Barriers and facilitators to pressure ulcer prevention behaviours by older people living in their own homes and their lay carers: a qualitative study
Conclusions There is minimal research in pressure ulcer prevention in community-dwelling older people. This study has robustly applied the theoretical domains framework to understanding barriers and facilitators to pressure ulcer prevention behaviours. Our findings will support co-design of strategies to promote preventative behaviours and are likely to be transferable to comparable healthcare systems nationally and internationally. (Source: BMJ Open)
Source: BMJ Open - March 18, 2024 Category: General Medicine Authors: Roddis, J., Dyson, J., Woodhouse, M., Devrell, A., Oakley, K., Cowdell, F. Tags: Open access, Nursing Source Type: research

Urinary bladder matrix versus dermal regeneration template for lower extremity wound coverage
ConclusionsDRT and UBM coverage had similar rates of primary wound coverage failure for lower extremity wounds.Level of evidenceDiagnostic, Level III. (Source: European Journal of Orthopaedic Surgery and Traumatology)
Source: European Journal of Orthopaedic Surgery and Traumatology - March 15, 2024 Category: Orthopaedics Source Type: research

Intraluminal negative pressure wound therapy and rectal anastomotic leak management: regular vac sponge and a nasogastric tube
Ann R Coll Surg Engl. 2024 Mar 13. doi: 10.1308/rcsann.2024.0022. Online ahead of print.NO ABSTRACTPMID:38478057 | DOI:10.1308/rcsann.2024.0022 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 13, 2024 Category: Surgery Authors: F Soliman T Zwiep Source Type: research

Intraluminal negative pressure wound therapy and rectal anastomotic leak management: regular vac sponge and a nasogastric tube
Ann R Coll Surg Engl. 2024 Mar 13. doi: 10.1308/rcsann.2024.0022. Online ahead of print.NO ABSTRACTPMID:38478057 | DOI:10.1308/rcsann.2024.0022 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 13, 2024 Category: Surgery Authors: F Soliman T Zwiep Source Type: research

Intraluminal negative pressure wound therapy and rectal anastomotic leak management: regular vac sponge and a nasogastric tube
Ann R Coll Surg Engl. 2024 Mar 13. doi: 10.1308/rcsann.2024.0022. Online ahead of print.NO ABSTRACTPMID:38478057 | DOI:10.1308/rcsann.2024.0022 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 13, 2024 Category: Surgery Authors: F Soliman T Zwiep Source Type: research

Intraluminal negative pressure wound therapy and rectal anastomotic leak management: regular vac sponge and a nasogastric tube
Ann R Coll Surg Engl. 2024 Mar 13. doi: 10.1308/rcsann.2024.0022. Online ahead of print.NO ABSTRACTPMID:38478057 | DOI:10.1308/rcsann.2024.0022 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 13, 2024 Category: Surgery Authors: F Soliman T Zwiep Source Type: research

Intraluminal negative pressure wound therapy and rectal anastomotic leak management: regular vac sponge and a nasogastric tube
Ann R Coll Surg Engl. 2024 Mar 13. doi: 10.1308/rcsann.2024.0022. Online ahead of print.NO ABSTRACTPMID:38478057 | DOI:10.1308/rcsann.2024.0022 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - March 13, 2024 Category: Surgery Authors: F Soliman T Zwiep Source Type: research

Effectiveness of combined local therapy with antibiotics and fibrin vs. vacuum-assisted wound therapy in soft tissue infections: a retrospective study
CONCLUSION: Compared to vacuum-assisted wound therapy in soft tissue infections, local fibrin-antibiotic spray shows faster clinical healing and less needed operations. Leading to shorter hospital stays and more satisfied patients. The combination of sprayed fibrin and antibiotics can be seen as a promising and effective method.PMID:38466400 | DOI:10.1007/s00068-024-02483-1 (Source: Hand Surgery)
Source: Hand Surgery - March 11, 2024 Category: Surgery Authors: S Kaiser R D Verboket J Frank I Marzi M Janko Source Type: research

Effectiveness of combined local therapy with antibiotics and fibrin vs. vacuum-assisted wound therapy in soft tissue infections: a retrospective study
ConclusionCompared to vacuum-assisted wound therapy in soft tissue infections, local fibrin-antibiotic spray shows faster clinical healing and less needed operations. Leading to shorter hospital stays and more satisfied patients. The combination of sprayed fibrin and antibiotics can be seen as a promising and effective method. (Source: European Journal of Trauma and Emergency Surgery)
Source: European Journal of Trauma and Emergency Surgery - March 11, 2024 Category: Emergency Medicine Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Molecular Medicine - March 10, 2024 Category: Molecular Biology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research

Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research