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Cancer: Epithelial Cancer
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Immunohistochemical Expression of Upregulated Gene 4 Protein Expression (URG4/URGCP) and Its Association with 5-Year Survival in Patients with Colon Adenocarcinoma
Conclusions: High immunohistochemical expression of URG4 correlates with poor prognosis in patients with colon adenocarcinoma.PMID:37685545 | PMC:PMC10488385 | DOI:10.3390/jcm12175477
Source: Clinical Colorectal Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Marlena Brzozowa-Zasada Adam Piecuch Marek Michalski Katarzyna St ęplewska Natalia Matysiak Marek Kucharzewski Source Type: research
Unrevealing the vital role of ncRNAs in Gastric Cancer chemoresistance
Pathol Res Pract. 2023 Aug 10;250:154761. doi: 10.1016/j.prp.2023.154761. Online ahead of print.ABSTRACTThe high incidence of gastric cancer in many nations and poor overall survival rates has remained a serious global health concern. Chemoresistance in gastric cancer is a significant issue that hinders the efficacy of available treatment options. In gastric cancer, non-coding RNAs like microRNAs, long non-coding RNAs, and circular RNAs have become effective regulators of chemoresistance. These non-coding RNAs can influence several mechanisms, including drug efflux transporters, drug metabolism, and detoxification, cancer ...
Source: Pathology, Research and Practice - September 9, 2023 Category: Pathology Authors: Aida Kazemi Masomeh Goodarzi Kosar Daneshipour Hoda Sarabadani Zahra Shahpar Bahareh Salmanian Hajiagha Hadis Kheradjoo Saman Mohammadzadehsaliani Source Type: research
SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells
Aging (Albany NY). 2023 Sep 7;15. doi: 10.18632/aging.205001. Online ahead of print.ABSTRACTDeleted in breast cancer 1 (DBC1) was initially identified from a homozygously deleted region in human chromosome 8p21. It has been well established that DBC1 plays a dual role during cancer development. Depending on the physiological context, it can promote or inhibit tumorigenesis. Whether it plays a role in lens pathogenesis remains elusive. In the present study, we demonstrated that DBC1 is highly expressed in lens epithelial cells from different vertebrates and in retina pigment epithelial cells as well. Moreover, DBC1 is SUMOy...
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Yan Wang Jing-Miao Wang Yuan Xiao Xue-Bin Hu Shu-Yu Zheng Jia-Ling Fu Lan Zhang Yu-Wen Gan Xing-Miao Liang David Wan-Cheng Li Source Type: research
Pingxiao capsule inhibits lung metastasis of triple-negative breast cancer and sensitizes breast cancer to radiotherapy
CONCLUSION: PXC could inhibit the proliferation and invasion of TNBC both and , and exerted its anti-metastatic effect by regulating cadherin turnover, Furthermore, it sensitized the TNBC cells to radiotherapy. The data supported further development of PXC as an adjuvant-therapy agent for TNBC.PMID:37679977 | PMC:PMC10465830 | DOI:10.19852/j.cnki.jtcm.20221121.003
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Tang Wenjuan H U Yu Zhu Man Dong Mingzhi Liu Tieming Sarwar Ammar Zhan Yingzhuan Zhang Yanmin Source Type: research
Active compounds of Caodoukou () inhibit the migration, invasion and metastasis of human pancreatic cancer cells by targeting phosphoinosmde-3-kinase/ protein kinase B/mammalian target of rapamycin pathway
CONCLUSIONS: ACAK can partly inhibit the activity of EMT and matrix metallopeptidases by down-regulating the downstream proteins of PI3K/Akt/mTOR signal pathway, thus inhibiting the ability of migration and invasion of pancreatic cancer.PMID:37679975 | PMC:PMC10465845 | DOI:10.19852/j.cnki.jtcm.20230802.004
Source: Journal of Traditional Chinese Medicine - September 8, 2023 Category: Complementary Medicine Authors: Yang Xiaohui Wang Jian Cheng Li Zhang Yuxi Huang Jianlin Liu Minghua Source Type: research
LncRNA CASC15 activated by TCF12 promote colorectal cancer progression via EMT
CONCLUSION: Our study identified TCF12/CASC15/EMT as a new regulatory signal axis of CRC. CASC15 may be a new molecular marker and target for CRC.PMID:37680149 | DOI:10.2174/1386207326666230901120611
Source: Combinatorial Chemistry and High Throughput Screening - September 8, 2023 Category: Chemistry Authors: Shuai Yan Ming Yuan Xichen Yang Xianting Huang Dan Wu Nanyao Wang Xia Sun Ya Qin Yanhua Fei Zhenguo Zhao Qiong Wang Source Type: research
miR-200b-mediated reversion of a spectrum of epithelial to mesenchymal transition states in recessive dystrophic epidermolysis bullosa squamous cell carcinomas
CONCLUSIONS: In summary, RDEB-SCCs exist in different EMT states and the level of miR-200b is indicative of how far an RDEB-SCC has gone down the EMT path. Moreover, reintroduction of miR-200b significantly reduced mesenchymal features.PMID:37681509 | DOI:10.1093/bjd/ljad335
Source: The British Journal of Dermatology - September 8, 2023 Category: Dermatology Authors: Julia Illmer Roland Zauner Josefina Pi ñón Hofbauer Monika Wimmer Stefanie Gruner Michael Ablinger Johannes Bischof Sonja Dorfer Stefan Hainzl Vanessa Tober Shir Bergson Ofer Sarig Liat Samuelov Christina Guttmann-Gruber Ruby Shalom-Feuerstein Eli Sprec Source Type: research
Dishevelled: An emerging therapeutic oncogene in human cancers
This study aimed to investigate the underlying molecular mechanism of DVL in cancer pathogenesis as well as to explore its importance in cancer diagnosis and prognosis as well as its role as a mediator in cancer chemotherapy.PMID:37683388 | DOI:10.1016/j.prp.2023.154793
Source: Pathology, Research and Practice - September 8, 2023 Category: Pathology Authors: Shadia Hamoud Alshahrani Nodir Rakhimov Arti Rana Hashem O Alsaab Ahmed Hjazi Mohaned Adile Munther Abosaooda Adeeb Abdulally Abdulhussien Alazbjee Ali Alsalamy Reza Mahmoudi Source Type: research
Electrolyte imbalance causes suppression of NK and T cell effector function in malignant ascites
CONCLUSION: Our data suggest a novel electrolyte-based mechanism of immunosuppression in malignant ascites of patients with peritoneal carcinomatosis. We show for the first time that the immunosuppression of NK cytotoxicity in coculture assays is correlated to patient poor survival. Therapeutic application of sodium channel inhibitors may provide new means for restoring immune cell activity in ascites or similar electrolyte imbalanced environments.PMID:37684704 | DOI:10.1186/s13046-023-02798-8
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Antonio Hrvat Mathias Schmidt Bernd Wagner Denise Zwanziger Rainer Kimmig Lothar Volbracht Sven Brandau Nina Mallmann-Gottschalk Source Type: research
Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression
CONCLUSIONS: Our findings indicated that Fn-induced NETs abundance by activating TLR4-ROS and NOD1/2 signalings in neutrophils facilitated CRC progression. The combination of circulating NETs and CEA was identified as a novel screening strategy for predicting CRC occurrence and metastasis.PMID:37684625 | DOI:10.1186/s13046-023-02817-8
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Xuehua Kong Yu Zhang Linwei Xiang Yan You Yaqian Duan Yuqing Zhao Shue Li Rui Wu Jiangbo Zhang Lan Zhou Liang Duan Source Type: research
Dishevelled: An emerging therapeutic oncogene in human cancers
This study aimed to investigate the underlying molecular mechanism of DVL in cancer pathogenesis as well as to explore its importance in cancer diagnosis and prognosis as well as its role as a mediator in cancer chemotherapy.PMID:37683388 | DOI:10.1016/j.prp.2023.154793
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Shadia Hamoud Alshahrani Nodir Rakhimov Arti Rana Hashem O Alsaab Ahmed Hjazi Mohaned Adile Munther Abosaooda Adeeb Abdulally Abdulhussien Alazbjee Ali Alsalamy Reza Mahmoudi Source Type: research
Suspension state affects the stemness of breast cancer cells by regulating the glycogen synthase kinase-3 β
This study demonstrated that suspension state could activate the Wnt/β-catenin signaling by inhibiting GSK-3β to promote the stemness of epithelial BCCs, providing a therapeutic strategy for targeted CTCs.PMID:37683322 | DOI:10.1016/j.tice.2023.102208
Source: Tissue and Cell - September 8, 2023 Category: Cytology Authors: Lini Chen Yonggang Lv Source Type: research
