignancy cancers with poor prognosis in the early stages worldwide. Basic transcription factor 3 (BTF3) is associated with the development of several types of cancer. The present study aimed to evaluate the role of BTF3 in OS. Silencing of BTF3 was achieved by using stable lentivirus transfection of siRNA targeting BTF3 in the human OS cell line Saos-2. Cell viability and colony-forming ability were measured using methyl-thaizolyl-tetrazolium (MTT) and colony formation assays, respectively. Propidium iodide staining and flow cytometry was used to detect the progression of the cell cyc...
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Qi Liu, Lin Jiang, Wanchun Wang, Tao Jiang Tags: Research Paper Source Type: research

CBX2 is a functional target of miRNA let ‐7a and acts as a tumor promoter in osteosarcoma
Our study demonstrates that let ‐7a/CBX2 plays a crucial role in osteosarcoma progression. CBX2 could serve as a promising prognostic biomarker and potential therapeutic target for osteosarcoma patients. AbstractOsteosarcoma is the most common type of primary malignant tumor of skeletal with poor prognosis in children and adolescents. Accumulating evidence indicates that CBX2 is overexpressed in multiple human neoplasm and play a critical role in tumorigenesis and progression. However, its functional role and upstream regulation mechanism in osteosarcoma remain unknown. In the present study, tissue microarray (TMA) analy...
Source: Cancer Medicine - May 30, 2019 Category: Cancer & Oncology Authors: Qicai Han, Chao Li, Yuan Cao, Jie Bao, Kongfei Li, Ruipeng Song, Xiaolong Chen, Juan Li, Xuejian Wu Tags: ORIGINAL RESEARCH Source Type: research

The nuclear-cytoplasmic trafficking of a chromatin-modifying and remodelling protein (KMT2C), in osteosarcoma.
Authors: Chiappetta C, Puggioni C, Carletti R, Petrozza V, Della Rocca C, Di Crisfofano C Abstract Osteosarcoma is the most common paediatric primary non-hematopoietic bone tumor; the survival is related to the response to chemotherapy and development of metastases. KMT2C is a chromatin-modifying and remodelling protein and its expression has never been studied in osteosarcoma. The aim of this study was to understand the role of KMT2C in the osteosarcoma carcinogenesis and metastatic progression to identify a new molecular target and to provide new therapeutic approach. We performed the immunohistochemical and gene...
Source: Oncotarget - August 11, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Silencing Ubc9 expression suppresses osteosarcoma tumorigenesis and enhances chemosensitivity to HSV-TK/GCV by regulating connexin  43 SUMOylation.
In conclusion, the present study revealed a novel method for the effective restoration of GJIC in osteosarcoma cells, which may increase their sensitivity to conventional chemotherapy. PMID: 29956745 [PubMed - as supplied by publisher]
Source: International Journal of Oncology - June 21, 2018 Category: Cancer & Oncology Authors: Zhang D, Yu K, Yang Z, Li Y, Ma X, Bian X, Liu F, Li L, Liu X, Wu W Tags: Int J Oncol Source Type: research

Focal adhesion kinase promotes progression and predicts poor clinical outcomes in patients with osteosarcoma.
Authors: Gu HJ, Zhou B Abstract Osteosarcoma (OS) is a fatal form of musculoskeletal tumor that commonly leads to pulmonary metastatic disease. Traditional therapies such as surgery and chemotherapy are not effective treatment modalities in certain patients with OS; therefore, identifying the molecular mechanism of OS is imperative for the development of novel therapeutics. Previous studies have reported that focal adhesion kinase (FAK) is associated with numerous types of human malignancies. Therefore, in order to investigate the biological function of FAK in OS, the present study examined the expression levels of...
Source: Oncology Letters - June 1, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

GPNMB silencing suppresses the proliferation and metastasis of osteosarcoma cells by blocking the PI3K/Akt/mTOR signaling pathway.
In conclusion, we provided evidence that GPNMB silencing regulated the proliferation and metastasis of osteosarcoma cells by suppressing the PI3K/Akt/mTOR signaling pathway. Thus, GPNMB may be a potential therapeutic target for osteosarcoma treatment. PMID: 29620278 [PubMed - as supplied by publisher]
Source: Oncology Reports - April 6, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Anticancer effect of (S)-crizotinib on osteosarcoma cells by targeting MTH1 and activating reactive oxygen species
This study aimed to explore the anticancer effect of MTH1-targeted drug (S)-crizotinib on osteosarcoma (OS) cells. We detected MTH1 expression in OS tissues and cells using immunohistochemistry and western blot. The effects of MTH1 on OS cell viability were explored using the siRNA technique and CCK8. The anticancer effects of the MTH1-targeted drug (S)-crizotinib on OS cells were explored by in-vitro assays. The intracellular 8-oxo-dGTP level and oxygen reactive species (ROS) of OS cells were detected by Cy3-conjugated avidin staining and dichlorofluorescein diacetate staining, respectively. The expression of MTH1 was sig...
Source: Anti-Cancer Drugs - March 16, 2018 Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research

Effects of NOB1 on the pathogenesis of osteosarcoma and its expression on the chemosensitivity to cisplatin.
Authors: Luo L, Wang Y, Yin Y, Ge J, Lu X Abstract The effects of NIN1/RPN12 binding protein 1 homolog (NOB1) on the pathogenesis of osteosarcoma and its expression on the chemosensitivity to cisplatin were investigated. Seventy-four patients with osteosarcoma who received surgical resection in The Affiliated Hospital of Southwest Medical University (Sichuan, China) from September 2013 to September 2016 were enrolled in this study. The expression of NOB1 in cancer and cancer-adjacent tissues of patients was detected by reverse transcription-polymerase chain reaction, and the relationship between NOB1 expression and...
Source: Oncology Letters - February 24, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effects of Grb2-associated binding protein 2-specific siRNA on the migration and invasion of MG-63 osteosarcoma cells.
Authors: Wang H, He H, Meng H, Cui Y, Wang W Abstract To investigate the association between the expression of growth factor receptor binding protein 2-associated binding protein 2 (Gab2) in human osteosarcoma as well as the effects of Gab2 on invasion and metastasis, human MG-63 osteosarcoma cells were transfected with small interfering (si)RNA plasmid. Gab2 protein and mRNA expression levels were detected using western blotting and reverse transcription-polymerase chain reaction, respectively. The cell migration and invasion abilities were detected using in vitro chemotaxis and invasion assays, respectively, foll...
Source: Oncology Letters - February 10, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

LIM kinase 1 serves an important role in the multidrug resistance of osteosarcoma cells.
Authors: Yang JZ, Huang LH, Chen R, Meng LJ, Gao YY, Ji QY, Wang Y Abstract Multidrug resistance (MDR) is a major challenge for the management of the majority of cancers. The precise molecular mechanisms of MDR remain elusive. In a previous study, a multidrug resistant osteosarcoma model [MG63/vincristine (VCR)] was established by intermittent exposure of MG63 cells to gradually increasing concentrations of VCR. These cells exhibited cross-resistance to multiple structurally and mechanistically unrelated chemotherapeutic agents. The development of MDR was associated with increased expression of LIM kinase 1 (LIMK1)...
Source: Oncology Letters - February 3, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research