A Mechanism by Which Fasting Suppresses Inflammation via the Inflammasome
Some of the benefits of fasting in later life derive from suppression of the chronic, unresolved inflammatory signaling characteristic of old age. As is usually the case in such matters, how much of the overall beneficial effect of fasting on long-term health, mortality, and life expectancy is due to this mechanism remains an open question. Similarly, while researchers here focus on one specific way in which inflammation is suppressed following fasting, via an interaction with the inflammasome, whether this specific interaction is a large or a small contribution to the whole remains to be determined, even given the interes...
Source: Fight Aging! - February 6, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
An Interview with Karl Pfleger
Karl Pfleger is one of the more prolific angel investors in the longevity industry. Naturally he is an investor in Repair Biotechnologies, the company that I co-founded with Bill Cherman and which is currently focused on a gene therapy approach to reversal of atherosclerosis. In addition to his investment and conference-going activities, Pfleger runs the very useful Aging Biotech Info resource, which has expanded from the starting point of a list of companies in the longevity industry to its present state of listing of a great many more items: conferences, books, blogs, interventions, diagnostics, and so forth. In the podc...
Source: Fight Aging! - February 5, 2024 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Further Exploration of Drainage Pathways for Cerebrospinal Fluid
Considerable progress has been made in recent years in mapping the pathways by which cerebrospinal fluid drains from the brain into the body, many of which were only recently discovered. The present consensus is that the progressive loss of this drainage with advancing age is likely important in the development of neurodegenerative conditions, allowing molecular waste such as amyloid-β to build up in the brain. Researchers here discuss a new branch of the system of cerebrospinal fluid drainage that passes behind the nose. Like the related cribriform plate pathway, this makes it off interest in the development of Alzheimer...
Source: Fight Aging! - February 5, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Greater Individual Wealth Correlates with Longer Life Expectancy
Individual wealth correlates with life expectancy, with an effect size that is in the same ballpark as those related to lifestyle choices involving exercise, diet, and consequences thereof. It remains unclear as to why wealth correlates with life expectancy. It is a part of a tangled web of correlations including intelligence, education, social status, personality traits, access to and ability to use medical services, as well as the suspicion that genetic associations with at least some of those line items (largely intelligence) may also independently affect health. Theorizing is easy, but assessing the relative contributi...
Source: Fight Aging! - February 5, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
You Can Be sure This Is Just The Beginning Of What Will Be Possible In Years To Come.
This appeared
a few days ago:
Gene therapy hailed as ‘medical magic wand’ for
hereditary swelling disorder
Single-dose
treatment transformed lives of patients with potentially deadly condition in
first human trial
Medical research
Ian Sample Science
editor @iansample
Thu 1 Feb
2024 09.00 AEDT
A
groundbreaking gene therapy has been hailed as a “medical magic wand” after the
treatment (Source: Australian Health Information Technology)
Source: Australian Health Information Technology - February 5, 2024 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Bonus Features – February 4, 2024 – 67% of healthcare pros say the top use case for AI is improving the digital front door, 78% of healthcare shift workers have trouble covering living expenses, plus 25 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News
HHS released a set of Cybersecurity Performance Goals. There are 10 Essential Goals that set “a floor of safeguards,” such as multifactor authentication and data encryption, and 10 Enhanced Goals for maturing c...
Source: EMR and HIPAA - February 4, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT American Telemedicine Association Atropos Health Avaamo Avanade Bicycle Health Bruce Cerullo Datycs Department of Health and Human Services Deputy directtrust DUOS eClinicalWorks ECRI Institute Ensemble Health Par Source Type: blogs
Fight Aging! Newsletter, February 5th 2024
In conclusion, the Immunity and Redox Clocks allow BA quantification in mice and both the ImmunolAge and RedoxAge in mice relate to lifespan.
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Senolytic CAR T Cell Therapy Improves Health in Aged Mice
https://www.fightaging.org/archives/2024/01/senolytic-car-t-cell-therapy-improves-health-in-aged-mice/
To the degree that senescent cells in a tissue exhibit distinctive surface features, one can deploy technologies such as chimeric antigen receptor T cells to selectively destroy them. T cells will destroy whatever cell binds to the chimeric antigen receptor they are equipped w...
Source: Fight Aging! - February 4, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Making a Mouse that Exhibits Human Telomere Dynamics
Telomerase acts to extend telomeres, the repeated DNA sequences at the ends of chromosomes. With every cell division, some of the telomere repeats are lost. Cells with critically short telomeres become senescent or undergo programmed cell death, having reached the Hayflick limit on replication. Some cells employ telomerase to adjust the countdown of telomere length. In humans, only stem cells use telomerase. In other species, such as mice, telomerase is much more widely expressed. There has been some interest in the research community in upregulation of telomerase as a way to improve stem cell and tissue function in old ag...
Source: Fight Aging! - February 2, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Biomarkers for Immunosenescence
The aging immune system exhibits a declining ability to destroy pathogens and dysfunctional, harmful cells. This is known as immunosenescence. There are ways to assess immune cell populations and their characteristics to measure the degree of immunosenescence, but this is comparatively costly and cannot be used on banked samples. Researchers here ask whether combinations of circulating proteins can instead be used to assess the degree of immunosenescence from a blood sample, and propose a few such biomarkers based on their analysis.
Inflammaging, the characteristics of immunosenescence, is characterized by continu...
Source: Fight Aging! - February 2, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
CISD2 Upregulation Reduces the Senescence-Associated Secretory Phenotype in Aged Skin
CISD2 expression declines with age, while upregulation of CISD2 expression has been shown in mice to improve liver function and extend life span. This strategy is expected to have broad effects on function in many tissues beyond the liver. At least some of those benefits result from an increase in the efficiency of the complex cell maintenance processes of autophagy, recycling damaged and unwanted proteins and cell structures. As is the case for other approaches to slowing aging that function via autophagy, CISD2 upregulation has the effect of reducing senescent cell burden and suppressing the harmful senescence-associated...
Source: Fight Aging! - February 2, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
DEL-1 Upregulation Promotes Bone Regeneration in Aged Mice
Bone is constantly remodeled throughout life. The extracellular matrix making up bone tissue is continually broken down by osteoclast cells and built up by osteoblast cells. In youth, these activities are balanced. With aging, however, the activity of osteoclast cells progressively outweighs the activity of osteoblast cells. The consequence is an ever greater loss of bone mineral density leading to osteoporosis. This process is also found in the bone loss characteristic of advanced periodontitis. There are many contributing factors leading to the imbalance in bone remodeling, and it isn't all that clear as to which of them...
Source: Fight Aging! - February 1, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Age-Related Changes in the Prefrontal Cortex Associate with Loss of Memory
Researchers here investigate age-related changes correlating with loss of working memory. They work with mice, but produce results that line up with observations made in other species. How neural circuits function is one distinct way of looking at the brain. Like all such approaches, it is challenging to connect it to other distinct views of the aging brain, such as proteomic or transcriptomic or cell behavior or signaling changes, or the accumulation of specific forms of age-related molecular damage. Measuring one aspect of a complex system is one thing, figuring out how many different aspects fit together into a web of i...
Source: Fight Aging! - February 1, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Removing Senescent Cells Makes Chemotherapy More Effective
Cellular senescence is protective against cancer, at least initially. When cells become senescent due to potentially cancer-inducing damage, shutting down replication and secreting pro-inflammatory signals reduces the risk of cancer and attracts the immune system to clear out other potentially cancerous cells that have not become senescent. When senescent cells linger in larger numbers, however, they begin to aid cancer by changing the environment into one that favors the growth of cancerous tissue. Thus clearing senescent cells in conjunction with traditional cancer treatments is more effective for patients than the treat...
Source: Fight Aging! - February 1, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
More on CCL17 as a Target to Reduce Inflammation in Cardiovascular Disease
Atherosclerosis is the buildup of fatty plaques in the walls of blood vessels, impeding blood flow and eventually rupturing to produce a heart attack or stroke. It is the single largest cause of human mortality. Atherosclerosis is in part an inflammatory condition, accelerated by the state of chronic inflammation that arises in later life. In this context, levels of CCL17 have been shown to rise with age, while inhibition of CCL17 has been shown to reduce chronic inflammation and slow the progression of atherosclerosis. This outcome is achieved via effects on T cell behavior; CCL17 is expressed on the surface of dendritic ...
Source: Fight Aging! - January 31, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Putting West Virginia Students on the Path to Scientific Careers
Credit: NIGMS.
Two NIGMS-funded programs are teaming up to shape the future of science and technology in West Virginia (WV). One engages high school students in science, technology, engineering, math, and medicine (STEM+M); introduces them to research; and provides direct access to college through tuition waivers. In the other program, undergraduate students are paired with a researcher at their institution for a paid internship—an important step toward a career in science.
The Health Sciences & Technology Academy
“We liken our students to rosebuds. As they grow, you see them blossom into self-confident lea...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 31, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education SEPA Training Source Type: blogs
