Impact of plerixafor use in the mobilization of blood grafts for autologous hematopoietic cell transplantation
Transfusion. 2024 Feb 26. doi: 10.1111/trf.17755. Online ahead of print.ABSTRACTPlerixafor (PLER), a reversible antagonist of the CXC chemokine receptor type 4, has been in clinical use for mobilization of blood grafts for autologous hematopoietic cell transplantation (AHCT) for about 15 years. Initially PLER was investigated in placebo-controlled trials with the granulocyte colony-stimulating factor (G-CSF) filgrastim. It has also been used in combination with chemotherapy plus G-CSF in patients who had failed a previous mobilization attempt or appeared to mobilize poorly with current mobilization (preemptive use). This r...
Source: Transfusion - February 26, 2024 Category: Hematology Authors: Esa Jantunen Antti Turunen Ville Varmavuo Anu Partanen Source Type: research
Comparison of Biosimilar Filgrastim (Nivestym) Versus Originator Filgrastim (Neupogen) for Peripheral Blood Stem Cell Mobilization for Allogeneic Hematopoietic Stem Cell Transplantation
Allogeneic hematopoietic stem cell transplantation (HSCT) is an optimal and potentially curative therapy for patients with hematologic malignancies. Granulocyte colony-stimulating factor (G-CSF) is used for the mobilization of peripheral blood stem cells (PBSCs) in allogeneic donors, and an optimal CD34 cell dose plays a critical role in successful transplantation. Nivestym, a biosimilar G-CSF to the originator Filgrastim (Neupogen), is now used by multiple institutions as it has become more available; however, there is a lack of data in this regard among healthy donors for allogeneic HSCT mobilization. (Source: Biology of...
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Moazzam Shahzad, Muhammad Kashif Amin, Joe S Al-Ramahi, Muhammad Fareed Khalid, Mr. Shaun DeJarnette, Zahra Mahmoudjafari, Maggie Nelson, Forat Lutfi, Nausheen Ahmed, Haitham Abdelhakim, Rajat Bansal, Leyla Shune, Al-Ola Abdallah, Anurag K. Singh, Joseph Tags: 223 Source Type: research
From Error to Resolution: Utilizing a Multidisciplinary Team Approach to Improve Quality Outcomes
At a mid-sized Midwest transplant center, a morbidity case was presented on regarding an error of missed filgrastim dosing x 10 days post haploidentical transplant. The review found multiple missed safety steps requiring the need for several interventions. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Chris Rimkus, Rachelle Kirschner, Kacey Knapp, Shalu Lama, Janet Laquet, Amanda Liegel-Held, Stephanie McCleary, Kimberly McCormick, Rachel Mehringer, Madison O'Leary, Michael Rakey, Jimmy Thomas, Daniel Trost, Daniel Wellner Tags: 622 Source Type: research
Identifying causative medications for agranulocytosis: A case report of an older adult with cerebral infarction
We present the case of a 93-year-old man who was admitted for the treatment of cerebrovascular events. The patient was initially prescribed dual antiplatelet therapy with aspirin and clopidogrel along with lansoprazole, Hange-koboku-toh, and elobixibat. On day 36 after admission, the patient was found to have developed agranulocytosis. To improve his cerebrovascular prognosis, we first discontinued medications other than the anticoagulant medicines and initiated filgrastim. We discontinued clopidogrel 9 days after the discontinuation of the other medicines considering his low white blood cell count. One day after the di...
Source: Clinical Case Reports - January 29, 2024 Category: General Medicine Authors: Yuuri Kurokawa,
Ayako Watanabe,
Yuka Kashiwabara,
Saori Fukuda,
Shohei Nomoto,
Ayako Kuriki,
Kenji Momo Tags: CASE REPORT Source Type: research
A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Neutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colony stimulating factors (e.g., filgrastim) can be utilized to rescue th...
Source: Dermatology Online Journal - January 18, 2024 Category: Dermatology Authors: Joshi, Tejas P Source Type: research
Efficacy and safety of biosimilar Peg-filgrastim after autologous stem cell transplant in myeloma and lymphoma patients: a comparative study with biosimilar Filgrastim, Lenograstim, and originator Peg-filgrastim
In conclusion, bioPEG seems to be as effective as the originator and more effective than short -acting G-CSFs in terms of post-transplant engraftment in myeloma and lymphoma patients undergoing ASCT. Moreover, bioPEG was cost-effective when compared with the other G-CSFs. (Source: Annals of Hematology)
Source: Annals of Hematology - January 8, 2024 Category: Hematology Source Type: research
Update of triggers for detection of adverse drug events in hematologic patients
This study demonstrated the importance of an updated list of triggers for the monitoring of ADEs and improvement of the care provided.PMID:38126560 | DOI:10.1590/0102-311XPT077923 (Source: Cadernos de Saude Publica)
Source: Cadernos de Saude Publica - December 21, 2023 Category: International Medicine & Public Health Authors: Íris Pilegi Domingues Milene Rangel da Costa Source Type: research
Update of triggers for detection of adverse drug events in hematologic patients
This study demonstrated the importance of an updated list of triggers for the monitoring of ADEs and improvement of the care provided.PMID:38126560 | PMC:PMC10740396 | DOI:10.1590/0102-311XPT077923 (Source: Cadernos de Saude Publica)
Source: Cadernos de Saude Publica - December 21, 2023 Category: International Medicine & Public Health Authors: Íris Pilegi Domingues Milene Rangel da Costa Source Type: research
Update of triggers for detection of adverse drug events in hematologic patients
This study demonstrated the importance of an updated list of triggers for the monitoring of ADEs and improvement of the care provided.PMID:38126560 | PMC:PMC10740396 | DOI:10.1590/0102-311XPT077923 (Source: Cadernos de Saude Publica)
Source: Cadernos de Saude Publica - December 21, 2023 Category: International Medicine & Public Health Authors: Íris Pilegi Domingues Milene Rangel da Costa Source Type: research
Update of triggers for detection of adverse drug events in hematologic patients
This study demonstrated the importance of an updated list of triggers for the monitoring of ADEs and improvement of the care provided.PMID:38126560 | PMC:PMC10740396 | DOI:10.1590/0102-311XPT077923 (Source: Cadernos de Saude Publica)
Source: Cadernos de Saude Publica - December 21, 2023 Category: International Medicine & Public Health Authors: Íris Pilegi Domingues Milene Rangel da Costa Source Type: research
Update of triggers for detection of adverse drug events in hematologic patients
This study demonstrated the importance of an updated list of triggers for the monitoring of ADEs and improvement of the care provided.PMID:38126560 | PMC:PMC10740396 | DOI:10.1590/0102-311XPT077923 (Source: Cadernos de Saude Publica)
Source: Cadernos de Saude Publica - December 21, 2023 Category: International Medicine & Public Health Authors: Íris Pilegi Domingues Milene Rangel da Costa Source Type: research
Update of triggers for detection of adverse drug events in hematologic patients
This study demonstrated the importance of an updated list of triggers for the monitoring of ADEs and improvement of the care provided.PMID:38126560 | PMC:PMC10740396 | DOI:10.1590/0102-311XPT077923 (Source: Cadernos de Saude Publica)
Source: Cadernos de Saude Publica - December 21, 2023 Category: International Medicine & Public Health Authors: Íris Pilegi Domingues Milene Rangel da Costa Source Type: research
Update of triggers for detection of adverse drug events in hematologic patients
This study demonstrated the importance of an updated list of triggers for the monitoring of ADEs and improvement of the care provided.PMID:38126560 | PMC:PMC10740396 | DOI:10.1590/0102-311XPT077923 (Source: Cadernos de Saude Publica)
Source: Cadernos de Saude Publica - December 21, 2023 Category: International Medicine & Public Health Authors: Íris Pilegi Domingues Milene Rangel da Costa Source Type: research
Update of triggers for detection of adverse drug events in hematologic patients
This study demonstrated the importance of an updated list of triggers for the monitoring of ADEs and improvement of the care provided.PMID:38126560 | PMC:PMC10740396 | DOI:10.1590/0102-311XPT077923 (Source: Cadernos de Saude Publica)
Source: Cadernos de Saude Publica - December 21, 2023 Category: International Medicine & Public Health Authors: Íris Pilegi Domingues Milene Rangel da Costa Source Type: research
Update of triggers for detection of adverse drug events in hematologic patients
This study demonstrated the importance of an updated list of triggers for the monitoring of ADEs and improvement of the care provided.PMID:38126560 | PMC:PMC10740396 | DOI:10.1590/0102-311XPT077923 (Source: Cadernos de Saude Publica)
Source: Cadernos de Saude Publica - December 21, 2023 Category: International Medicine & Public Health Authors: Íris Pilegi Domingues Milene Rangel da Costa Source Type: research
