Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research
Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research
Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research
Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research
Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research
Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research
Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research
Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research
Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research
Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research
Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research
Decreased proteasome function increases oxidative stress in the early stage of pressure ulcer development
In this study, we used a mouse model of proteasomal dysfunction with an age-related phenotype to examine the role of proteasome activity in cutaneous I/R injury in vivo. Decreased proteasome function did not affect the expression of inflammatory cytokines and adhesion molecules in the I/R area in transgenic mice; however, proteasome inhibition increased oxidative stress that was not attenuated by activation of the oxidative stress response mediated by NF-E2-related factor 2 (Nrf2). In dermal fibroblasts (FCs) subjected to hypoxia-reoxygenation (H/R), proteasome inhibition induced oxidative stress and ROS production, and Nr...
Source: Experimental and Molecular Pathology - March 10, 2024 Category: Pathology Authors: Eri Murata Takuma Yoshida Utano Tomaru Saaki Yamamoto Aya Fukui-Miyazaki Akihiro Ishizu Masanori Kasahara Source Type: research
Negative pressure wound therapy with instillation and dwell time in debridement of fibrinous leg ulcers
Journal of Wound Care,Volume 33, Issue 3, Page 166-170, March 2024. (Source: Journal of Wound Care)
Source: Journal of Wound Care - March 7, 2024 Category: Nursing Authors: Alexandru Achiti Nora Zenati Christophe Seinturier Jean-Luc Cracowski Sophie Blaise Source Type: research
Artificial dermis combined with negative pressure wound therapy and platelet-rich plasma to treat traumatic wounds: a retrospective study
Journal of Wound Care,Volume 33, Issue 3, Page 189-196, March 2024. (Source: Journal of Wound Care)
Source: Journal of Wound Care - March 7, 2024 Category: Nursing Authors: Jin Zhu Li Yan Rui Hu Chunbao Yang Mingzheng Wu Ying An Shanqing Li Source Type: research
Should bone biopsy be the standard for suspected osteomyelitis in patients with pressure ulcers?
Journal of Wound Care,Volume 33, Issue 3, Page 202-206, March 2024. (Source: Journal of Wound Care)
Source: Journal of Wound Care - March 7, 2024 Category: Nursing Authors: Amy Ferris Source Type: research
