Settling the Issue: Does Neupogen Increase the Risk of Rejection After Heart Transplant?
Purpose: Immunosuppression after heart transplantation (HTx) includes the use of calcineurin inhibitor, antiproliferative agent and corticosteroids. Antiproliferative agents are known to decrease white blood cell (WBC) counts after HTx. Though these agents may be held, leukopenia is commonly seen. If the WBC count is be less than 2.0 x 103/L, use of granulocyte colony-stimulating factor (G-CSF known as Neupogen) may be considered. Stimulating the bone marrow with Neupogen does increase the WBC but there is concern that this stimulation may cause rejection. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Patel, M. Kittleson, E. Kransdorf, N. Bhatnagar, A. Kanungo, M. Lee, M. Hamilton, A. Hage, D. Megna, L. Czer, J. Kobashigawa Source Type: research
Aortitis after switching short-acting granulocyte colony-stimulating factors in a lymphoma patient with HLA-B52
We report the case of a 55-year-old man with refractory diffuse large B-cell lymphoma, who developed G-CSF-associated aortitis. The aortitis was triggered by filgrastim and recurred after treatment with lenograstim. The patient possessed human leukocyte antigen B52, which has been implicated in Takayasu arteritis. In addition, a drug-induced lymphocyte stimulation test for lenograstim performed upon detection of recurrent G-CSF-associated aortitis produced a positive result. Our case suggests that switching from one short-acting G-CSF to another does not prevent recurrence of G-CSF-associated aortitis. Although the etiolog...
Source: International Journal of Hematology - March 24, 2024 Category: Hematology Authors: Misato Tane Hideki Kosako Hiroki Hosoi Yoshiaki Furuya Yoshikazu Hori Yusuke Yamashita Shogo Murata Toshiki Mushino Takashi Sonoki Source Type: research
Aortitis after switching short-acting granulocyte colony-stimulating factors in a lymphoma patient with HLA-B52
We report the case of a 55-year-old man with refractory diffuse large B-cell lymphoma, who developed G-CSF-associated aortitis. The aortitis was triggered by filgrastim and recurred after treatment with lenograstim. The patient possessed human leukocyte antigen B52, which has been implicated in Takayasu arteritis. In addition, a drug-induced lymphocyte stimulation test for lenograstim performed upon detection of recurrent G-CSF-associated aortitis produced a positive result. Our case suggests that switching from one short-acting G-CSF to another does not prevent recurrence of G-CSF-associated aortitis. Although the etiolog...
Source: International Journal of Hematology - March 24, 2024 Category: Hematology Authors: Misato Tane Hideki Kosako Hiroki Hosoi Yoshiaki Furuya Yoshikazu Hori Yusuke Yamashita Shogo Murata Toshiki Mushino Takashi Sonoki Source Type: research
A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662999.ABSTRACTNeutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colo...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tejas P Joshi Yelena Dokic Gordana Verstovsek Theodore Rosen Source Type: research
A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662999.ABSTRACTNeutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colo...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tejas P Joshi Yelena Dokic Gordana Verstovsek Theodore Rosen Source Type: research
A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662999.ABSTRACTNeutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colo...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tejas P Joshi Yelena Dokic Gordana Verstovsek Theodore Rosen Source Type: research
A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662999.ABSTRACTNeutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colo...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tejas P Joshi Yelena Dokic Gordana Verstovsek Theodore Rosen Source Type: research
A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662999.ABSTRACTNeutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colo...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tejas P Joshi Yelena Dokic Gordana Verstovsek Theodore Rosen Source Type: research
A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662999.ABSTRACTNeutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colo...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tejas P Joshi Yelena Dokic Gordana Verstovsek Theodore Rosen Source Type: research
A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662999.ABSTRACTNeutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colo...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tejas P Joshi Yelena Dokic Gordana Verstovsek Theodore Rosen Source Type: research
A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662999.ABSTRACTNeutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colo...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tejas P Joshi Yelena Dokic Gordana Verstovsek Theodore Rosen Source Type: research
A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662999.ABSTRACTNeutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colo...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tejas P Joshi Yelena Dokic Gordana Verstovsek Theodore Rosen Source Type: research
A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662999.ABSTRACTNeutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colo...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tejas P Joshi Yelena Dokic Gordana Verstovsek Theodore Rosen Source Type: research
A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662999.ABSTRACTNeutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colo...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tejas P Joshi Yelena Dokic Gordana Verstovsek Theodore Rosen Source Type: research
A case of filgrastim-induced neutrophilic dermatosis of the dorsal hands in a patient with Felty Syndrome
Dermatol Online J. 2023 Dec 15;29(6). doi: 10.5070/D329662999.ABSTRACTNeutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colo...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Tejas P Joshi Yelena Dokic Gordana Verstovsek Theodore Rosen Source Type: research
