122 Psoriasis modeling with an advanced immunocompetent in vitro system
An advanced disease in vitro model to recapitulate psoriasis feature has been developed by using an human multi-compartment reconstructed full-thickness skin (3C System) co-cultured in the dermal compartment with THP-1 cells. The psoriatic phenotype was induced by exposure to a mixture of Th-1 cytokines (IL-17, IL-22 and TNF α) in the culture media during 48h. Two anti-psoriatic reference products have been evaluated: Product A containing mometasone furoate and Product B containing calcipotriol and betamethasone compared to negative (NC) and positive (PC) controls). (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - November 1, 2023 Category: Dermatology Authors: M. Meloni, F. Rescigno, M. Le Roux, C. Baudoin, C. Pellevoisin Source Type: research
Novel corticosteroid formulations in the treatment of eosinophilic esophagitis: what is the evidence?
CONCLUSIONS: Current evidence supports long-term treatment with novel corticosteroid formulations, challenging the established treatment paradigm of EoE. BOT appears to be the most effective steroid therapy, although head-to-head comparative trials between STCs are needed.PMID:37814560 | DOI:10.51821/86.3.11757 (Source: Acta Gastro-Enterologica Belgica)
Source: Acta Gastro-Enterologica Belgica - October 10, 2023 Category: Gastroenterology Authors: S Walgraeve T Vanuytsel Source Type: research
