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Specialty: Cancer & Oncology
Cancer: Cancer

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Total 908 results found since Jan 2013.

Pioglitazone Use and Reduced Risk of Dementia in Patients With Diabetes Mellitus With a History of Ischemic Stroke
DISCUSSION: Pioglitazone use is associated with a lower risk of dementia in DM patients, particularly in those with a history of stroke or ischemic heart disease, suggesting the possibility of applying a personalized approach when choosing pioglitazone to suppress dementia in DM patients.PMID:36792375 | DOI:10.1212/WNL.0000000000207069
Source: Cancer Control - February 15, 2023 Category: Cancer & Oncology Authors: Junghee Ha Dong Woo Choi None Kim Keun You Kim Chung Mo Nam Eosu Kim Source Type: research

Increased risk of stroke among patients with ankylosing spondylitis: A systematic review and meta-analysis
CONCLUSION: This study reveals that ankylosing spondylitis was associated with an increased risk of suffering a stroke. Management of cerebrovascular risk factors and the control of systemic inflammation should be considered in patients with ankylosing spondylitis.PMID:36906389 | DOI:10.1016/j.reumae.2023.02.002
Source: Cancer Control - March 11, 2023 Category: Cancer & Oncology Authors: Akshaya Srikanth Bhagavathula Barry L Bentley Benjamin Woolf Thusharika D Dissanayaka Jamal Rahmani Source Type: research

Impact of atrial fibrillation on the development of ischemic stroke among cancer patients classified by CHA2DS2-VASc score-a nationwide cohort study.
Conclusions: The impact of AF on risk of ischemic stroke was attenuated with advancing CHA2DS2-VASc score in patients with cancer. PMID: 29484138 [PubMed]
Source: Oncotarget - February 28, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Whole-genome sequencing of childhood cancer survivors treated with cranial radiation therapy identifies 5p15.33 locus for stroke: A report from the St. Jude Lifetime Cohort study.
CONCLUSIONS: A novel locus 5p15.33 is associated with stroke risk among childhood cancer survivors, with a possible CRT dose-specific effect. The locus is of potential clinical utility in characterizing individuals who may benefit from surveillance and intervention strategies. PMID: 31462438 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - August 27, 2019 Category: Cancer & Oncology Authors: Sapkota Y, Cheung YT, Moon W, Shelton K, Wilson CL, Wang Z, Mulrooney DA, Zhang J, Armstrong GT, Hudson MM, Robison LL, Krull KR, Yasui Y Tags: Clin Cancer Res Source Type: research

Factors leading to the risk of stroke mortality: a cross-sectional study with lung cancer patient-based large sample
To identify the risk factors for stroke mortality among lung cancer patients on the basis of the Surveillance, Epidemiology, and End Results (SEER) database. The clinical data of lung cancer patients diagnosed between 2004 and 2016 were collected in the SEER database. The stroke mortality of lung cancer patients was compared with the general population using standardized mortality ratios (SMRs). COX proportional hazard model was applied to analyze the risk factors for stroke mortality among lung cancer patients. Among 82 454 patients, 4821 (5.85%) died of stroke. The stroke mortality rate in lung cancer patients signific...
Source: European Journal of Cancer Prevention - December 16, 2021 Category: Cancer & Oncology Tags: Lung cancer Source Type: research

Novel contact-kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke
Cell Mol Life Sci. 2022 Apr 13;79(5):240. doi: 10.1007/s00018-022-04257-7.ABSTRACTIschemic stroke is a leading cause of death and disability worldwide. Increasing evidence indicates that ischemic stroke is a thromboinflammatory disease in which the contact-kinin pathway has a central role by activating pro-coagulant and pro-inflammatory processes. The blocking of distinct members of the contact-kinin pathway is a promising strategy to control ischemic stroke. Here, a plasma kallikrein and active FXII (FXIIa) inhibitor (sylvestin, contained 43 amino acids, with a molecular weight of 4790.4 Da) was first identified from fore...
Source: Cancer Control - April 13, 2022 Category: Cancer & Oncology Authors: Zhiye Zhang Chuanbin Shen Mingqian Fang Yajun Han Chengbo Long Weihui Liu Min Yang Ming Liu Dengdeng Zhang Qiqi Cao Xue Chen Yaqun Fang Qiumin Lu Zongliu Hou Yaxiong Li Zhenze Liu Xi Lei Heyu Ni Ren Lai Source Type: research

Identification of the lncRNA-miRNA ‒mRNA regulatory network for middle cerebral artery occlusion-induced ischemic stroke
Front Genet. 2023 May 9;14:1169190. doi: 10.3389/fgene.2023.1169190. eCollection 2023.ABSTRACTStroke known as a neurological disease has significant rates of disability and mortality. Middle cerebral artery occlusion (MCAO) models in rodents is crucial in stroke research to mimic human stroke. Building the mRNA and non-conding RNA network is essential for preventing MCAO-induced ischemic stroke occurrence. Herein, genome-wide mRNA, miRNA, and lncRNA expression profiles among the MCAO group at 3 h, 6 h, and 12 h after surgery and controls using high-throughput RNA sequencing. We detected differentially expressed mRNAs (DE-m...
Source: Cancer Control - May 25, 2023 Category: Cancer & Oncology Authors: Guixin Shi Dong He Hua Xiao Yu'e Liu Chuanyong Liu Fang Cao Source Type: research

Stroke with intracranial stenosis is associated with increased platelet activation in sickle cell anemia
ConclusionStroke with intracranial stenosis is associated with increased platelet activation in sickle cell anemia, and further investigation is needed on the role of anti‐platelet agents in this high‐risk population. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - March 18, 2013 Category: Cancer & Oncology Authors: Suvankar Majumdar, Samantha Webb, Erin Norcross, Venkat Mannam, Naveed Ahmad, Seth Lirette, Rathi Iyer Tags: Research Article Source Type: research

Chronic blood transfusion for primary and secondary stroke prevention in Nigerian children with sickle cell disease: A 5‐year appraisal
ConclusionHigh economic costs, unavailability of blood, need to regularly seek for blood donors, cultural beliefs, and high frequency of transfusion reactions are major challenges to a successful CBT program in Nigeria. There is a need for government subsidy on blood transfusions and improved efforts towards provision of safe and affordable blood. Pediatr Blood Cancer. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - August 19, 2013 Category: Cancer & Oncology Authors: I.A. Lagunju, B.J. Brown, O.O. Sodeinde Tags: Research Article Source Type: research

An occupational therapy intervention for residents with stroke related disabilities in UK care homes (OTCH): cluster randomised controlled trial.
CONCLUSIONS: This large phase III study provided no evidence of benefit for the provision of a routine occupational therapy service, including staff training, for care home residents living with stroke related disabilities. The established three month individualised course of occupational therapy targeting stroke related disabilities did not have an impact on measures of functional activity, mobility, mood, or health related quality of life, at all observational time points. Providing and targeting ameliorative care in this clinically complex population requires alternative strategies.Trial registration Current Controlled ...
Source: Cancer Control - February 8, 2015 Category: Cancer & Oncology Authors: Sackley CM, Walker MF, Burton CR, Watkins CL, Mant J, Roalfe AK, Wheatley K, Sheehan B, Sharp L, Stant KE, Fletcher-Smith J, Steel K, Wilde K, Irvine L, Peryer G, OTCH trial investigators Tags: BMJ Source Type: research

Diagnostic yield of echocardiography in cancer patients with ischemic stroke
Abstract The yield of echocardiography in cancer patients with acute ischemic stroke is unknown. We identified adult patients with active systemic cancer diagnosed with acute ischemic stroke at a tertiary-care cancer center from 2005 through 2009 who underwent transthoracic (TTE) or transesophageal echocardiography (TEE). Two neurologists independently reviewed all clinical data, including TTE and TEE reports, and adjudicated whether echocardiographic studies revealed a definite or possible source of stroke according to pre-defined criteria. Patients were classified as having suspected cardioembolic strokes if ima...
Source: Journal of Neuro-Oncology - April 8, 2015 Category: Cancer & Oncology Source Type: research

Comparison of Enoxaparin and Warfarin for Secondary Prevention of Cancer-Associated Stroke.
Conclusion. In cancer-associated stroke patients, treatment with enoxaparin may be more effective than treatment with warfarin for lowering the D-dimer levels. Future prospective studies are warranted to show that enoxaparin is better than warfarin for secondary prevention in cancer-associated stroke. PMID: 26064116 [PubMed]
Source: Journal of Oncology - June 15, 2015 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Stroke of luck: Scientists discover target for stroke therapy in blood-brain barrier
(Tokyo University of Science) The blood-brain barrier prevents immune cells from circulating freely in the brain, and the breakdown of its function is a major cause of post-stroke inflammation. Now, for the first time, researchers have identified how a toxic stroke byproduct, acrolein, could activate the barrier-degrading enzyme proheparanase (proHPSE). The research group has discovered that proHPSE degrades the glycocalyx within the post-stroke brain's blood vessels, providing hope for new and effective therapeutics against post-stroke inflammation.
Source: EurekAlert! - Cancer - February 22, 2021 Category: Cancer & Oncology Source Type: news

Diagnosis and Management of Stroke in Adults with Primary Brain Tumor
This article reviews the risk factors, clinical presentations, differential diagnosis, and the types of strokes frequently seen in patients with primary brain neoplasms. This includes a discussion of approaches with a review of the available literature and provides recommendations for primary and secondary prevention specific to this patient population.Recent FindingsStrokes in patients with brain tumors are often multifactorial. However, tailored approaches to stroke care are necessary to achieve optimal patient outcomes, AHA/ASA stroke guidelines provide little information on the management of stroke in cancer patients. ...
Source: Current Oncology Reports - May 11, 2022 Category: Cancer & Oncology Source Type: research

Computed Tomography Angiography Quantification of Intracranial and Extracranial Vascular Narrowing in Ischemic Stroke: Differences Between Patients With and Without Illicit Drug Use
CONCLUSIONS: By using computed tomography angiography, we found that stroke patients with history of cocaine consumption had a higher incidence of intracranial circulation narrowing compared with matched controls.PMID:36055121 | DOI:10.1097/RCT.0000000000001367
Source: Cancer Control - September 2, 2022 Category: Cancer & Oncology Authors: Eliana Bonfante-Mejia Susana Calle Luis Nunez-Rubiano Azin Aein Xu Zhang Amanda Jagolino-Cole Source Type: research