Scientists from Merck and the Walter and Eliza Hall Institute of Medical Research Discover Novel Class of Candidate Anti Malaria Agents that Block Multiple Stages of the Lifecycle of the Parasite
KENILWORTH, N.J.& MELBOURNE, Australia--(BUSINESS WIRE) March 4, 2020 --Merck (NYSE: MRK), known as MSD outside the United States and Canada, and the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, today announced... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - March 4, 2020 Category: Pharmaceuticals Source Type: clinical trials
Machine learning analysis plans for randomised controlled trials: detecting treatment effect heterogeneity with strict control of type I error
ConclusionsML analysis plans using computational notebooks (documents linked to a programming language that capture the model parameter settings, data processing choices, and evaluation criteria) along with version control can improve the robustness and transparency of RCT exploratory analyses. A data-partitioning algorithm allows researchers to apply the latest ML techniques safe in the knowledge that any declared associations are statistically significant at a user-defined level. (Source: Trials)
Source: Trials - February 9, 2020 Category: Research Source Type: clinical trials
Social group and health care provider interventions to increase the demand for malaria rapid diagnostic test among community members in Ebonyi state, Nigeria: study protocol for a cluster randomized controlled trial
This study aims to evaluate the effectiveness of social group and social group/provider interventions in increasing the demand (use and/or request) for MRDT among community members with fever or malaria-like illness in Ebonyi state, Nigeria.MethodsA three-arm, parallel, stratified cluster randomized design will be used to evaluate the effect of two interventions compared to control: control involves the usual practice of provision of MRDT services by public primary healthcare providers and patent medicine vendors; social group intervention involves the sensitization/education of social groups about MRDT; social group/provi...
Source: Trials - October 9, 2019 Category: Research Source Type: clinical trials
LLIN Evaluation in Uganda Project (LLINEUP) – Impact of long-lasting insecticidal nets with, and without, piperonyl butoxide on malaria indicators in Uganda: study protocol for a cluster-randomised trial
DiscussionPBO LLINs are a promising new tool to reduce the impact of pyrethroid resistance on malaria control. The World Health Organization has issued a preliminary endorsement of PBO LLINs, but additional epidemiological evidence of the effect of PBO LLINs is urgently needed. The results of this innovative, large-scale trial embedded within a routine national distribution campaign will make an important contribution to the malaria control policy in Uganda and throughout Africa, where pyrethroid resistance in malaria vectors has increased dramatically. This model of evaluation could be a paradigm for future assessment of ...
Source: Trials - June 2, 2019 Category: Research Source Type: clinical trials
Impact of Health Education Learning Package Against Intestinal Parasitic Infections Among Orang Asli Children
Conditions: Intestinal Parasitic Infections; Knowledge, Attitudes, Practice Intervention: Other: Health education learning package Sponsor: University of Malaya Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 29, 2019 Category: Research Source Type: clinical trials
