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Palmitoleic Acid Ameliorates Metabolic Disorders and Inflammation by Modulating Gut Microbiota and Serum Metabolites
ConclusionThe results suggest that exogenous POA can improve metabolic disorders and inflammation in HFD-fed mice, potentially by modulating the serum metabolome and gut microbiome. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - March 22, 2024 Category: Food Science Authors: Junhui Zhang, Minjie Zhao, Huilin Yu, Qianqian Wang, Fei Shen, Haiying Cai, Fengqin Feng, Jun Tang Tags: Research Article Source Type: research

Protocol for a randomized placebo-controlled clinical trial using pure palmitoleic acid to ameliorate insulin resistance and lipogenesis in overweight and obese subjects with prediabetes
Palmitoleic acid (POA), a nonessential, monounsaturated omega-7 fatty acid (C16:1n7), is a lipid hormone secreted from adipose tissue and has beneficial effects on distant organs, such as the liver and muscle. Interestingly, POA decreases lipogenesis in toxic storage sites such as the liver and muscle, and paradoxically increases lipogenesis in safe storage sites, such as adipose tissue. Furthermore, higher POA levels in humans are correlated with better insulin sensitivity, an improved lipid profile, and a lower incidence of type-2 diabetes and cardiovascular pathologies, such as myocardial infarction. In preclinical anim...
Source: Frontiers in Endocrinology - January 19, 2024 Category: Endocrinology Source Type: research

Sea buckthorn, its bioactive constituents, and mechanism of action: potential application in female reproduction
Sea buckthorn (Hippophae rhamnoides L.) is a flowering shrub, and its berries have been utilized for decades as a raw ingredient in cuisines and herbal remedies. This evidence-based study focuses on its key bioactive constituents, and mechanism of protective effects with a focus on female reproductive processes. Parts of the plant contain phenols, carotenoids (lycopene, carotene, lutein, and zeaxanthin), flavonoids (isorhamnetin, quercetin, glycosides, and kaempferol), tocopherols, sterols, polyunsaturated fatty acids, minerals, vitamins, omega 3, 6, 9 and rare omega 7 fatty acids etc. Key polyphenolic flavonoids such as i...
Source: Frontiers in Endocrinology - November 7, 2023 Category: Endocrinology Source Type: research

Treatment of Resistant Acne Vulgaris in Adolescents Using Dietary Supplementation with Magnesium, Phosphate and Fatty Acids (Omega 6 and 7): Comparison with 13-Cis-Retinoic Acid
J Diet Suppl. 2022 Jul 25:1-11. doi: 10.1080/19390211.2022.2100550. Online ahead of print.ABSTRACTThe burden of disease associated with acne vulgaris has continued to increase over time in the world population. This continued growth suggests that there is an unmet dermatologic need for this condition worldwide. Potential sequelae of acne, such as scarring, depigmentation, and marked emotional and psychological problems (e.g., low self-esteem), can lead to significant morbidity. The purpose of this study was to investigate whether dietary supplementation with magnesium, phosphate, omega 6 (linoleic acid calcium salt - C18:2...
Source: Journal of Dietary Supplements - July 25, 2022 Category: Nutrition Authors: Ricardo de Souza Pereira Source Type: research

Allosteric modulation of cardiac myosin mechanics and kinetics by the conjugated omega-7,9 trans-fat rumenic acid
This article is protected by copyright. All rights reserved.PMID:33942907 | DOI:10.1113/JP281563 (Source: The Journal of Physiology)
Source: The Journal of Physiology - May 4, 2021 Category: Physiology Authors: Irene Pertici Manuel H Taft Johannes N Greve Pd Roman Fedorov Marco Caremani Dietmar J Manstein Source Type: research

[ASAP] Real-Time < italic toggle="yes" > In Situ < /italic > Screening of Omega-7 Phospholipids in Marine Biological Resources Using an iKnife-Rapid-Evaporative-Ionization-Mass-Spectrometry-Based Lipidomics Phenotype
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.0c05442 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - January 12, 2021 Category: Food Science Authors: Gongshuai Song, Qingcheng Wang, Mengna Zhang, Huijuan Yang, Hujun Xie, Qiaoling Zhao, Qinchao Zhu, Xiaodi Zhang, Honghai Wang, Pingya Wang, and Qing Shen Source Type: research

Molecules, Vol. 25, Pages 3660: DFT Calculations of 1H- and 13C-NMR Chemical Shifts of Geometric Isomers of Conjugated Linoleic Acid (18:2 ω-7) and Model Compounds in Solution
Gerothanassis A density functional theory (DFT) study of the 1H- and 13C-NMR chemical shifts of the geometric isomers of 18:2 &omega;-7 conjugated linoleic acid (CLA) and nine model compounds is presented, using five functionals and two basis sets. The results are compared with available experimental data from solution high resolution nuclear magnetic resonance (NMR). The experimental 1H chemical shifts exhibit highly diagnostic resonances due to the olefinic protons of the conjugated double bonds. The &ldquo;inside&rdquo; olefinic protons of the conjugated double bonds are deshielded than those...
Source: Molecules - August 10, 2020 Category: Chemistry Authors: Themistoklis Venianakis Christina Oikonomaki Michael G. Siskos Panayiotis C. Varras Alexandra Primikyri Eleni Alexandri Ioannis P. Gerothanassis Tags: Article Source Type: research

Fructose Consumption During Pregnancy Influences Milk Lipid Composition and Offspring Lipid Profiles in Guinea Pigs
Excess dietary fructose is a major public health concern (1–4). Evidence shows increased fructose intake can cause insulin resistance, hepatic de novo lipogenesis, hypertriglyceridemia, obesity and non-alcoholic fatty liver disease (NAFLD) (5–9). However, little is known about the effects of fructose during pregnancy and its influence on offspring development and predisposition to later-life disease. To determine whether moderately increased maternal fructose intake could have health consequences on offspring, we have investigated the effects of 10% w/v fructose water intake during preconception and pregnancy. Female D...
Source: Frontiers in Endocrinology - August 10, 2020 Category: Endocrinology Source Type: research

7 ‑MEGA™ 500 regulates the expression of COX‑2, MMP‑3 and type 1 procollagen in UVB‑irradiated human keratinocytes and dermal fibroblasts.
7‑MEGA™ 500 regulates the expression of COX‑2, MMP‑3 and type 1 procollagen in UVB‑irradiated human keratinocytes and dermal fibroblasts. Mol Med Rep. 2019 Dec 20;: Authors: Park YK, Yadav AK, Roshanzadeh A, Ryoo YW, Kim BH, Cha JY, Son YK, Lee NY, Jang BC Abstract AlaskOmega® Omega 7 500, also known as Omega‑7 fatty acid or 7‑MEGA™, is a highly concentrated palmitoleic acid (C16:1). Little is known about how 7‑MEGA regulates skin inflammation and wrinkle formation in cultured skin cells. The present study aimed to investigate the effects of 7‑MEGA on the expr...
Source: Molecular Medicine Reports - January 3, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research