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Therapy: Immunotherapy

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Total 743 results found since Jan 2013.

Establishment of Neutralizing Monoclonal Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 by the Screening with Exosomes Expressing the Viral Spike Protein
In this study, we propose the novel screening method for mAbs against the pathogenic infectious virus using exosome. By this method, the exosome that artificially expresses SARS-CoV-2 spike protein was purified and used as a virus-like vesicle, which could bind to the viral receptor, angiotensin-converting enzyme 2 (ACE2). As a result, seven mAbs that could bind to the spike protein were obtained and six of these clones could strongly inhibit the binding to ACE2 of both the protein corresponding to the receptor binding domain (RBD) and the exosome expressing the spike protein. Interestingly, some of these antibodies seemed...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - August 26, 2022 Category: Microbiology Authors: Chihiro Okada Etsuko Ikeda-Ishizaka Chikako Ono Yoshiharu Matsuura Hikaru Sonoda Source Type: research

Targeted therapy in Coronavirus disease 2019 (COVID-19): Implication from cell and gene therapy to immunotherapy and vaccine
Int Immunopharmacol. 2022 Aug 18;111:109161. doi: 10.1016/j.intimp.2022.109161. Online ahead of print.ABSTRACTSevere acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) is a highly pathogenic and transmissible virus. Infection caused by SARS-CoV-2 known as Coronavirus disease 2019 (COVID-19) can be severe, especially among high risk populations affected of underlying medical conditions. COVID-19 is characterized by the severe acute respiratory syndrome, a hyper inflammatory syndrome, vascular injury, microangiopathy and thrombosis. Antiviral drugs and immune modulating methods has been evaluated. So far, a particular the...
Source: International Immunopharmacology - August 23, 2022 Category: Allergy & Immunology Authors: Moein Shirzad Marjan Nourigorji Atefe Sajedi Maryam Ranjbar Faeze Rasti Zahra Sourani Mona Moradi Seyed Mostafa Mir Mohammad Yousef Memar Source Type: research

Strong T-cell activation in response to COVID-19 vaccination in multiple sclerosis patients receiving B-cell depleting therapies
Immunocompromised individuals, including multiple sclerosis (MS) patients on certain immunotherapy treatments, are considered susceptible to complications from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and specific vaccination regimens have been recommended for suitable protection. MS patients receiving anti-CD20 therapy (aCD20-MS) are considered especially vulnerable due to acquired B-cell depletion and impaired antibody production in response to virus infection and COVID-19 vaccination. Here, the humoral and cellular responses are analyzed in a group of aCD20-MS patients (n=43) compared to a ...
Source: Frontiers in Immunology - August 5, 2022 Category: Allergy & Immunology Source Type: research

Efficacy of mRNA anti-SARS-CoV-2 vaccination and dynamics of humoral immune response in patients with solid tumors: results from the institutional registry of an Italian tertiary cancer center
CONCLUSIONS: The systemic immunosuppression characterizing cancer patients did not seem to dramatically affect the humoral response to anti-SARS-CoV-2 mRNA vaccines in our population of patients with solid tumors. Further investigation is needed to dissect the interplay between immunotherapy and longitudinal dynamics of humoral response to mRNA vaccines, as well as to analyze the cellular response to mRNA vaccines in cancer patients.PMID:35923922 | PMC:PMC9340426 | DOI:10.1177/17588359221108687
Source: Adv Data - August 4, 2022 Category: Epidemiology Authors: Giovanni Fuc à Mara Lecchi Chiara Maura Ciniselli Arianna Ottini Andrea Spagnoletti Laura Mazzeo Daniele Morelli Paola Frati Martina Stroscia Elisabella Ebrahem Elisa Sottotetti Giulia Galli Maria Grazia D'Elia Riccardo Lobefaro Monika Ducceschi Lorenza Source Type: research

Treatment of Multiple Sclerosis
PURPOSE OF REVIEW Given the expansion of options for the treatment of relapsing multiple sclerosis, this review outlines the framework for developing a treatment strategy, with consideration of when to switch or discontinue therapies, and a comprehensive elaboration of the mechanisms of action, efficacy, and safety considerations for each of the therapeutic classes. RECENT FINDINGS The armamentarium of immunotherapies has grown rapidly, to encompass 19 US Food and Drug Administration (FDA)-approved immunotherapies available in 2021, which are addressed in the review. The coronavirus pandemic that began in 2020 u...
Source: CONTINUUM: Lifelong Learning in Neurology - August 1, 2022 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Fight Aging! Newsletter, August 1st 2022
In this study, we used the recently released Infinium Mouse Methylation BeadChip to compare such epigenetic modifications in C57BL/6 (B6) and DBA/2J (DBA) mice. We observed marked differences in age-associated DNA methylation in these commonly used inbred mouse strains, indicating that epigenetic clocks for one strain cannot be simply applied to other strains without further verification. Interestingly, the CpGs with highest age-correlation were still overlapping in B6 and DBA mice and included the genes Hsf4, Prima1, Aspa, and Wnt3a. Furthermore, Hsf4, Aspa, and Wnt3a revealed highly significant age-associated DNA methyla...
Source: Fight Aging! - July 31, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Aspects of Antiviral Strategies Based on Different Phototherapy Approaches: Hit by the Light
Pharmaceuticals (Basel). 2022 Jul 13;15(7):858. doi: 10.3390/ph15070858.ABSTRACTThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which caused the COVID-19 pandemic spreading around the world from late 2019, served as a ruthless reminder of the threat viruses pose to global public health. The synthesis of new antiviral drugs, as well as repurposing existing products, is a long-term ongoing process which has challenged the scientific community. One solution could be an effective, accessible, and rapidly available antiviral treatment based on phototherapy (PT). PT has been used to treat several diseases, and r...
Source: Herpes - July 27, 2022 Category: Infectious Diseases Authors: Hannah Kunstek Fanny Vreken Aminata Keita Michael R Hamblin Florence Dumar çay Mihayl Varbanov Source Type: research

Sensitivity to Vaccines, Therapeutic Antibodies, and Viral Entry Inhibitors and Advances To Counter the SARS-CoV-2 Omicron Variant
Clin Microbiol Rev. 2022 Jun 6:e0001422. doi: 10.1128/cmr.00014-22. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) keeps evolving and mutating into newer variants over time, which gain higher transmissibility, disease severity, and spread in communities at a faster rate, resulting in multiple waves of surge in Coronavirus Disease 2019 (COVID-19) cases. A highly mutated and transmissible SARS-CoV-2 Omicron variant has recently emerged, driving the extremely high peak of infections in almost all continents at an unprecedented speed and scale. The Omicron variant evades the protecti...
Source: Clinical Microbiology Reviews - July 21, 2022 Category: Microbiology Authors: Hao Zhou Michelle M øhlenberg Jigarji C Thakor Hardeep Singh Tuli Pengfei Wang Yehuda G Assaraf Kuldeep Dhama Shibo Jiang Source Type: research