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Total 13708 results found since Jan 2013.
ZNF746 promotes M2 macrophage polarisation and favours tumour progression in breast cancer via the Jagged1/Notch pathway
In conclusion, this study uncovers the role of ZNF746 in promoting M2 macrophage polarisation and suggests that ZNF746 may be a promising therapeutic target for limiting BC progression.PMID:37730102 | DOI:10.1016/j.cellsig.2023.110892
Source: Cellular Signalling - September 20, 2023 Category: Cytology Authors: Lu Liu Wen-Yue Zhao Xin-Yu Zheng Source Type: research
Downregulated BIRC5 inhibits proliferation and metastasis of melanoma through the β-catenin/HIF-1α/VEGF/MMPs pathway
CONCLUSION: Our findings revealed that ZWZ-3 could downregulate BIRC5 and inhibit melanoma proliferation and metastasis through the β-catenin/HIF-1α/VEGF/MMPs pathway. Therefore, BIRC5 represents a promising therapeutic target for the treatment of melanoma.PMID:37728702 | DOI:10.1007/s00432-023-05425-3
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Qingqing He Yijing He Changqiang Li Jianv Wang Tong Xia Xia Xiong Jixiang Xu Li Liu Source Type: research
LncRNA AP000695.2 promotes glycolysis of lung adenocarcinoma via the miR-335-3p/TEAD1 axis
This study aims to verify and explore the mechanism of AP000695.2 in glycolysis of LUAD. Overexpression plasmid and siRNA are used to construct cell models of upregulation and downregulation of AP000695.2, respectively. AP000695.2 is highly expressed in lung cancer cell lines as revealed by qPCR. Western blot analysis, FDG uptake, lactate production assay and ECAR determination results show that high expression of AP000695.2 facilitates glycolysis of LUAD cells. CCK-8, EdU staining, Transwell and wound healing assays show that high expression of AP000695.2 promotes cell growth and migration of LUAD. The relationship betwee...
Source: Acta Biochimica et Biophysica Sinica - September 19, 2023 Category: Biochemistry Authors: Shuoyan Xu Zhiming Cheng Bulin Du Yao Diao Yaming Li Xuena Li Source Type: research
Identification and characterization of colorectal-cancer-associated SNPs on the SMAD7 locus
CONCLUSION: Our findings reveal a mechanism which underlies the contribution of the fSNP rs8085824 on the SMD7 locus to CRC susceptibility.PMID:37721570 | DOI:10.1007/s00432-023-05402-w
Source: Clinical Colorectal Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Zhao Liu Yihan Zhao Hongli Song Huaxue Miao Yingying Wang Chuntian Tu Tianyun Fu Juliang Qin Bing Du Min Qian Hua Ren Source Type: research
Deciphering the immunological and prognostic features of bladder cancer through platinum-resistance-related genes analysis and identifying potential therapeutic target P4HB
ConclusionOur study demonstrates that the PRR signatures are significantly associated with clinical-pathological features, the TIME, and prognostic features. The key PRR gene, P4HB, s a biomarker for the individualized treatment of BLCA patients.
Source: Frontiers in Immunology - September 18, 2023 Category: Allergy & Immunology Source Type: research
The siRNA-mediated knockdown of SNHG4 efficiently induced pro-apoptotic signaling and suppressed metastasis in SW1116 colorectal cancer cell line
CONCLUSIONS: In conclusion, SNHG4 promotes CRC by dysregulating apoptosis and cell migration, and shows significant prognostic potential for CRC.PMID:37715875 | DOI:10.1007/s11033-023-08742-5
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Mina Khajehdehi Mohammad Khalaj-Kondori Behzad Baradaran Source Type: research
Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation
Free Radic Biol Med. 2023 Sep 13:S0891-5849(23)00627-5. doi: 10.1016/j.freeradbiomed.2023.09.009. Online ahead of print.ABSTRACTTranscription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) is the principal determinant of the cellular redox homeostasis, contributing to mitochondrial function, integrity and bioenergetics. The main negative regulator of Nrf2 is Kelch-like ECH associated protein 1 (Keap1), a substrate adaptor for Cul3/Rbx1 ubiquitin ligase, which continuously targets Nrf2 for ubiquitination and proteasomal degradation. Loss-of-function mutations in Keap1 occur frequently in lung cancer, leading ...
Source: Free Radical Biology and Medicine - September 15, 2023 Category: Biology Authors: Sharadha Dayalan Naidu Plamena R Angelova Elena V Knatko Chiara Leonardi Miroslav Novak Laureano de la Vega Ian G Ganley Andrey Y Abramov Albena T Dinkova-Kostova Source Type: research
Cancers, Vol. 15, Pages 4572: Tumor-Promoting Role of GNA14 in Colon Cancer Development
In this study, we examined the effect of GNA14 on CRC through genetic approaches in vitro and in vivo. We found that GNA14 knockdown by small interfering RNA (siRNA) inhibited the proliferation of CRC cells SW403 and HT29. Gna14 knockout mice developed normally without obvious abnormalities. However, the number of polyps in the small intestine was significantly reduced in Gna14 knockout mice compared to control mice after mating with ApcMin mice, a representative CRC mouse model. In particular, deletion of the Gna14 inhibited polyp growth, especially in the distal end of the small intestine. Histological examination showed...
Source: Cancers - September 15, 2023 Category: Cancer & Oncology Authors: Rahui Park Seungmin Lee Hyunjung Chin Anh Thai-Quynh Nguyen Daekee Lee Tags: Article Source Type: research
