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Research Progress of Metformin in the Treatment of Oral Squamous Cell Carcinoma
Endocrinology. 2023 Sep 20:bqad139. doi: 10.1210/endocr/bqad139. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is one of the most common malignancies with high mortality, posing a great threat to both human physical and mental health. With the advancement of scientific research, a variety of cancer therapies have been used for OSCC treatment. However, the prognosis of OSCC shows no significant improvement. Metformin has been recognized as the first-line drug for the treatment of diabetes, and recent studies have shown that metformin has a remarkable suppressive effect on tumor progression. Metformin can...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Jiayi Liu Jing Zhao Xue Qiao Source Type: research
STAT3-EphA7 axis contributes to the progression of esophageal squamous cell carcinoma
CONCLUSION: Our results showed that the transcriptional expression of EphA7 was increased by activated STAT3, and the STAT3 signaling may act through EphA7 to promote the development of ESCC.PMID:37738252 | DOI:10.1080/0284186X.2023.2259601
Source: Acta Oncologica - September 22, 2023 Category: Cancer & Oncology Authors: Li Wang Qiao-Feng Zhao Bing-Bing Yang Hui-Jie Liang Xian-E Zhang Xiao-Yan Zhang Wan-Jing Yang Zhi-Yu Guo Xin Xu Fang Tian Qing-Hua Wu Source Type: research
Activity of pazopanib in < em > EWSR1-NFATC2 < /em > translocation-associated bone sarcoma
Oncoscience. 2023 Sep 20;10:44-53. doi: 10.18632/oncoscience.587. eCollection 2023.ABSTRACTPazopanib is a multi-kinase inhibitor that is currently approved for treatment of advanced renal cell carcinoma and chemotherapy-refractory soft tissue sarcoma. In this case report, we discuss the case of a patient with a EWSR1-NFATC2 fusion positive bone sarcoma who had exceptional tumor control through using pazopanib and surgery for an overall duration exceeding 5 years. We also review the literature on EWSR1-NFATC2 translocation-associated sarcomas and use of pazopanib in bone sarcomas.PMID:37736255 | PMC:PMC10511123 | DOI:10.18632/oncoscience.587
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Mohamed A Gouda Maria A Zarzour Ara A Vaporciyan Kalevi Kairemo Hubert H Chuang Vivek Subbiah Source Type: research
ORM1 promotes tumor progression of kidney renal clear cell carcinoma (KIRC) through CALR-mediated apoptosis
This study provides us a new way to recognize the development and progression in KIRC.PMID:37735575 | DOI:10.1038/s41598-023-42962-w
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Gang Yu Juan Gao Weifeng Hu Dayong Hu Weibing Wang Shiquan Yang Jing Gao Source Type: research
Galectin-3 Cooperates with CD47 to Suppress Phagocytosis and T cell Immunity in Gastric Cancer Peritoneal Metastases
Cancer Res. 2023 Sep 22. doi: 10.1158/0008-5472.CAN-23-0783. Online ahead of print.ABSTRACTThe peritoneal cavity is a common site of gastric adenocarcinoma (GAC) metastasis. Peritoneal carcinomatosis (PC) is resistant to current therapies and confer poor prognosis, highlighting the need to identify new therapeutic targets. CD47 conveys a "don't eat me" signal to myeloid cells upon binding its receptor SIRPα, which helps tumor cells circumvent macrophage phagocytosis and evade innate immune responses. Previous studies demonstrated that the blockade of CD47 alone results in limited clinical benefits, suggesting that other t...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Yibo Fan Shumei Song Yuan Li Shilpa S Dhar Jiankang Jin Katsuhiro Yoshimura Xiaodan Yao Ruiping Wang Ailing W Scott Melissa Pool Pizzi JingJing Wu Lang Ma George A Calin Samir Hanash Linghua Wang Michael Curran Jaffer A Ajani Source Type: research
Construction of an anoikis ‒related prognostic signature to predict immunotherapeutic response and prognosis in hepatocellular carcinoma
CONCLUSION: A successful anoikis-related prognostic signature and corresponding clinical nomogram were established, which might facilitate better predictions of prognosis and therapeutic responses for HCC patients.PMID:37736789 | DOI:10.1007/s00432-023-05428-0
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Chen Xiong Guoqiang Pan Hanchao Wang Guangxiao Meng Lunjie Yan Ruizhe Li Yuchuan Yan Yafei Yang Xiao Zhang Chuncheng Yang Zhaoru Dong Tao Li Source Type: research
Estimating Remaining Life Expectancy in Veterans with Basal Cell Carcinoma Using an Automated Electronic Health Record Scoring System: A Retrospective Cohort Study
Active surveillance may be considered for low-risk basal cell carcinomas (BCC) in patients with limited life expectancy; however, estimates of life expectancy are not readily available. Veterans Health Administration ’s (VHA) Care Assessment Need (CAN) score may address this problem.
Source: Journal of the American Academy of Dermatology - September 22, 2023 Category: Dermatology Authors: Matthew P. Dizon, Eleni Linos, Susan M. Swetter Source Type: research
Identification of alternative splicing associated with clinical features: from pan-cancers to genitourinary tumors
ConclusionWe demonstrated the significant clinical relevance of ASEs in multiple cancer types. Furthermore, we identified and validated alternative splicing of TUBB3 and RNA binding proteins such as PCBP2 as critical regulators in the progression of urogenital cancers.
Source: Frontiers in Oncology - September 22, 2023 Category: Cancer & Oncology Source Type: research
Needs and Preferences of Patients With Head-neck Cutaneous SCC
Conditions: Cutaneous Squamous Cell Carcinoma; Cutaneous Squamous Cell Carcinoma of the Head and Neck; Squamous Cell Carcinoma; Squamous Cell Carcinoma of Head and Neck; Squamous Cell Carcinoma of the Head and Neck; Skin Cancer; Patient Satisfaction; High-Risk Cance r; Preference, Patient; Decision Making; Interview Intervention: Other: Regular care with additional administration of a semi-structured interview Sponsor: Maastricht University Medical Center Active, not recruiting
Source: ClinicalTrials.gov - September 21, 2023 Category: Research Source Type: clinical trials
Left epigastric isolated tumor fed by the inferior phrenic artery diagnosed as ectopic hepatocellular carcinoma: A case report
CONCLUSION: This asymptomatic ectopic HCC case described achieved an excellent result due to early detection, radical resection, and systematic surveillance.PMID:37731571 | PMC:PMC10507550 | DOI:10.12998/wjcc.v11.i26.6231
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Hong-Bo Liu Li-Hua Zhao Yong-Jian Zhang Zhi-Feng Li Lei Li Qian-Peng Huang Source Type: research
Deuterium Magnetic Resonance Imaging Using Deuterated Water-Induced 2H-Tissue Labeling Allows Monitoring Cancer Treatment at Clinical Field Strength
CONCLUSIONS: Deuterium MRI at 1.5T proved feasibility to track 2H distribution throughout mouse tissues during D2O administration and revealed a higher 2H accumulation in the tumor xenografts. This research demonstrated a promising successful method for preliminary assessment of radiotherapy and chemotherapy of cancer.PMID:37732903 | DOI:10.1158/1078-0432.CCR-23-1635
Source: Clinical Cancer Research - September 21, 2023 Category: Cancer & Oncology Authors: Hirofumi Asano Abdelazim Elsayed Elhelaly Fuminori Hyodo Ryota Iwasaki Yoshifumi Noda Hiroki Kato Koki Ichihashi Hiroyuki Tomita Masaharu Murata Takashi Mori Masayuki Matsuo Source Type: research
Unveiling the anti-cancer mechanisms of calotropin: Insights into cell growth inhibition, cell cycle arrest, and metabolic regulation in human oral squamous carcinoma cells (HSC-3)
CONCLUSION: Overall, our findings shed an experimental evidence on how calotropin inhibits the HSC-3 oral squamous cancer cell growth, highlighting the drug's potential as a treatment for oral cancer. Further, investigation on in-vivo experiment is warranted to explore its potential mechanism of action and to develop a novel drug towards clinical trial.PMID:37731845 | PMC:PMC10507650 | DOI:10.1016/j.jobcr.2023.09.002
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Selvaraj Jayaraman Sathan Raj Natarajan Vishnu Priya Veeraraghavan Sharmila Jasmine Source Type: research
Alpinetin: anti-human gastric cancer potential and urease inhibition activity < em > in vitro < /em >
CONCLUSIONS: It seems that the anti-human gastric carcinoma effect of the investigated molecule is due to its antioxidant effects.PMID:37732032 | PMC:PMC10507754 | DOI:10.5114/aoms/138832
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Hui Zhang Qian Jiang Guojin Gong Mingzhen Li Saad H Alotaibi Source Type: research
