Vitreous Floaters With New Intravitreal Drugs Administered by Retina Specialists

In this issue of JAMA Ophthalmology, Dessouki and colleagues describe symptomatic silicone oil microdroplets in 16 of 55 patients (29%) receiving pegcetacoplan following a single injection using a Luer lock 1-mL syringe sold by McKesson (16-PS1C). It is not unexpected that silicone oil microdroplets would be noted in some eyes following intravitreal injection because they have been reported in multiple studies for eyes receiving bevacizumab, ranibizumab, and aflibercept. The remarkable feature in this study is the high percentage of patients with symptomatic floaters after a single injection of pegcetacoplan because in prior reports, silicone oil microdroplets were typically discovered after numerous injections of the anti –vascular endothelial growth factor (VEGF) drugs. This finding suggests that there may be some unique features about pegcetacoplan, the McKesson syringe, the 18-gauge 5-μm filter needles supplied by Apellis to draw up the pegcetacoplan, or the 29-gauge needle supplied by Apellis to deliver the in travitreal injection that were associated with this problem.
Source: JAMA Ophthalmology - Category: Opthalmology Source Type: research