Nocturnal hypertension : Something Important is being cooked in the hypertensive world !
Some physics: Why is blood under pressure?
In perfect vascular climatic conditions, the human circulatory system is comparable to a smooth flowing river irrigating 100 trillion cells, traversing many kilometers of the capillary network, to the far away tissue bed. One major difference in the river analogy is, that in human biology, the entire blood has to return back to the heart in about 30 seconds. (The fact that the venous system does this in style with near-zero pressure head is the greatest wonder in circulatory physiology)
The force per unit area, that drives the blood is the blood pressure. It is expressed...
Source: Dr.S.Venkatesan MD - June 12, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Hypertension systemic hypertension acc aha esc hypertension guidelines dippers non dippers melatonin for nocturnal hypertension night time bp reverse dipper Source Type: blogs
Fight Aging! Newsletter, June 6th 2022
This study examines evidence suggesting that mitochondrial dysfunction plays a significant early impact on AD pathology.
Although mitochondrial dysfunction is a typical indication of Alzheimer's disease, it is unclear whether the cellular systems that maintain mitochondrial integrity malfunction, aggravating mitochondrial pathology. Different levels of vigilance and preventive methods are used to reduce mitochondrial damage and efficiently destroy faulty mitochondria to maintain the mitochondrial equilibrium. The form and function of mitochondria are regulated by mitochondrial fusion and fission. In contrast, mitoch...
Source: Fight Aging! - June 5, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Enhancing Mitochondrial Function in the Context of Age-Related Macular Degeneration
Retinal degeneration is a prevalent issue in later life, and age-related macular degeneration is the poster child for this class of conditions. It is irreversible at present, setting aside a few technology demonstrations of gene therapies and cell therapies, but researchers are seeking cost-effective ways to at least slow it down. Mitochondria are the power plants of the cell, responsible for packaging energy store molecules to power cellular processes. They also generate potentially harmful free radicals while doing so. Mitochondrial function declines with age, less packaging and more free radicals, and this contributes t...
Source: Fight Aging! - May 30, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 20th 2021
In conclusion, the low dose, prolonged angiotensin II exposure is associated with the induction of senescence in kidneys and the promotion of an inflammatory microenvironment through both secreted factors and immune cells. Endothelial cells appear to be a major cell type impacted. The elimination of senescent cells in the INK-ATTAC transgenic model prevents these effects of angiotensin II and reveals a novel pathophysiologic mechanism amenable to targeting by senolytic drugs in development.
CYTOR Upregulation as a Path to Improved Muscle Function in Later Life
https://www.fightaging.org/archives/2021/12/cytor-...
Source: Fight Aging! - December 19, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
It is Entirely Reasonable to Consider That There Is No Limit to Human Life Span
The author of this commentary is entirely too enthusiastic about mTOR inhibitors as a tool to slow the aging process, but here he is largely focused on a different question. He argues (a) the sensible point that limits to aging and longevity are entirely determined by medical technology, and (b) the more debatable point that old people do not receive sufficient application of present forms of medical technology, and this is life-limiting. How much of the observed compression of morbidity of recent decades, meaning that people are living more healthy, functional years without an increase in overall life expectancy, is the r...
Source: Fight Aging! - December 14, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 15th 2021
This article will review the relationship between diabetes mellitus and AD as it relates to tau pathology. More understanding of the link between diabetes mellitus and AD could change the approach researchers and clinicians take toward both diseases, potentially leading to new treatments and preventative strategies in the future.
Signaling from White Fat Tissue Contributes to Age-Related Hair Follicle Dysfunction
https://www.fightaging.org/archives/2021/11/signaling-from-white-fat-tissue-contributes-to-age-related-hair-follicle-dysfunction/
Changes in fat tissue behavior in the skin take place with age,...
Source: Fight Aging! - November 14, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Literature on Prevention of Cellular Senescence in Stem Cells
In today's open access paper, the authors report on a literature search for efforts to reduce cellular senescence in stem cell populations. The majority of the work they list, involving the assessment of pharmacological agents that can influence the onset of cellular senescence, has taken place in cell cultures, an environment that has very little relevance to what happens in stem cell niches in a living organism. Stem cells in a petri dish undergo very different rates of replication, have different stresses and signals, are not subject to interactions with supporting cells of the niche, and so forth.
Thus I'd be in...
Source: Fight Aging! - November 9, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 12th 2021
In conclusion, our study demonstrated that elevated cumulative SBP or DBP was independently associated with increased risk of CVD in the Chinese population. Among participants with 15-year cumulative BP levels higher than the median, that is, 1970.8/1239.9 mmHg-year for cumulative SBP/DBP, which was equivalent to maintaining SBP/DBP level higher than 131/83 mmHg in 15 years, the CVD risk would increase significantly irrespective of whether or not the BP measurements at one examination was high. Our findings emphasize the importance of cumulative BP level in identifying individuals with high risk of CVD in the future.
...
Source: Fight Aging! - July 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Tryptophan and Age-Related Changes in the Gut Microbiome
Researchers here suggest that reduced tryptophan intake can change the balance of populations in the gut microbiome to favor inflammatory microbes. Diet in late life is often deficient, with consequences that can approach outright malnutrition. It seems unlikely that this is a major issue earlier in life, however, and the gut microbiome exhibits harmful shifts in composition as early as the mid-30s. The influence of changes in the gut microbiome on health may be in a similar range to those of exercise, so it is a topic of growing interest in the research community. Ways to preserve or reset the gut microbiome have been dem...
Source: Fight Aging! - July 7, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 31st 2021
In conclusion, iMSC-sEVs could rejuvenate the senescence of NPCs and attenuate the development of IVDD.
Cell Signaling via Exosomes in the Development of Vascular Calcification
https://www.fightaging.org/archives/2021/05/cell-signaling-via-exosomes-in-the-development-of-vascular-calcification/
Vascular calcification is a feature of aging, a process in which cells in the blood vessel wall take on inappropriate identities and activities that are more appropriate to bone tissue. Evidence of recent years implicates chronic inflammation and the presence of senescent cells in this process. Senescent cells cau...
Source: Fight Aging! - May 30, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cell Signaling via Exosomes in the Development of Vascular Calcification
Vascular calcification is a feature of aging, a process in which cells in the blood vessel wall take on inappropriate identities and activities that are more appropriate to bone tissue. Evidence of recent years implicates chronic inflammation and the presence of senescent cells in this process. Senescent cells cause harm via their signaling, a good fraction of which is carried via forms of extracellular vesicle, such as exosomes. Here, researchers review what is known of the signaling that may be involved in changing the behavior of cells towards calcification processes. Whether or not it is necessary to understand all of ...
Source: Fight Aging! - May 26, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Normal Toddler Behavior vs ADHD
An official diagnosis of ADHD can be hard to pinpoint as its symptoms can often be indicative of other conditions, but it is especially hard to diagnose in children under the age of four, as most children naturally experience about a year of extreme energy that generally encompasses their third birthday. This realization may be, in turn, both comforting and exhausting as parents learn that their toddler is likely just exhibiting the rampant energy normal for their age group.
What is ADHD?
Children with an official diagnosis of ADHD consistently present symptoms of inattentiveness, over-activity, impulsivity, or some combin...
Source: Conversations with Dr Greene - May 18, 2021 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog ADHD Toddler ADHD Source Type: blogs
Doxepin, a Little Known Super Drug in My Personal Black Bag of Tricks
By HANS DUVEFELT
A while back I was able to completely stop my mastocytosis patient’s chronic hives, which the allergist had been unable to control.
I did it with a drug that has been on the market since 1969 and is taken once a day at a cost of 40 cents per capsule at Walmart pharmacies.
Hives are usually treated with antihistamines like diphenhydramine (Benadryl). My super drug has a 24 hour duration of effect and is about 800 times more potent than diphenhydramine, which has to be taken every fours hours around the clock.
Histamine is involved in allergic reactions, but it also plays a role ...
Source: The Health Care Blog - April 9, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Primary Care Hans Duvefelt Source Type: blogs
Do vitamin D, zinc, and other supplements help prevent COVID-19 or hasten healing?
In this study, people whose symptoms did not require hospital admission were randomly assigned to receive
only vitamin C, 8,000 mg/day (the recommended daily amount is 75 mg/day for women and 90 mg/day for men)
only zinc, 50 mg/day (the recommended daily amount is 8 mg/day for women, 11 mg/day for men)
both supplements at the doses above
neither supplement.
The researchers found that people receiving the supplements, whether individually or combined, had no improvement in symptoms or a faster recovery when compared with otherwise similar patients receiving neither supplement.
Proponents of melatonin for COVID-19 have enc...
Source: Harvard Health Blog - April 5, 2021 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Vitamins and supplements Source Type: blogs
7 Tips To Help With Insomnia Naturally And Quickly
A healthy lifestyle revolves around the daily habits and dietary aid you include in your life. It is one of the significant factors behind long-term wellness and disease-free life. If you wish to enhance your lifestyle, you must be willing to make the essential changes. From the excessive intake of sugar-laden snacks to your meals’ timing, everything affects your health in the long run. Also, it contributes to lack of sleep and constant sleep disturbances now and then. But, you can get rid of the signs of insomnia with minimal lifestyle changes and natural aids.
Here are the top ways in which you can achieve a refresh...
Source: PickTheBrain | Motivation and Self Improvement - April 2, 2021 Category: Consumer Health News Authors: Rebecca R Tags: depression featured health and fitness self-improvement health benefits of sleep insomnia pickthebrain Source Type: blogs
