Strong Coexpression of Transcription Factors PU.1 and Oct-2 in Rosai-Dorfman Disease
CONCLUSIONS: PU.1 emerged as a robust marker with crisp nuclear staining in RDD histiocytes as well as in engulfed inflammatory cells. Strong coexpression of PU.1 and Oct-2 is a useful diagnostic marker in differentiating histiocytic/dendritic cell proliferations.PMID:36239684 | DOI:10.1093/ajcp/aqac119 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - October 14, 2022 Category: Pathology Authors: Kala Gnanasekaran Kiruthiga Sheren Younes Yasodha Natkunam Source Type: research
Histiocytic Disorders of Childhood
Histiocytic disorders of childhood represent a wide spectrum of conditions that share the common histologic feature of activated or transformed “histiocytes.” Langerhans cell histiocytosis (LCH) is the most common, with an incidence of approximately 5 per million children. LCH may be difficult to distinguish from more ubiquitous causes of skin rashes, bone pain, or fever. Current chemotherapy fails to cure more than 50% of children with multifocal disease, and treatment failure is associated with increased risks of long-term sequelae. Somatic activating mitogen-activated protein kinase (MAPK) pathway–activating mutat...
Source: Pediatrics in Review - October 1, 2022 Category: Pediatrics Source Type: research
Nasal and Nasopharyngeal Rosai-Dorfman Disease
Teaching Point: Nasal and nasopharyngeal Rosai-Dorfman disease is a rare cause of nasal obstruction. Published on 2022-09-22 10:56:41 (Source: Journal of the Belgian Society of Radiology)
Source: Journal of the Belgian Society of Radiology - September 22, 2022 Category: Radiology Source Type: research
Panniculitis as a unique manifestation of Rosai-Dorfman disease
Postepy Dermatol Alergol. 2022 Aug;39(4):809-811. doi: 10.5114/ada.2022.118926. Epub 2022 Sep 1.NO ABSTRACTPMID:36090721 | PMC:PMC9454365 | DOI:10.5114/ada.2022.118926 (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - September 12, 2022 Category: Dermatology Authors: Lining Huang Hongfang Liu Ruzeng Xue Source Type: research
