Production of a p65 < sup > fl/fl < /sup > /LysMCre mouse model with dysfunctional NF- κB signaling in bone marrow-derived macrophages
Innate Immun. 2023 Nov;29(8):171-185. doi: 10.1177/17534259231205993. Epub 2023 Oct 13.ABSTRACTHere, we describe the production and characterization of a novel p65fl/fl/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-κB signaling deficiencies, a reduction in phagocytic ability, and reduced ability to produce nitrites. Despite abnormal bone marrow-derived macrophage function, p65fl/fl/LysMCre mice do not exhibit differences in naïve systemic immune profi...
Source: Innate Immunity - October 13, 2023 Category: Allergy & Immunology Authors: Ahmet K Korkaya Jeffrey Fischer Anthony Peppers Sean M Crosson Manira Rayamajhi Edward A Miao Albert S Baldwin Jennifer W Bradford Source Type: research
Production of a p65 < sup > fl/fl < /sup > /LysMCre mouse model with dysfunctional NF- κB signaling in bone marrow-derived macrophages
Innate Immun. 2023 Nov;29(8):171-185. doi: 10.1177/17534259231205993. Epub 2023 Oct 13.ABSTRACTHere, we describe the production and characterization of a novel p65fl/fl/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-κB signaling deficiencies, a reduction in phagocytic ability, and reduced ability to produce nitrites. Despite abnormal bone marrow-derived macrophage function, p65fl/fl/LysMCre mice do not exhibit differences in naïve systemic immune profi...
Source: Innate Immunity - October 13, 2023 Category: Allergy & Immunology Authors: Ahmet K Korkaya Jeffrey Fischer Anthony Peppers Sean M Crosson Manira Rayamajhi Edward A Miao Albert S Baldwin Jennifer W Bradford Source Type: research
Production of a p65 < sup > fl/fl < /sup > /LysMCre mouse model with dysfunctional NF- κB signaling in bone marrow-derived macrophages
Innate Immun. 2023 Nov;29(8):171-185. doi: 10.1177/17534259231205993. Epub 2023 Oct 13.ABSTRACTHere, we describe the production and characterization of a novel p65fl/fl/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-κB signaling deficiencies, a reduction in phagocytic ability, and reduced ability to produce nitrites. Despite abnormal bone marrow-derived macrophage function, p65fl/fl/LysMCre mice do not exhibit differences in naïve systemic immune profi...
Source: Innate Immunity - October 13, 2023 Category: Allergy & Immunology Authors: Ahmet K Korkaya Jeffrey Fischer Anthony Peppers Sean M Crosson Manira Rayamajhi Edward A Miao Albert S Baldwin Jennifer W Bradford Source Type: research
Production of a p65 < sup > fl/fl < /sup > /LysMCre mouse model with dysfunctional NF- κB signaling in bone marrow-derived macrophages
Innate Immun. 2023 Nov;29(8):171-185. doi: 10.1177/17534259231205993. Epub 2023 Oct 13.ABSTRACTHere, we describe the production and characterization of a novel p65fl/fl/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-κB signaling deficiencies, a reduction in phagocytic ability, and reduced ability to produce nitrites. Despite abnormal bone marrow-derived macrophage function, p65fl/fl/LysMCre mice do not exhibit differences in naïve systemic immune profi...
Source: Innate Immunity - October 13, 2023 Category: Allergy & Immunology Authors: Ahmet K Korkaya Jeffrey Fischer Anthony Peppers Sean M Crosson Manira Rayamajhi Edward A Miao Albert S Baldwin Jennifer W Bradford Source Type: research
Production of a p65 < sup > fl/fl < /sup > /LysMCre mouse model with dysfunctional NF- κB signaling in bone marrow-derived macrophages
Innate Immun. 2023 Nov;29(8):171-185. doi: 10.1177/17534259231205993. Epub 2023 Oct 13.ABSTRACTHere, we describe the production and characterization of a novel p65fl/fl/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-κB signaling deficiencies, a reduction in phagocytic ability, and reduced ability to produce nitrites. Despite abnormal bone marrow-derived macrophage function, p65fl/fl/LysMCre mice do not exhibit differences in naïve systemic immune profi...
Source: Innate Immunity - October 13, 2023 Category: Allergy & Immunology Authors: Ahmet K Korkaya Jeffrey Fischer Anthony Peppers Sean M Crosson Manira Rayamajhi Edward A Miao Albert S Baldwin Jennifer W Bradford Source Type: research
Production of a p65 < sup > fl/fl < /sup > /LysMCre mouse model with dysfunctional NF- κB signaling in bone marrow-derived macrophages
Innate Immun. 2023 Nov;29(8):171-185. doi: 10.1177/17534259231205993. Epub 2023 Oct 13.ABSTRACTHere, we describe the production and characterization of a novel p65fl/fl/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-κB signaling deficiencies, a reduction in phagocytic ability, and reduced ability to produce nitrites. Despite abnormal bone marrow-derived macrophage function, p65fl/fl/LysMCre mice do not exhibit differences in naïve systemic immune profi...
Source: Innate Immunity - October 13, 2023 Category: Allergy & Immunology Authors: Ahmet K Korkaya Jeffrey Fischer Anthony Peppers Sean M Crosson Manira Rayamajhi Edward A Miao Albert S Baldwin Jennifer W Bradford Source Type: research
Production of a p65 < sup > fl/fl < /sup > /LysMCre mouse model with dysfunctional NF- κB signaling in bone marrow-derived macrophages
Innate Immun. 2023 Nov;29(8):171-185. doi: 10.1177/17534259231205993. Epub 2023 Oct 13.ABSTRACTHere, we describe the production and characterization of a novel p65fl/fl/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-κB signaling deficiencies, a reduction in phagocytic ability, and reduced ability to produce nitrites. Despite abnormal bone marrow-derived macrophage function, p65fl/fl/LysMCre mice do not exhibit differences in naïve systemic immune profi...
Source: Innate Immunity - October 13, 2023 Category: Allergy & Immunology Authors: Ahmet K Korkaya Jeffrey Fischer Anthony Peppers Sean M Crosson Manira Rayamajhi Edward A Miao Albert S Baldwin Jennifer W Bradford Source Type: research
Production of a p65 < sup > fl/fl < /sup > /LysMCre mouse model with dysfunctional NF- κB signaling in bone marrow-derived macrophages
Innate Immun. 2023 Nov;29(8):171-185. doi: 10.1177/17534259231205993. Epub 2023 Oct 13.ABSTRACTHere, we describe the production and characterization of a novel p65fl/fl/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-κB signaling deficiencies, a reduction in phagocytic ability, and reduced ability to produce nitrites. Despite abnormal bone marrow-derived macrophage function, p65fl/fl/LysMCre mice do not exhibit differences in naïve systemic immune profi...
Source: Innate Immunity - October 13, 2023 Category: Allergy & Immunology Authors: Ahmet K Korkaya Jeffrey Fischer Anthony Peppers Sean M Crosson Manira Rayamajhi Edward A Miao Albert S Baldwin Jennifer W Bradford Source Type: research
Production of a p65 < sup > fl/fl < /sup > /LysMCre mouse model with dysfunctional NF- κB signaling in bone marrow-derived macrophages
Innate Immun. 2023 Nov;29(8):171-185. doi: 10.1177/17534259231205993. Epub 2023 Oct 13.ABSTRACTHere, we describe the production and characterization of a novel p65fl/fl/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-κB signaling deficiencies, a reduction in phagocytic ability, and reduced ability to produce nitrites. Despite abnormal bone marrow-derived macrophage function, p65fl/fl/LysMCre mice do not exhibit differences in naïve systemic immune profi...
Source: Innate Immunity - October 13, 2023 Category: Allergy & Immunology Authors: Ahmet K Korkaya Jeffrey Fischer Anthony Peppers Sean M Crosson Manira Rayamajhi Edward A Miao Albert S Baldwin Jennifer W Bradford Source Type: research
Production of a p65 < sup > fl/fl < /sup > /LysMCre mouse model with dysfunctional NF- κB signaling in bone marrow-derived macrophages
Innate Immun. 2023 Nov;29(8):171-185. doi: 10.1177/17534259231205993. Epub 2023 Oct 13.ABSTRACTHere, we describe the production and characterization of a novel p65fl/fl/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-κB signaling deficiencies, a reduction in phagocytic ability, and reduced ability to produce nitrites. Despite abnormal bone marrow-derived macrophage function, p65fl/fl/LysMCre mice do not exhibit differences in naïve systemic immune profi...
Source: Innate Immunity - October 13, 2023 Category: Allergy & Immunology Authors: Ahmet K Korkaya Jeffrey Fischer Anthony Peppers Sean M Crosson Manira Rayamajhi Edward A Miao Albert S Baldwin Jennifer W Bradford Source Type: research
Production of a p65 < sup > fl/fl < /sup > /LysMCre mouse model with dysfunctional NF- κB signaling in bone marrow-derived macrophages
Innate Immun. 2023 Nov;29(8):171-185. doi: 10.1177/17534259231205993. Epub 2023 Oct 13.ABSTRACTHere, we describe the production and characterization of a novel p65fl/fl/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-κB signaling deficiencies, a reduction in phagocytic ability, and reduced ability to produce nitrites. Despite abnormal bone marrow-derived macrophage function, p65fl/fl/LysMCre mice do not exhibit differences in naïve systemic immune profi...
Source: Innate Immunity - October 13, 2023 Category: Allergy & Immunology Authors: Ahmet K Korkaya Jeffrey Fischer Anthony Peppers Sean M Crosson Manira Rayamajhi Edward A Miao Albert S Baldwin Jennifer W Bradford Source Type: research
Production of a p65 < sup > fl/fl < /sup > /LysMCre mouse model with dysfunctional NF- κB signaling in bone marrow-derived macrophages
Innate Immun. 2023 Nov;29(8):171-185. doi: 10.1177/17534259231205993. Epub 2023 Oct 13.ABSTRACTHere, we describe the production and characterization of a novel p65fl/fl/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-κB signaling deficiencies, a reduction in phagocytic ability, and reduced ability to produce nitrites. Despite abnormal bone marrow-derived macrophage function, p65fl/fl/LysMCre mice do not exhibit differences in naïve systemic immune profi...
Source: Innate Immunity - October 13, 2023 Category: Allergy & Immunology Authors: Ahmet K Korkaya Jeffrey Fischer Anthony Peppers Sean M Crosson Manira Rayamajhi Edward A Miao Albert S Baldwin Jennifer W Bradford Source Type: research
Production of a p65 < sup > fl/fl < /sup > /LysMCre mouse model with dysfunctional NF- κB signaling in bone marrow-derived macrophages
Innate Immun. 2023 Nov;29(8):171-185. doi: 10.1177/17534259231205993. Epub 2023 Oct 13.ABSTRACTHere, we describe the production and characterization of a novel p65fl/fl/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-κB signaling deficiencies, a reduction in phagocytic ability, and reduced ability to produce nitrites. Despite abnormal bone marrow-derived macrophage function, p65fl/fl/LysMCre mice do not exhibit differences in naïve systemic immune profi...
Source: Innate Immunity - October 13, 2023 Category: Allergy & Immunology Authors: Ahmet K Korkaya Jeffrey Fischer Anthony Peppers Sean M Crosson Manira Rayamajhi Edward A Miao Albert S Baldwin Jennifer W Bradford Source Type: research
Production of a p65 < sup > fl/fl < /sup > /LysMCre mouse model with dysfunctional NF- κB signaling in bone marrow-derived macrophages
Innate Immun. 2023 Nov;29(8):171-185. doi: 10.1177/17534259231205993. Epub 2023 Oct 13.ABSTRACTHere, we describe the production and characterization of a novel p65fl/fl/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-κB signaling deficiencies, a reduction in phagocytic ability, and reduced ability to produce nitrites. Despite abnormal bone marrow-derived macrophage function, p65fl/fl/LysMCre mice do not exhibit differences in naïve systemic immune profi...
Source: Innate Immunity - October 13, 2023 Category: Allergy & Immunology Authors: Ahmet K Korkaya Jeffrey Fischer Anthony Peppers Sean M Crosson Manira Rayamajhi Edward A Miao Albert S Baldwin Jennifer W Bradford Source Type: research
Production of a p65 < sup > fl/fl < /sup > /LysMCre mouse model with dysfunctional NF- κB signaling in bone marrow-derived macrophages
Innate Immun. 2023 Nov;29(8):171-185. doi: 10.1177/17534259231205993. Epub 2023 Oct 13.ABSTRACTHere, we describe the production and characterization of a novel p65fl/fl/LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived macrophages that lack p65 protein reveal NF-κB signaling deficiencies, a reduction in phagocytic ability, and reduced ability to produce nitrites. Despite abnormal bone marrow-derived macrophage function, p65fl/fl/LysMCre mice do not exhibit differences in naïve systemic immune profi...
Source: Innate Immunity - October 13, 2023 Category: Allergy & Immunology Authors: Ahmet K Korkaya Jeffrey Fischer Anthony Peppers Sean M Crosson Manira Rayamajhi Edward A Miao Albert S Baldwin Jennifer W Bradford Source Type: research
