Whole-genome sequencing of childhood cancer survivors treated with cranial radiation therapy identifies 5p15.33 locus for stroke: A report from the St. Jude Lifetime Cohort study.

Whole-genome sequencing of childhood cancer survivors treated with cranial radiation therapy identifies 5p15.33 locus for stroke: A report from the St. Jude Lifetime Cohort study. Clin Cancer Res. 2019 Aug 28;: Authors: Sapkota Y, Cheung YT, Moon W, Shelton K, Wilson CL, Wang Z, Mulrooney DA, Zhang J, Armstrong GT, Hudson MM, Robison LL, Krull KR, Yasui Y Abstract PURPOSE: To identify genetic risk factors associated with risk of stroke among survivors of childhood cancer treated with cranial radiation therapy (CRT). EXPERIMENTAL DESIGN: We analyzed whole-genome sequencing (36.8-fold) data of 686 childhood cancer survivors of European ancestry [median (range): 40.4 (12.4-64.7) years old; 54% male] from the St. Jude Lifetime Cohort study treated with CRT, of whom 116 (17%) had clinically-diagnosed stroke. Association analyses (single-variant and Burden/SKAT tests) were performed, adjusting for demographic characteristics and childhood cancer treatment exposures. RESULTS: We identified a genome-wide significant association between 5p15.33 and stroke [rs112896372: hazard ratio (HR)=2.55; P=1.42 10-8], with a stronger association (HR=3.68) among survivors treated with CRT dose 25-50 Gray (Gy) and weaker associations among those treated with CRT doses 50 Gy (HRs=2.14, 2.40 and 2.28). The association was replicated in 90 CRT-exposed African survivors (HR=3.05;P=0.034). In CRT-exposed Europeans, rs112896372 significantly (P
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research

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Conclusions: Overweight and obesity was substantially prevalent among primary schoolboys with a significant rural–urban difference.
Source: Indian Journal of Public Health - Category: International Medicine & Public Health Authors: Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We are now well past a simple awareness that strokes are not just for old folks. Yes, children have strokes, too, and the incidence may exceed 1 per 100  000 or even 10 000 annually (Emerg Med Int 2011;2011:734506), more common than many childhood cancers. But, can we detect these brain attacks sooner and save brain?
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
I tried to kill my father for years. To be fair, I was following his wishes. He’d made it clear that when he no longer recognized me, when he could no longer talk, when the nurses started treating him like a toddler, he didn’t want to live any longer. My father was 58 years old when he was diagnosed with Alzheimer’s disease. He took the diagnosis with the self-deprecating humor he’d spent a lifetime cultivating, constantly cracking jokes about how he would one day turn into a zombie, a walking corpse. We had a good 10 years with him after the diagnosis. Eventually, his jokes came true. Seven years ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Alzheimer's Disease Source Type: news
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Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial. People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: HP radiotherapy, CNS injury and, to a lesser extent, chemotherapy are associated with HP disorders, which are associated with adverse health outcomes. PMID: 31373627 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
Do you believe we are born with an expiration date and that we “sign up for” a certain number of years? I heard a story today of a stellar young woman on the way to a big event who was killed in a car accident. She crossed paths with another driver who was running late for his own intended destination and he blew through a red light. The young woman was an organ donor whose generosity will save numerous lives. I know of others who were just going about a “normal” day, and they made their transition suddenly. Some are unexpectedly given a life-ending diagnosis and, as a result, experience pain and su...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Grief and Loss Health-related Personal death dying Fear Near Death Experience Source Type: blogs
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