Computer-assisted sedation reduces patient recovery time by almost 20 percent
(Digestive Disease Week) Use of computer-assisted propofol sedation for routine upper endoscopy and colonoscopy reduced recovery room time by almost 20 percent, according to a study released today at Digestive Disease Week® 2015. The study, conducted by researchers at Virginia Mason Medical Center, Seattle, Wash., showed the process yielded a better recovery experience than the commonly used combination of midazolam and fentanyl. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 19, 2015 Category: Cancer & Oncology Source Type: news

Dexmedetomidine Versus Remifentanil After Spinal SurgeryDexmedetomidine Versus Remifentanil After Spinal Surgery
Does remifentanil or dexmedetomidine offer better postoperative pain control when used as an adjuvant in propofol-based anesthesia during spinal surgery? BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 5, 2015 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Claris confirms patent challenge for generic Propofol in US
The company has filed a an ANDA for Propofol injection in strength of 10 mg/ml with the US Food and Drug Administration (FDA). (Source: The Economic Times)
Source: The Economic Times - December 23, 2014 Category: Consumer Health News Source Type: news

Highmark drops anesthesia ban
Health insurer Highmark Inc. has backed away from restricting the use of certain drugs used in colorectal cancer screening, opting instead to follow Medicare's lead on the issue. At issue is the use of propofol as a sedative in otherwise health patients undergoing colonoscopies and other medical procedures. Propofol, best known for the overdose death of Michael Jackson, requires that an anesthesiologist monitor administration of the drug, which is not needed when other sedatives are used before… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - December 22, 2014 Category: American Health Authors: Kris B. Mamula Source Type: news

Crayola toxicology: life-threatening causes of bluish vomiting
This article does serve to remind us of 3 important not-to-miss ingestions on the differential when a patient shows up barfing blue. Unfortunately, the authors misses an obvious mnemonic: Cerulean Blue Puke = Copper sulfate, Boric acid, Paraquat. Related posts: Green urine Propofol causes green urine An elderly woman with purple urine (Source: The Poison Review)
Source: The Poison Review - November 14, 2014 Category: Toxicology Authors: Leon Tags: Medical blue vomit boric acid copper sulfate crayola toxicology emesis paraquat Source Type: news

Propofol May Decrease Delay in Neurocognitive Recovery
Less delay versus sevoflurane general anesthesia in older patients undergoing major cancer surgery (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - November 11, 2014 Category: Cancer & Oncology Tags: Neurology, Oncology, Surgery, Anesthesiology & amp; Pain, Geriatrics, Journal, Source Type: news

SEDASYS Computer-Assisted Propofol Sedation System Rolling Out in U.S.
SEDASYS, a division of Ethicon, itself part of J&J, is releasing the SEDASYS Computer-Assisted Personalized Sedation (CAPS) System in the U.S. market. The device is intended for delivery of propofol (1% (10 mg/mL) injectable emulsion) by non-anesthesiologist clinicians when performing colonoscopy and esophagogastroduodenoscopy procedures. The technology allows administration of minimal to moderate amounts of propofol during upper and lower GI endoscopies and for monitoring of patient sedation. According to the company, only adult ASA class I and II patients are eligible to receive propofol via SEDASYS. The SEDASYS Sys...
Source: Medgadget Anesthesiology - October 14, 2014 Category: Anesthesiology Authors: Editors Tags: Anesthesiology GI Source Type: news

ISPE Set To Address Drug Shortages At Annual Meeting
Drug shortages continue to plague the pharmaceutical industry. According to a GAO report on shortages, dated February 2014, the number of shortages continues to increase in the U.S., as well as around the world. In 2007 there were 154 shortages, 114 new shortages and 40 ongoing from a prior year. In 2012, there were 456 shortages, 195 news ones and 261 ongoing. As of June 30, 2013, there were already 73 new shortages and 288 ongoing. The public health importance of these shortages cannot be overemphasized. Shortage situations have included zinc for parenteral nutrition in neonates and premature infants, doxorubicin for ov...
Source: Pharmaceutical Online News - October 6, 2014 Category: Pharmaceuticals Source Type: news

Stimulation of brain region restores consciousness to animals under general anesthesia
Stimulating the ventral tegmental area, one of two dopamine-producing regions in the brain, was able to arouse animals receiving general anesthesia with either isoflurane or propofol. The same effect did not result from stimulation of the substantia nigra. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - July 28, 2014 Category: Science Source Type: news

Stimulation of brain region restores consciousness to animals under general anesthesia
(Massachusetts General Hospital) Stimulating the ventral tegmental area, one of two dopamine-producing regions in the brain, was able to arouse animals receiving general anesthesia with either isoflurane or propofol. The same effect did not result from stimulation of the substantia nigra. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 28, 2014 Category: Global & Universal Source Type: news

Family's fury over death of teenage girl who was given the sedative which killed Michael Jackson
Amie Miller, 15, from Essex, was given Propofol - a powerful sedative blamed for the death of pop star Michael Jackson - despite it not being recommended for people under 18. (Source: the Mail online | Health)
Source: the Mail online | Health - July 25, 2014 Category: Consumer Health News Source Type: news

Good quick review of bupropion toxicity, but . . . whole bowel irrigation? Seriously??
2.5 out of 5 stars Bupropion Abuse and Overdose. Stall N et al. CMAJ 2014 Apr 28 [Epub ahead of print] No abstract available online This one-page précis is part of CMAJ‘s “Five Things To Know About _______” series. The key points include: Bupropion blocks reuptake of dopamine and norepinephrine, and also blocks the action of acetylcholine at nicotinic receptors. Burpropion is abused recreationally for its mild cocaine-like “high.” Routes of bupropion abuse include snorting, ingestion, and intravenous injection. Brupropion lowers the threshold for seizures, which may be delayed as long as ...
Source: The Poison Review - May 9, 2014 Category: Toxicology Authors: Leon Tags: Medical abuse bupropion overdose seizures Source Type: news

VIDEO: Acupuncture beats propofol for endoscopy analgesia
Read the full story on MD Consult: VIDEO: Acupuncture beats propofol for endoscopy analgesia (Source: MD Consult: News: Top Stories)
Source: MD Consult: News: Top Stories - May 9, 2014 Category: Journals (General) Source Type: news

FDA Announces Recall of Propofol Injectable Emulsion by Hospira:...
On April 18, the FDA announced the nationwide recall of seven lots of Propofol Injectable Emulsion, 1%, 200 mg/20 mL (10 mg/mL) by Hospira due to a glass defect. In light of this news, AttorneyOne, a...(PRWeb April 22, 2014)Read the full story at http://www.prweb.com/releases/2014/04/prweb11782093.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - April 22, 2014 Category: Pharmaceuticals Source Type: news

Propofol Injectable Emulsion, USP by Hospira: Recall - Visible Particulates
Injected particulate matter may result in local inflammation, phlebitis, and/or low level allergic response through mechanical disruption of tissue or immune response to the particulate. (Source: FDA MedWatch)
Source: FDA MedWatch - April 18, 2014 Category: American Health Source Type: news