Effects of LDLR Variants on Longevity via Lowered Cardiovascular Disease
This study suggests that LDLR is a promising genetic target for human longevity. Lipid-related gene targets, such as PCSK9, CETP, and APOC3, might potentially regulate human lifespan, thus offering promising prospects for developing newer nonstatin therapies.
Link: https://doi.org/10.1186/s12944-023-01983-0 (Source: Fight Aging!)
Source: Fight Aging! - January 12, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Amyloid- β Inhibits Synaptic Proteasomal Function in Alzheimer's Disease
Cells contain many proteasomes, one portion of a broad array of repair and quality control mechanisms. The proteasome is a hollow, capped cylindrical structure made of many component proteins. It admits entry only to proteins that have been decorated with the addition of a ubiquitin molecule. Once inside the proteasome's central chamber, the ubiquinated protein is disassembled into short peptides suitable for reuse in the synthesis of other proteins. This ubiquitin-proteasome system is necessary to prevent the buildup of damaged, misfolded, unfolded, or otherwise unwanted proteins.
It has been noted that proteasomal...
Source: Fight Aging! - January 11, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Hypertension Pressure Turns Vascular Smooth Muscle Cells into Foam Cells
The raised blood pressure of hypertension correlates with the development of atherosclerosis, a condition characterized by cholesterol-rich lesions that grow in blood vessel walls. Researchers have proposed mechanisms by which hypertension can cause cell dysfunction, such as by indirectly increasing circulating immune cell numbers, cells that are then drawn into the plaque and killed by it, increasing its mass. More directly, increased pressure on arterial walls causes them to become less permeable to cholesterol carried in the bloodstream, encouraging deposits to form in the inner blood vessel wall. As another potential m...
Source: Fight Aging! - January 11, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Stress Temporarily Increases Epigenetic Age
This study used DNA methylation (DNAm)-based aging clocks to measure changes in biological age in response to diverse forms of stress. The researchers began with a laboratory experiment known to produce aged physiology in young mice or restore youthful physiology to old mice by surgically joining young, 3-month-old mice with older, 20-month-old mice, which allowed them to share their blood. At the molecular level, they found that the biological age of the young mice increased when measured with most aging clocks. Once the young mice were separated from the old mice and therefore were no longer experiencing the older mouse ...
Source: Fight Aging! - January 11, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
NRF1 is Neuroprotective via Proteasomal Function
Cells maintain themselves against damage and stress via a range of maintenance processes. These include autophagy, in which proteins and structures are transported to the lysosome to be broken down by enzymes, and the ubiquitin-proteasome system, in which specific proteins are dismantled in the proteasome, among others. It is well demonstrated that upregulation of these processes improves resistance to cell stress, and can also improve long-term health, reducing risk of age-related disease and slowing progression of those conditions. Upregulation of autophagy, for example, is a feature of many interventions that modestly s...
Source: Fight Aging! - January 10, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
