Moving one step closer to personalized anesthesia
(Ecole Polytechnique F é d é rale de Lausanne) EPFL researchers have developed a device that can continuously measure the blood concentration of propofol - one of the main compounds used in anesthetics - in patients as they are being operated on. That will help anesthesiologists deliver more personalized doses. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 28, 2021 Category: International Medicine & Public Health Source Type: news
Escape from oblivion: How the brain reboots after deep anesthesia
(Michigan Medicine - University of Michigan) An innovative study uses the anesthetics propofol and isoflurane in humans to study the patterns of reemerging consciousness and cognitive function after anesthesia. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - May 27, 2021 Category: International Medicine & Public Health Source Type: news
Anesthesia doesn't simply turn off the brain, it changes its rhythms
(Picower Institute at MIT) Simultaneous measurement of neural rhythms and spikes across five brain areas in animals reveals how propofol induces unconsciousness. Slow rhythm signature can guide anesthesiologists to improve patient care. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 27, 2021 Category: International Medicine & Public Health Source Type: news
I.V./Volatile Anesthesia vs. I.V. or Volatile Anesthesia Alone I.V./Volatile Anesthesia vs. I.V. or Volatile Anesthesia Alone
Does the combination of propofol and volatile anesthetics have advantages in the early occurrence of postoperative nausea and vomiting or postoperative pain compared to either agent alone?BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 24, 2021 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news
Anesthesia and Long-term Oncological Outcomes Anesthesia and Long-term Oncological Outcomes
Controversy remains regarding the long-term oncological impact of propofol vs. volatile anesthetics during cancer surgery. This meta-analysis compared overall survival between the two.Anesthesia & Analgesia (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 24, 2021 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news
Dexmedetomidine and Propofol Show Similar Benefits in Adults on Mechanical Ventilation Dexmedetomidine and Propofol Show Similar Benefits in Adults on Mechanical Ventilation
A comparison of dexmedetomidine and propofol finds the drugs produce very similar outcomes when used for light sedation in adults receiving mechanical ventilation despite previous research suggesting dexmedetomidine was the superior choice.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - February 4, 2021 Category: Intensive Care Tags: Infectious Diseases News Source Type: news
Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis
RCT (n=432) found no difference for dexmedetomidine vs propofol in the number of days alive without delirium or coma (10.7 vs. 10.8 days; OR 0.96, 95%CI 0.74-1.26), ventilator-free days (23.7 vs. 24.0 days, 0.98, 0.63-1.51) or death at 90 days (38% vs. 39%; HR 1.06, 0.74-1.52). (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 4, 2021 Category: Consumer Health News Source Type: news
Dexmedetomidine, Propofol Similar in Ventilated Adults With Sepsis Dexmedetomidine, Propofol Similar in Ventilated Adults With Sepsis
No difference was found in number of days alive without acute brain dysfunction in a randomized, controlled, double-blind trial. Results support current guidelines that recommend either drug.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 2, 2021 Category: Consumer Health News Tags: Critical Care News Source Type: news
Dexmedetomidine No Better Than Propofol for Adults With Sepsis
TUESDAY, Feb. 2, 2021 -- For light sedation of mechanically ventilated adults with sepsis, outcomes do not differ significantly for those receiving dexmedetomidine or propofol, according to a study published online Feb. 2 in the New England Journal... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 2, 2021 Category: Pharmaceuticals Source Type: news
Study shows why anesthetic stops cell's walkers in their tracks
(Rice University) Researchers detail the mechanism that allows propofol, a common anesthetic, to halt the movement of kinesin proteins that deliver cargoes to the far reaches of cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 28, 2021 Category: International Medicine & Public Health Source Type: news
Sixth national summary report for NHS Benchmarking Network's Pharmacy and Medicines Optimisation project finds almost a third of hospitals report'complete outages' of medicines during COVID-19 pandemic, Pharmaceutical Journal
Data from 98 NHS trusts in England showed that some trusts experienced shortages of first-line critical care medicines, atracurium, cistracurium, and propofol. Other drugs listed as being in short supply included noradrenaline, fentanyl, lorazepam and midazolam. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 15, 2021 Category: Consumer Health News Source Type: news
Volatile vs. Total IV Anesthesia for Cancer Prognosis Volatile vs. Total IV Anesthesia for Cancer Prognosis
This study investigated whether overall and recurrence-free survival were comparable in patients who had propofol-based total intravenous versus volatile anesthesia for gastric cancer surgery.Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 15, 2020 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news
Propofol Target-controlled Infusion for Endoscopic Procedures Propofol Target-controlled Infusion for Endoscopic Procedures
This study examined the incidence of significant adverse cardiovascular and respiratory events when using propofol target-controlled infusion for sedation in gastrointestinal endoscopic procedures.BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 28, 2020 Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news
Propofol-sparing of I.V. Lidocaine in Colonoscopy Patients Propofol-sparing of I.V. Lidocaine in Colonoscopy Patients
Might the addition of intravenous lidocaine to propofol-based sedation decrease the overall propofol requirement in elderly patients during colonoscopy?BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 16, 2020 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news
Hemodynamic Effects of Propofol and Dexmedetomidine in Septic Patients Without Shock
Conclusions and Relevance: A minority of patients with sepsis who received either propofol or dexmedetomidine experienced an event. Patients with sepsis without shock receiving continuous infusions of propofol and dexmedetomidine experienced a negative hemodynamic event at similar frequencies, though the degree of hypotension seen with propofol was greater. The clinical significance of these adverse effects requires cautious use in sepsis and further investigation. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news
