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Drug: Acetylcysteine
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Total 244 results found since Jan 2013.
ACA-28, an anticancer compound, induces Pap1 nuclear accumulation via ROS-dependent and -independent mechanisms in fission yeast
MicroPubl Biol. 2023 Aug 31;2023. doi: 10.17912/micropub.biology.000711. eCollection 2023.ABSTRACTThe nucleocytoplasmic transport of proteins is an important mechanism to control cell fate. Pap1 is a fission yeast nucleocytoplasmic shuttling transcription factor of which localization is redox regulated. The nuclear export factor Crm1/exportin negatively regulates Pap1 by exporting it from the nucleus to the cytoplasm. Here, we describe the effect of an anti-cancer compound ACA-28, an improved derivative of 1'-acetoxychavicol acetate (ACA), on the subcellular distribution of Pap1. ACA-28 induced nuclear accumulation of Pap1...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Teruaki Takasaki Reo Obana Daiki Fujiwara Naofumi Tomimoto Golam Iftakhar Khandakar Ryosuke Satoh Reiko Sugiura Source Type: research
Chronic exposure to low-dose deltamethrin can lead to colon tissue injury through PRDX1 inactivation-induced mitochondrial oxidative stress injury and gut microbial dysbiosis
CONCLUSION: Chronic exposure to DLM, even at small doses, can cause damage to the colon tissue, which cannot be ignored. The production and use of pesticides such as DLM should be strictly regulated during agricultural production.PMID:37714033 | DOI:10.1016/j.ecoenv.2023.115475
Source: Ecotoxicology and Environmental Safety - September 15, 2023 Category: Environmental Health Authors: Rulan Ma Tuanhe Sun Xueni Wang Kaijie Ren Tianhao Min Xin Xie Dangdang Wang Kang Li Yong Zhang Kun Zhu Caijing Mo Chengxue Dang Yong Yang Hao Zhang Source Type: research
Antioxidants stimulate BACH1-dependent tumor angiogenesis
J Clin Invest. 2023 Aug 31:e169671. doi: 10.1172/JCI169671. Online ahead of print.ABSTRACTLung cancer progression relies on angiogenesis, which is a response to hypoxia typically coordinated by hypoxia-inducible transcription factors (HIFs); but growing evidence indicate that transcriptional programs beyond HIFs control tumor angiogenesis. Here we show that the redox-sensitive transcription factor BTB and CNC homology 1 (BACH1) controls the transcription of a broad range of angiogenesis genes. BACH1 is stabilized by lowering reactive oxygen species levels; consequently, angiogenesis gene expression in lung cancer cells, tu...
Source: Clinical Lung Cancer - August 31, 2023 Category: Cancer & Oncology Authors: Ting Wang Yongqiang Dong Zhiqiang Huang Guoqing Zhang Ying Zhao Haidong Yao Jianjiang Hu Elin T üksammel Huan Cai Ning Liang Xiufeng Xu Xijie Yang Sarah Schmidt Xi Qiao Susanne Schlisio Staffan Str ömblad Hong Qian Changtao Jiang Eckardt Treuter Martin Source Type: research
Cytotoxic and Apoptotic Effects of Pinostilbene and Bortezomib Combination Treatment on Human Multiple Myeloma Cells
Int J Mol Sci. 2023 Aug 9;24(16):12590. doi: 10.3390/ijms241612590.ABSTRACTMultiple myeloma (MM) is a cancer of plasma cells in the bone marrow characterized by bone lesions, hypercalcemia, anemia, and renal failure. Bortezomib (BTZ), a common treatment for MM, is a proteasome inhibitor that induces apoptosis in MM cells. However, high doses of BTZ can be very toxic, signifying a need for a synergistic drug combination to improve treatment efficacy. Resveratrol (RES), a phenolic compound found in grapes, has been shown to inhibit MM cell growth. We sought to identify a synergistic combination of BTZ with a RES derivative a...
Source: Cell Research - August 26, 2023 Category: Cytology Authors: Anna Staskiewicz Erica Wong Michael Tucker Riya Farhin Jonathan Park Rana Saade Tina Alkhazali Tu Dang Xinyu Wang Source Type: research
PI3K/mTOR inhibitor VS-5584 combined with PLK1 inhibitor exhibits synergistic anti-cancer effects on non-small cell lung cancer
Eur J Pharmacol. 2023 Aug 23:176004. doi: 10.1016/j.ejphar.2023.176004. Online ahead of print.ABSTRACTSmall molecule drugs are of significant importance in the treatment of non-small cell lung cancer (NSCLC). Here, we explored biological effects of the PI3K/mTOR inhibitor VS-5584 on NSCLC. Our findings indicated that VS-5584 administration resulted in a dose-dependent inhibition of NSCLC cell proliferation, as well as the induction of apoptosis and cycle arrest. Additionally, we observed a significant increase in intracellular reactive oxygen species (ROS) levels following VS-5584 treatment. The use of the ROS inhibitor N-...
Source: European Journal of Pharmacology - August 25, 2023 Category: Drugs & Pharmacology Authors: Senxia Zhao Yibin Li Gang Li Juanping Ye Rong Wang Xiaoting Zhang Fei Li Chang Gao Junbiao Li Jie Jiang Yanjun Mi Source Type: research
Copper nanoclusters electrochemiluminescence with tunable near-infrared emission wavelength for ultrasensitive detection of matrix metalloproteinase-2
Biosens Bioelectron. 2023 Aug 9;238:115580. doi: 10.1016/j.bios.2023.115580. Online ahead of print.ABSTRACTHerein, the methionine (Met)/N-acetyl-L-cysteine (NAC) templated copper nanoclusters (Met/NAC-Cu NCs) with tunable near-infrared region (NIR) electrochemiluminescence (ECL) emission wavelength was firstly synthesized as emitter for the ultrasensitive detection of matrix metalloproteinase-2 (MMP-2). Significantly, the NAC played the role of template and reductant of cupric to acquire Cu NCs, and the surface defect regulator Met was used to connect NAC through -S-S- bond, which could heighten the surface defect of Cu NC...
Source: Biosensors and Bioelectronics - August 18, 2023 Category: Biotechnology Authors: Xiaochun Zhu Yuxi Song Xiaofeng Wang Ying Zhou Yaqin Chai Ruo Yuan Source Type: research
Glucose Deprivation Induces Cancer Cell Death through Failure of ROS Regulation
Conclusion is clear that glucose deprivation-induced cell death is independent from ATP depletion-induced cell death.PMID:37569345 | DOI:10.3390/ijms241511969
Source: Cancer Control - August 12, 2023 Category: Cancer & Oncology Authors: Mingyu Kang Joon H Kang In A Sim Do Y Seong Suji Han Hyonchol Jang Ho Lee Sang W Kang Soo-Youl Kim Source Type: research
ROS-Sp1 axis is involved in thermochemotherapy-enhanced sensitivity of pancreatic cancer cells to gemcitabine
In conclusion, thermochemotherapy inhibited pancreatic cell viability, migration and invasion, and promoted cell apoptosis by inducing excessive ROS production, which subsequently suppressed Sp1 expression and the downstream Cox-2.PMID:37545170 | DOI:10.1002/cbin.12073
Source: Cell Biology International - August 7, 2023 Category: Cytology Authors: Pan Xi Xiaojuan Ma Fuquan Hu Liang Li Huijuan Liu Jing Zhou Wenan Wu Source Type: research
Organogold(III)-dithiocarbamate compounds and their coordination analogues as anti-tumor and anti-leishmanial metallodrugs
J Inorg Biochem. 2023 Jul 29;247:112346. doi: 10.1016/j.jinorgbio.2023.112346. Online ahead of print.ABSTRACTThe limited chemical stability of gold(III)-based compounds in physiological environment has been a challenge in drug discovery, and organometallic chemistry might provide the solution to overcome this issue. In this work, four novel cationic organogold(III)-dithiocarbamate complexes of general structure [(C^N)AuIIIDTC]PF6 (C1a - C4a, DTC = dithiocarbamate, L1 - L4, C^N = 2-anilinopyridine) are presented, and compared to their coordination gold(III)-dithiocarbamate analogues [AuIIIDTCCl2] (C1b - C4b), as potential a...
Source: Journal of Inorganic Biochemistry - August 3, 2023 Category: Biochemistry Authors: Ana Luiza de Andrade Querino Alessandra Mara de Sousa Sophie R Thomas Geraldo Magela de Lima Dalton Dittz Angela Casini Rubens Lima do Monte-Neto Heveline Silva Source Type: research
The role of the Nrf2/GSH antioxidant system in cisplatin resistance in malignant rhabdoid tumours
ConclusionsThese results suggest that targeting the Nrf2/GSH antioxidant system may present a novel therapeutic strategy to combat chemoresistance in rhabdoid tumours.
Source: Journal of Cancer Research and Clinical Oncology - July 28, 2023 Category: Cancer & Oncology Source Type: research
