Cancer Precision-Prevention trial of Metformin in adults with Li Fraumeni syndrome (MILI) undergoing yearly MRI surveillance: a randomised controlled trial protocol
DiscussionAlongside a parallel MILI study being conducted by collaborators at the National Cancer Institute (NCI), MILI is the first prevention trial to be conducted in this high-risk group. The MILI study provides a unique opportunity to evaluate the efficacy of metformin as a chemopreventive alongside exploring its m echanism of anticancer action and the biological process of mutated P53-driven tumourigenesis.Trial registrationISRCTN16699730. Registered on 28 November 2022. URL:https://www.isrctn.com/ EudraCT/CTIS number 2022-000165-41. (Source: Trials)
Source: Trials - February 3, 2024 Category: Research Source Type: clinical trials
Visual Oral Examination for Early Detection of Oral Cancer in High-Risk Individuals
Conditions: Mouth Neoplasms Interventions: Diagnostic Test: Visual oral examination Sponsors: Universidade Federal do Rio de Janeiro; CNPq - National Council for Scientific and Technological Development Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 30, 2024 Category: Research Source Type: clinical trials
A Study to Learn How BAY2927088 is Taken up and Handled by the Body in Healthy Male Participants
Conditions: Advanced Non-small Cell Lung Cancer; EGFR Mutation; HER2 Mutation; Healthy Volunteers Interventions: Drug: BAY2927088 coated tablet 10 mg; Drug: [14C]-BAY2927088 solution for infusion; Drug: [14C]-BAY2927088 oral solution Sponsors: Bayer Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 24, 2024 Category: Research Source Type: clinical trials
A Phase II Study of SBRT Followed by Neoadjuvant Chemoimmunotherapy of Sindilizumab Plus Docetaxel and Cisplatin for Locoregionally Advanced Squamous Carcinoma of Oral Cavity and Oropharynx
Conditions: SBRT Interventions: Combination Product: SBRT+chemoimmunotherapy Sponsors: Sun Yat-sen University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 23, 2024 Category: Research Source Type: clinical trials
Evaluation of Prophylactic Photobiomodulation Therapy in Patients With Osteosarcoma
Conditions: Mucositis Oral Interventions: Other: Preventive photobiomodulation Therapy (PBMT) Sponsors: Instituto Nacional de Cancer, Brazil Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 22, 2024 Category: Research Source Type: clinical trials
Nasal Iodine Swab Versus Oral Antibiotic to Prevent Surgical Site Infection After Undergoing Mohs Micrographic Surgery
Conditions: Skin Cancer; Skin Cancer Face; Malignant Cutaneous Adnexal Neoplasm Interventions: Other: Povidone-Iodine Swabs; Diagnostic Test: Staphylococcus nasal swab; Drug: Antibiotic Sponsors: Mayo Clinic Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 17, 2024 Category: Research Source Type: clinical trials
The Prevalence of Oral HPV Infection and Oral Lesions in People Living With HIV
Conditions: Human Immunodeficiency Virus; Human Papilloma Virus Interventions: Diagnostic Test: Oral HPV Sample Sponsors: Vivent Health; H. Lee Moffitt Cancer Center and Research Institute Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 15, 2024 Category: Research Source Type: clinical trials
Evaluating the Addition of Elacestrant (Oral SERD) to Niraparib (PARP-inhibitor) in Patients With Advanced/Metastatic HR+/HER2- Breast Cancer
Conditions: Hormone Receptor Positive HER-2 Negative Breast Cancer; Advanced or Metastatic Breast Cancer; BRCA1 Mutation; BRCA2 Mutation; PALB2 Gene Mutation Interventions: Drug: Niraparib + Elacestrant; Drug: Niraparib Sponsors: German Breast Group; Stemline Therapeutics, Inc.; GlaxoSmithKline Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 11, 2024 Category: Research Source Type: clinical trials
A Phase Ia/Ib Open-label, Multiple Dose, Study to Determine the Recommended Dose, Evaluate PKs, PDs, Safety, and Activity of Venetoclax in Combination With Oral Decitabine/Cedazuridine (ASTX727) in Pediatric Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML)
Conditions: Acute Myeloid Leukemia Interventions: Drug: ASTX727; Drug: Venetoclax Sponsors: M.D. Anderson Cancer Center; Astex Pharmaceuticals, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 5, 2024 Category: Research Source Type: clinical trials
Oral Microbiome is Associated With the Response to Chemoradiotherapy in Initial Inoperable Patients With Esophageal Squamous Cell Cancer
Conditions: Esophageal Squamous Cell Carcinoma; Chemoradiotherapy; Initial Inoperable Interventions: Other: regular chemoradiotherapy Sponsors: Anhui Provincial Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 4, 2024 Category: Research Source Type: clinical trials
Intermittent Oral-esophageal Tube Feeding in Delayed Dysphagia After Radiotherapy for Nasopharyngeal Carcinoma
Conditions: Nasopharyngeal Carcinoma; Dysphagia Interventions: Device: Intermittent Oral-esophageal Tube Feeding; Device: nasogastric tube feeding Sponsors: The First Affiliated Hospital of Zhengzhou University; Mianyang Central Hospital; Peking University Sixth Hospital Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 3, 2024 Category: Research Source Type: clinical trials
Oral Azacitidine (CC-486) Epigenetic Priming and Maintenance for Adult Acute Myeloid Leukemia (AML) Patients
Conditions: Acute Myeloid Leukemia Interventions: Drug: oral azacitidine (CC-486) Sponsors: Yale University; Bristol-Myers Squibb; National Cancer Institute (NCI) Withdrawn (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 25, 2023 Category: Research Source Type: clinical trials
Niraparib Rechallenge After Surgery in Ovarian Cancer Patients With Oligometastatic Progression
Conditions: Ovarian Cancer; Oligometastatic Disease; Serous Ovarian Tumor Interventions: Drug: Niraparib oral tablets Sponsors: MedSIR Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 22, 2023 Category: Research Source Type: clinical trials
Assessing the Clinical Utility of Adding Pentoxifylline to Neoadjuvant Chemotherapy Protocols in Breast Cancer Patients "
Conditions: Breast Cancer Female Interventions: Drug: Pentoxifylline Oral Tablet; Drug: Placebo Sponsors: Mansoura University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 19, 2023 Category: Research Source Type: clinical trials
Pediatric Oncology Nutrition Intervention Trial
Conditions: Pediatric Cancer; Nutrition Related Cancer; Nutrition Aspect of Cancer; Muscle Loss; Malnutrition, Child Interventions: Dietary Supplement: Oral Nutrition Supplement; Dietary Supplement: Tube Feed; Drug: Cyproheptadine; Drug: Dronabinol; Other: Standard of Care Sponsors: Corey Hawes; National Center for Advancing Translational Sciences (NCATS) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 18, 2023 Category: Research Source Type: clinical trials
