Neupogen Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Is PEGylation of Drugs Associated with Hypersensitivity Reactions? An Analysis of the Italian National Spontaneous Adverse Drug Reaction Reporting System
ConclusionsThe findings of this analysis of the Italian spontaneous adverse drug reaction database suggest a potential involvement for PEGylation in triggering drug-related hypersensitivity reactions, especially clinically relevant reactions. However, when comparing both PEGylated and non-PEGylated drugs under study to all other drugs no disproportionate reporting of hypersensitivity reactions was observed, probably due to a masking effect owing to the presence in the same database of other medicinal products increasing the threshold required to highlight a safety signal when the entire database is used as a reference. (Source: Drug Safety)
Source: Drug Safety - February 15, 2023 Category: Drugs & Pharmacology Source Type: research

Comparative Safety Profiles of Oncology Biosimilars: A Systematic Review and Network Meta-analysis
ConclusionThe meta-analysis and NMA for all four biosimilars showed that the safety and immunogenicity profiles of biosimilar products in oncology are generally comparable with that of the original biologics at the TEAE level. However, additional evidence needs to be collected since several TEAEs of specific biosimilars were out of the equivalent range. The results of this study provide comparative safety information and a better understanding of oncology biosimilars for healthcare providers to prescribe them to patients. (Source: BioDrugs)
Source: BioDrugs - February 2, 2023 Category: Drugs & Pharmacology Source Type: research

Effectiveness of Innovator Pegfilgrastim (Neulastim ®), Generic Pegfilgrastim (Linkix®) and Filgrastim for Engraftment after Auto-HSCT in an Outpatient Setting
(Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2023 Category: Hematology Authors: Fernando De la Garza Salazar, Mariana Jazmin Moedano Mata, Ver ónica del Carmen Estrada Rosales, David Gomez Almaguer, Cesar H. Gutiérrez Aguirre, José Carlos Jaime Perez, Olga Cantú Rodríguez, Consuelo Macias Guerra, Andres Gomez De Leon, Perla Roc� Tags: POSTER SESSION: ACUTE REGIMEN-RELATED TOXICITY AND SUPPORTIVE CARE Source Type: research

Pegfilgrastim on febrile neutropenia in pediatric and adolescent cancer patients: a systematic review and meta-analysis
CONCLUSION: There was no difference between pegfilgrastim and filgrastim for the rate of FN. The use of pegfilgrastim was still associated with rates of FN, grade 4 FN, severe neutropenia, and treatment delays due to FN in pediatric cancer patients.PMID:36719297 | DOI:10.1080/16078454.2023.2172292 (Source: Hematology)
Source: Hematology - January 31, 2023 Category: Hematology Authors: Xia Zhu Weiling Zhang Yi Zhang Yizhuo Wang Huimin Hu Jing Li Yan Zhou Tao Han Dongsheng Huang Source Type: research

Monitoring of Autoantibodies Following Autologous Hematopoietic Stem Cell Transplantation in 6 Children with Recently Diagnosed Type 1 Diabetes Mellitus
CONCLUSIONS Autologous hematopoietic stem cell transplantation without immunoablation was safe and effective in significantly decreasing the production and effect of autoantibodies against ICA, GAD, and IA2, as well as decreasing blood sugar levels and HbA1c.PMID:36659834 | DOI:10.12659/MSM.938979 (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 20, 2023 Category: Research Authors: Alejandro D Mesples Desiree C T Cox Harriet D Lundy Sheena Antonio-Collie Charles W Diggiss Jonathan R T Lakey Source Type: research

Proliferative glomerulonephritis with monoclonal IgG deposits triggered by Filgrastim in a patient with multiple myeloma
J Nephrol. 2023 Jan 18. doi: 10.1007/s40620-022-01555-y. Online ahead of print.NO ABSTRACTPMID:36652170 | DOI:10.1007/s40620-022-01555-y (Source: Journal of Nephrology)
Source: Journal of Nephrology - January 18, 2023 Category: Urology & Nephrology Authors: Juan M Villegas-Gamas Sof ía E Márquez-Macedo Brenda Jim énez-Franco Jorge I Fonseca-Correa Juan M Mej ía-Vilet Source Type: research

Impact of relative dose intensity of trabectedin with pegfilgrastim support: a single-centre retrospective study
J Chemother. 2023 Jan 12:1-8. doi: 10.1080/1120009X.2022.2164116. Online ahead of print.ABSTRACTRelative dose intensity (RDI) has been associated with improved survival in patients with advanced solid tumours. However, there is no evidence regarding RDI in patients under long-term treatment with trabectedin for adult advanced soft tissue sarcoma (STS). Pegfilgrastim use was associated with chemotherapy dose intensity maintenance in patients with various cancers. We retrospectively evaluated the RDI in patients with STS receiving trabectedin. The patients were grouped based on whether trabectedin administration was supporte...
Source: Journal of Chemotherapy - January 12, 2023 Category: Cancer & Oncology Authors: Yoshimasa Saito Tatsunori Shimoi Shintaro Iwata Aiko Maejima Kentaro Abe Ryoko Udagawa Kan Yonemori Tetsuya Furukawa Fumihiko Wakao Source Type: research