Non-steroidal intravitreal injection for noninfectious uveitic cystoid macular edema: Systematic review and meta-analysis
CONCLUSION: Non-steroidal intravitreal injection including bevacizumab, ranibizumab, infliximab, MTX and diclofenac appears to be an effective treatment option for noninfectious uveitic CME.PMID:37933173 | DOI:10.1177/11206721231212777 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - November 7, 2023 Category: Opthalmology Authors: Farzan Kianersi Abdolreza Rezaeian-Ramsheh Alireza Rahimi Mohammadreza Akhlaghi Alireza Dehghani Ziba Farajzadegan Mohsen Pourazizi Source Type: research
Oct biomarkers for early prognosis in diabetic macular edema treatment with ranibizumab
CONCLUSION: This study showed the value and importance of OCT parameters, such as absence of INLc, as a prognostic therapeutic response. A normalization of the macular anatomy with ranibizumab is more likely to happen in early complete responders. The association between INLc and higher glycated haemoglobin levels showed the importance of systemic metabolic control in systemic diabetic manifestations. Clinicaltrials.gov NCT04387604.PMID:37919940 | DOI:10.1177/11206721231210753 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - November 3, 2023 Category: Opthalmology Authors: Bernardete Pessoa Jo ão Leite Andr é Ferreira Jo ão Ramalhão Jo ão Poças Diana Jos é Constan ça Coelho Jo ão Figueira Angelina Meireles Jo ão Melo Beirão Source Type: research
Oct biomarkers for early prognosis in diabetic macular edema treatment with ranibizumab
CONCLUSION: This study showed the value and importance of OCT parameters, such as absence of INLc, as a prognostic therapeutic response. A normalization of the macular anatomy with ranibizumab is more likely to happen in early complete responders. The association between INLc and higher glycated haemoglobin levels showed the importance of systemic metabolic control in systemic diabetic manifestations. Clinicaltrials.gov NCT04387604.PMID:37919940 | DOI:10.1177/11206721231210753 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - November 3, 2023 Category: Opthalmology Authors: Bernardete Pessoa Jo ão Leite Andr é Ferreira Jo ão Ramalhão Jo ão Poças Diana Jos é Constan ça Coelho Jo ão Figueira Angelina Meireles Jo ão Melo Beirão Source Type: research
Oct biomarkers for early prognosis in diabetic macular edema treatment with ranibizumab
CONCLUSION: This study showed the value and importance of OCT parameters, such as absence of INLc, as a prognostic therapeutic response. A normalization of the macular anatomy with ranibizumab is more likely to happen in early complete responders. The association between INLc and higher glycated haemoglobin levels showed the importance of systemic metabolic control in systemic diabetic manifestations. Clinicaltrials.gov NCT04387604.PMID:37919940 | DOI:10.1177/11206721231210753 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - November 3, 2023 Category: Opthalmology Authors: Bernardete Pessoa Jo ão Leite Andr é Ferreira Jo ão Ramalhão Jo ão Poças Diana Jos é Constan ça Coelho Jo ão Figueira Angelina Meireles Jo ão Melo Beirão Source Type: research
Vitreous Floaters With New Intravitreal Drugs Administered by Retina Specialists
In this issue of JAMA Ophthalmology, Dessouki and colleagues describe symptomatic silicone oil microdroplets in 16 of 55 patients (29%) receiving pegcetacoplan following a single injection using a Luer lock 1-mL syringe sold by McKesson (16-PS1C). It is not unexpected that silicone oil microdroplets would be noted in some eyes following intravitreal injection because they have been reported in multiple studies for eyes receiving bevacizumab, ranibizumab, and aflibercept. The remarkable feature in this study is the high percentage of patients with symptomatic floaters after a single injection of pegcetacoplan because in pri...
Source: JAMA Ophthalmology - November 1, 2023 Category: Opthalmology Source Type: research
Comparative Efficacy, Durability and Safety of Faricimab in the Treatment of Diabetic Macular Edema: A Systematic Literature Review and Network Meta-Analysis
ConclusionFaricimab provides a new treatment option in DME with dual-pathway inhibition of VEGF and angiopoeitin-2 (Ang-2). To the authors ’ knowledge, this is the first indirect comparison of faricimab T&E in DME. The analyses indicate that faricimab T&E is associated with superior retinal drying along with numerically fewer injections compared to all other treatments given in flexible dosing regimens. It also showed superior visual acuity outcomes compared to ranibizumab and bevacizumab. (Source: Advances in Therapy)
Source: Advances in Therapy - October 27, 2023 Category: Drugs & Pharmacology Source Type: research
Effectiveness Differences of Ranibizumab and Aflibercept Action in the Treatment of Diabetic Retinopathy
CONCLUSION: Both vitreous cavity injections of LU and AF can effectively reduce the expression of vascular-related factors in the atrial fluid of DR patients, but AF has a more significant inhibitory effect on the level of inflammatory factors in patients in the short term after treatment.PMID:37820680 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - October 11, 2023 Category: Complementary Medicine Authors: Xiaoli Ma Nannan Ma Qianqian Zhang Yonghong Wang Haixia Sun Zhenyuan Yang Source Type: research
Effectiveness Differences of Ranibizumab and Aflibercept Action in the Treatment of Diabetic Retinopathy
CONCLUSION: Both vitreous cavity injections of LU and AF can effectively reduce the expression of vascular-related factors in the atrial fluid of DR patients, but AF has a more significant inhibitory effect on the level of inflammatory factors in patients in the short term after treatment.PMID:37820680 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - October 11, 2023 Category: Complementary Medicine Authors: Xiaoli Ma Nannan Ma Qianqian Zhang Yonghong Wang Haixia Sun Zhenyuan Yang Source Type: research
Effectiveness Differences of Ranibizumab and Aflibercept Action in the Treatment of Diabetic Retinopathy
CONCLUSION: Both vitreous cavity injections of LU and AF can effectively reduce the expression of vascular-related factors in the atrial fluid of DR patients, but AF has a more significant inhibitory effect on the level of inflammatory factors in patients in the short term after treatment.PMID:37820680 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - October 11, 2023 Category: Complementary Medicine Authors: Xiaoli Ma Nannan Ma Qianqian Zhang Yonghong Wang Haixia Sun Zhenyuan Yang Source Type: research
Effectiveness Differences of Ranibizumab and Aflibercept Action in the Treatment of Diabetic Retinopathy
CONCLUSION: Both vitreous cavity injections of LU and AF can effectively reduce the expression of vascular-related factors in the atrial fluid of DR patients, but AF has a more significant inhibitory effect on the level of inflammatory factors in patients in the short term after treatment.PMID:37820680 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - October 11, 2023 Category: Complementary Medicine Authors: Xiaoli Ma Nannan Ma Qianqian Zhang Yonghong Wang Haixia Sun Zhenyuan Yang Source Type: research
Effectiveness Differences of Ranibizumab and Aflibercept Action in the Treatment of Diabetic Retinopathy
CONCLUSION: Both vitreous cavity injections of LU and AF can effectively reduce the expression of vascular-related factors in the atrial fluid of DR patients, but AF has a more significant inhibitory effect on the level of inflammatory factors in patients in the short term after treatment.PMID:37820680 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - October 11, 2023 Category: Complementary Medicine Authors: Xiaoli Ma Nannan Ma Qianqian Zhang Yonghong Wang Haixia Sun Zhenyuan Yang Source Type: research
Effectiveness Differences of Ranibizumab and Aflibercept Action in the Treatment of Diabetic Retinopathy
CONCLUSION: Both vitreous cavity injections of LU and AF can effectively reduce the expression of vascular-related factors in the atrial fluid of DR patients, but AF has a more significant inhibitory effect on the level of inflammatory factors in patients in the short term after treatment.PMID:37820680 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - October 11, 2023 Category: Complementary Medicine Authors: Xiaoli Ma Nannan Ma Qianqian Zhang Yonghong Wang Haixia Sun Zhenyuan Yang Source Type: research
The efficacy and ocular safety following aflibercept, conbercept, ranibizumab, bevacizumab, and laser for retinopathy of prematurity: a systematic review and meta-analysis
ConclusionsAnti-VEGF was associated with higher retreatment and lesser incidence of myopia as compared to laser. Laser therapy was linked to more complications like retinal detachment and myopia. Ranibizumab exhibited higher recurrence and retreatment rates compared to bevacizumab, aflibercept, and conbercept. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - October 9, 2023 Category: Pediatrics Source Type: research
The efficacy and ocular safety following aflibercept, conbercept, ranibizumab, bevacizumab, and laser for retinopathy of prematurity: a systematic review and meta-analysis
Retinopathy of prematurity (ROP) is typically treated with laser photocoagulation and/or intravitreal anti-vascular endothelial growth factor (anti-VEGF). To the best of our knowledge, most systematic reviews ... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - October 9, 2023 Category: Pediatrics Authors: Jing Chen, Qingfei Hao, Jing Zhang, Yanna Du, Haoming Chen and Xiuyong Cheng Tags: Research Source Type: research
Diversity when interpreting evidence in network meta-analyses (NMAs) on similar topics: an example case of NMAs on diabetic macular oedema
ConclusionsA closer inspection of each of these trials shows how the methods, including the searches and analyses, all differ, but the findings, although presented differently and sometimes interpreted differently, were similar. (Source: Systematic Reviews)
Source: Systematic Reviews - October 7, 2023 Category: International Medicine & Public Health Source Type: research
