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Total 58 results found since Jan 2013.

Anti-tumor activity of trimethoprim-sulfamethoxazole against melanoma skin cancer through triggering allergic reaction and promoting immunity
This study examined the potential roles of TMP-SMX in melanoma skin cancer using an immunodeficient mouse model. TMP-SMX significantly improved the survival rate and reduced the tumor weight and growth and vascular endothelial growth factor levels in melanoma skin cancer of immunodeficient mice. In the forced swimming test, TMP-SMX significantly reduced immobility time compared to the melanoma skin cancer of immunodeficient mice, indicating improved immunity. TMP-SMX significantly increased infiltration of mast cells and release of allergy-related mediators (IgE, histamine, interleukin (IL)-4, IL-5, IL-13, and IL-33) and i...
Source: International Immunopharmacology - August 3, 2023 Category: Allergy & Immunology Authors: Hee-Yun Kim Ho-Geun Kang Hyung-Min Kim Hyun-Ja Jeong Source Type: research

Antibody-mediated regulation of basophils: emerging views and clinical implications
Trends Immunol. 2023 May 3:S1471-4906(23)00059-5. doi: 10.1016/j.it.2023.04.003. Online ahead of print.ABSTRACTAn increasing number of human diseases, including allergies, infections, inflammation, and cancer, involve roles for basophils. Traditionally viewed as the rarest leukocytes that are present only in the circulation, basophils have recently emerged as important players in systemic as well as tissue-specific immune responses. Their functions are regulated by immunoglobulins (Igs), and this enables basophils to integrate diverse adaptive and innate immunity signals. IgE is well known to regulate basophil responses in...
Source: Trends in Immunology - May 5, 2023 Category: Allergy & Immunology Authors: Kang Chen Yujing Hao Mauricio Guzm án Genxia Li Andrea Cerutti Source Type: research

Inpatient Direct Oral Penicillin Challenge – A Large Prospective Cohort Study
Penicillin allergies are associated with inferior patient and antimicrobial stewardship outcomes. The long-term implementation (3.5 years) of a whole-of-hospital program to assess the safety of inpatient delabeling by direct oral challenge for low-risk penicillin allergies in hospitalized inpatients at Austin Hospital and the Peter MacCallum Cancer Centre, Australia was described here.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Kyra Chua, Sara Vogrin, Jamie Waldron, Elise Mitri, Rebecca Hall, Ana Maria Copaescu, Natasha Holmes, Jason Trubiano Source Type: research

Aryl hydrocarbon receptor: The master regulator of immune responses in allergic diseases
The aryl hydrocarbon receptor (AhR) is a widely studied ligand-activated cytosolic transcriptional factor that has been associated with the initiation and progression of various diseases, including autoimmune diseases, cancers, metabolic syndromes, and allergies. Generally, AhR responds and binds to environmental toxins/ligands, dietary ligands, and allergens to regulate toxicological, biological, cellular responses. In a canonical signaling manner, activation of AhR is responsible for the increase in cytochrome P450 enzymes which help individuals to degrade and metabolize these environmental toxins and ligands. However, c...
Source: Frontiers in Immunology - December 19, 2022 Category: Allergy & Immunology Source Type: research

Chronic Rhinosinusitis in Patients with Primary Immunodeficiency
Conclusion: Chronic rhinosinusitis is more common in patients with primary immunodeficiencies than in the normal population. For effective treatment, it is necessary to identify the factors that cause chronic rhinosinusitis. Further studies involving larger patient populations are needed to explain the mechanisms of chronic rhinosinusitis.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - December 8, 2022 Category: Allergy & Immunology Source Type: research

Allergen immunotherapy, cancer, and immune disorders
Purpose of review The purpose of this review is to provide an update on the intriguing relationships between allergies, allergen immunotherapy, cancer, and immune disorders. Allergic diseases and cancer are increasing in incidence and prevalence and a potential relationship, or not, between these diseases have been suggested for many years. Recent findings Recent findings suggest that there may be some causative effects between certain types of cancer and allergic diseases, as described in the text. Some types of cancer may be more linked to the presence of an allergic disease, than others. However, epigenetic f...
Source: Current Opinion in Allergy and Clinical Immunology - November 4, 2022 Category: Allergy & Immunology Tags: IMMUNOTHERAPY AND NEW TREATMENTS: Edited by Giovanni Passalacqua and Robert Bush Source Type: research

Different Immunoregulation Roles of Activin A Compared With TGF- β
Activin A, a critical member of the transforming growth factor-β (TGF-β) superfamily, is a pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases with immune disorder. Similar to its family member, TGF-β, activin A also transmits signals through SMAD2/SMAD3, however, they bind to distinct receptors. Recent studies have uncovered that activin A plays a pivotal role in both innate and adaptive immune systems. Here we mainly focus its effects on activation, differentiation, proliferation and function of cells which are indispensable in the immune system and meanwhile make some comparisons...
Source: Frontiers in Immunology - June 14, 2022 Category: Allergy & Immunology Source Type: research

Myeloid-Derived Suppressor Cells: The Expanding World of Helminth Modulation of the Immune System
Infection with helminths or parasitic worms are highly prevalent worldwide especially in developing regions. Helminths cause chronic infections that are associated with suppression of immune responses to unrelated pathogens, vaccines, and by-stander antigens responsible for dysregulated immune responses as occurs in diseases such as allergies. Helminths use multiple mechanisms to modulate the immune system to evade the highly polarized type 2 immune response required to expel adult worms and for immunity to reinfection. Anthelmintic drugs are efficient in reducing adult worm burdens in helminth-infected individuals, but re...
Source: Frontiers in Immunology - June 10, 2022 Category: Allergy & Immunology Source Type: research

Gut immune homeostasis: the immunomodulatory role of < em > Bacillus clausii < /em > , from basic to clinical evidence
Expert Rev Clin Immunol. 2022 Jun 8. doi: 10.1080/1744666X.2022.2085559. Online ahead of print.ABSTRACTINTRODUCTION: The gut microbiota affects the development of the gut immune system in early life. Perturbations to microbiota structure and composition during this period can have long-term consequences on the health of the individual, through its effects on the immune system. Research in the last few decades has shown that probiotic administration can reverse these effects in strain- and environment-specific ways. Bacillus clausii (B. clausii) has been in use for many decades as a safe and efficacious probiotic, but its m...
Source: Expert Review of Clinical Immunology - June 8, 2022 Category: Allergy & Immunology Authors: Rosa Mar ía Wong-Chew Jo-Anne A de Castro Lorenzo Morelli Marcos Perez Metehan Ozen Source Type: research

Semaphorin-3A: a promising therapeutic tool in allergic rhinitis
AbstractSemaphorin-3A (Sema-3A), a secreted member of the semaphorin family, is well known for playing regulatory functions at all stages of the immune response. Sema-3A transduces signals by binding to its cognate receptors, namely, class A plexins (Plxns A1 to A4) and neuropilin-1 (Nrp-1). The downstream diverse signaling pathways induced by connecting Sema-3A to its receptors were found to be involved in the pathogenesis of different immunological disorders, ranging from cancer to autoimmunity and allergies. Recent studies have demonstrated that Sema-3A expression is diminished in the murine models and patients with all...
Source: Immunologic Research - March 13, 2022 Category: Allergy & Immunology Source Type: research

Bavachin inhibits IL-4 expression by downregulating STAT6 phosphorylation and GATA-3 expression and ameliorates asthma inflammation in an animal model
This study aimed to investigate small compounds that inhibit the effect of IL-4 with the lowest cell toxicity. We found that Bavachin had the greatest ability to downregulate IL-4 in the spleen of T cells from 4get IL-4-GFP mice. To identify the underlying molecular mechanisms, we found that Bavachin could decrease the IL-4 levels by downregulating the level of Gata-3 expression and STAT6 phosphorylation. These findings reveal the potential use of Bavachin as a tool for selectively controlling diseases involving IL-4 and, more generally, STAT6-dependent responses.PMID:35134627 | DOI:10.1016/j.imbio.2022.152182
Source: Immunobiology - February 8, 2022 Category: Allergy & Immunology Authors: Zheng Liang Zecheng Luo Jian Chen Baojie Li Lin Li Chongyang Shen Source Type: research