Morphine Versus Oxycodone for Cancer Pain Using a Catechol-O-methyltransferase Genotype Biomarker: A Multicenter, Randomized, Open-Label, Phase III Clinical Trial (RELIEF Study)
CONCLUSION: Using the COMT rs4680 genotype alone is not recommended for selecting between morphine and oxycodone for pain relief.PMID:36426809 | DOI:10.1093/oncolo/oyac233 (Source: The Oncologist)
Source: The Oncologist - November 25, 2022 Category: Cancer & Oncology Authors: Hiromichi Matsuoka Junji Tsurutani Yasutaka Chiba Yoshihiko Fujita Kiyohiro Sakai Takeshi Yoshida Miki Nakura Ryo Sakamoto Chihiro Makimura Yoichi Ohtake Kaoru Tanaka Hidetoshi Hayashi Masayuki Takeda Tatsuya Okuno Naoki Takegawa Koji Haratani Atsuko Koya Source Type: research
Optimizing pain management following kidney stone surgery: can we avoid narcotics?
ConclusionsNon-opioid analgesia was non-inferior to opioid analgesia in pain management after kidney stone surgery. This trial contributes to the evidence that non-opioid analgesics should be considered an effective option for pain management following non-invasive urologic procedures. (Source: World Journal of Urology)
Source: World Journal of Urology - November 13, 2022 Category: Urology & Nephrology Source Type: research
Beyond the Basics: How Should We Manage Acute Pain in Hospitalized Patients with OUD?
Case
A 23-year-old male with opioid use disorder (OUD) with intravenous use is hospitalized with a fever and several weeks of back pain. He is diagnosed with methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis of the cervical spine. He desires medication treatment for OUD (MOUD) but is afraid of inadequate pain management while hospitalized. During previous admissions, untreated pain and withdrawal led to in-hospital substance use.
Brief overview of issue
The opioid epidemic is increasing hospitalizations and inpatient mortality related to OUD.1 Patients with injection use can experience painful, lif...
Source: The Hospitalist - November 1, 2022 Category: Hospital Management Authors: Ronda Whitaker Tags: Clinical Guidelines Key Clinical Questions Pain Source Type: research
A retrospective analysis of the impact of Michigan's opioid prescribing legislation on discharge opioid prescribing at a single institution
CONCLUSIONS AND RELEVANCE: Our results indicate that the legislation implemented in Michigan to regulate opioid prescriptions was associated with a reduction in opioids prescribed to patients discharged from a community-based academic teaching hospital.PMID:36226786 | DOI:10.5055/jom.2022.0740 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - October 13, 2022 Category: Addiction Authors: Richard Sadowski Emily Hillaker Michael Chavarria Fareea Khaliq Adam Schwark Source Type: research
