pH-dependent conformational change within the Lassa virus transmembrane domain elicits efficient membrane fusion
Biochim Biophys Acta Biomembr. 2023 Sep 19:184233. doi: 10.1016/j.bbamem.2023.184233. Online ahead of print.ABSTRACTLassa virus (LASV) is the most prevalent member of the arenavirus family and the causative agent of Lassa fever, a viral hemorrhagic fever. Although there are annual outbreaks in West Africa, and recently isolated cases worldwide, there are no current therapeutics or vaccines, which poses LASV as a significant global public health threat. One of the key steps in LASV infection is the delivery of its genetic material by fusing its viral membrane with the host cell membrane. This process is facilitated by signi...
Source: Biochimica et Biophysica Acta - September 21, 2023 Category: Biochemistry Authors: Patrick M Keating Nicholas P Schifano Xinrui Wei Matthew Y Kong Jinwoo Lee Source Type: research
pH-dependent conformational change within the Lassa virus transmembrane domain elicits efficient membrane fusion
Biochim Biophys Acta Biomembr. 2023 Sep 19:184233. doi: 10.1016/j.bbamem.2023.184233. Online ahead of print.ABSTRACTLassa virus (LASV) is the most prevalent member of the arenavirus family and the causative agent of Lassa fever, a viral hemorrhagic fever. Although there are annual outbreaks in West Africa, and recently isolated cases worldwide, there are no current therapeutics or vaccines, which poses LASV as a significant global public health threat. One of the key steps in LASV infection is the delivery of its genetic material by fusing its viral membrane with the host cell membrane. This process is facilitated by signi...
Source: Biochimica et Biophysica Acta - September 21, 2023 Category: Biochemistry Authors: Patrick M Keating Nicholas P Schifano Xinrui Wei Matthew Y Kong Jinwoo Lee Source Type: research
Combating the zoonotic trio of Ebola virus disease, Lassa fever, and COVID-19 in Nigeria: a retrospection of the challenges and lessons
Ann Med Surg (Lond). 2023 Jul 3;85(8):3955-3959. doi: 10.1097/MS9.0000000000001038. eCollection 2023 Aug.ABSTRACTVarious infectious disease outbreaks linked to zoonotic sources have been recorded over the years, some of which have resulted in epidemics on a national, regional, or global scale. In Africa, a number of such outbreaks occur intermittently, especially in countries like Nigeria with a high-risk of epidemiological transmission. Three viral outbreaks with zoonotic links have hit the Nigerian healthcare system hardest, which are the Ebola virus disease, Lassa fever and Coronavirus disease 2019. Due to the fragile n...
Source: Annals of Medicine - August 9, 2023 Category: Internal Medicine Authors: Emmanuel E Elebesunu Fortune B Effiong Marvellous O Asika Precious K Fadele Favour A Onyeogalu Charles A Okafor Godfred Y Scott Source Type: research
Investigating and combatting the key drivers of viral zoonoses in Africa: an analysis of eight epidemics
Braz J Biol. 2023 Jul 28;84:e270857. doi: 10.1590/1519-6984.270857. eCollection 2023.ABSTRACTInvestigating the interplay of factors that result in a viral zoonotic outbreak is difficult, though it is increasingly important. As anthropogenic influences shift the delicate balance of ecosystems, new zoonoses emerge in humans. Sub-Saharan Africa is a notable hotspot for zoonotic disease due to abundant competent mammalian reservoir hosts. Furthermore, poverty, corruption, and an overreliance on natural resources play considerable roles in depleting biological resources, exacerbating the population's susceptibility. Unsurprisin...
Source: Braz J Biol - August 2, 2023 Category: Biology Authors: P O Isibor O O Onwaeze I I Kayode-Edwards D O Agbontaen I-A M Ifebem-Ezima O Bilewu C Onuselogu A P Akinniyi Y D Obafemi M I Oniha Source Type: research
Investigating and combatting the key drivers of viral zoonoses in Africa: an analysis of eight epidemics
Braz J Biol. 2023 Jul 28;84:e270857. doi: 10.1590/1519-6984.270857. eCollection 2023.ABSTRACTInvestigating the interplay of factors that result in a viral zoonotic outbreak is difficult, though it is increasingly important. As anthropogenic influences shift the delicate balance of ecosystems, new zoonoses emerge in humans. Sub-Saharan Africa is a notable hotspot for zoonotic disease due to abundant competent mammalian reservoir hosts. Furthermore, poverty, corruption, and an overreliance on natural resources play considerable roles in depleting biological resources, exacerbating the population's susceptibility. Unsurprisin...
Source: Braz J Biol - August 2, 2023 Category: Biology Authors: P O Isibor O O Onwaeze I I Kayode-Edwards D O Agbontaen I-A M Ifebem-Ezima O Bilewu C Onuselogu A P Akinniyi Y D Obafemi M I Oniha Source Type: research
Investigating and combatting the key drivers of viral zoonoses in Africa: an analysis of eight epidemics
Braz J Biol. 2023 Jul 28;84:e270857. doi: 10.1590/1519-6984.270857. eCollection 2023.ABSTRACTInvestigating the interplay of factors that result in a viral zoonotic outbreak is difficult, though it is increasingly important. As anthropogenic influences shift the delicate balance of ecosystems, new zoonoses emerge in humans. Sub-Saharan Africa is a notable hotspot for zoonotic disease due to abundant competent mammalian reservoir hosts. Furthermore, poverty, corruption, and an overreliance on natural resources play considerable roles in depleting biological resources, exacerbating the population's susceptibility. Unsurprisin...
Source: Braz J Biol - August 2, 2023 Category: Biology Authors: P O Isibor O O Onwaeze I I Kayode-Edwards D O Agbontaen I-A M Ifebem-Ezima O Bilewu C Onuselogu A P Akinniyi Y D Obafemi M I Oniha Source Type: research
Investigating and combatting the key drivers of viral zoonoses in Africa: an analysis of eight epidemics
Braz J Biol. 2023 Jul 28;84:e270857. doi: 10.1590/1519-6984.270857. eCollection 2023.ABSTRACTInvestigating the interplay of factors that result in a viral zoonotic outbreak is difficult, though it is increasingly important. As anthropogenic influences shift the delicate balance of ecosystems, new zoonoses emerge in humans. Sub-Saharan Africa is a notable hotspot for zoonotic disease due to abundant competent mammalian reservoir hosts. Furthermore, poverty, corruption, and an overreliance on natural resources play considerable roles in depleting biological resources, exacerbating the population's susceptibility. Unsurprisin...
Source: Braz J Biol - August 2, 2023 Category: Biology Authors: P O Isibor O O Onwaeze I I Kayode-Edwards D O Agbontaen I-A M Ifebem-Ezima O Bilewu C Onuselogu A P Akinniyi Y D Obafemi M I Oniha Source Type: research
Investigating and combatting the key drivers of viral zoonoses in Africa: an analysis of eight epidemics
Braz J Biol. 2023 Jul 28;84:e270857. doi: 10.1590/1519-6984.270857. eCollection 2023.ABSTRACTInvestigating the interplay of factors that result in a viral zoonotic outbreak is difficult, though it is increasingly important. As anthropogenic influences shift the delicate balance of ecosystems, new zoonoses emerge in humans. Sub-Saharan Africa is a notable hotspot for zoonotic disease due to abundant competent mammalian reservoir hosts. Furthermore, poverty, corruption, and an overreliance on natural resources play considerable roles in depleting biological resources, exacerbating the population's susceptibility. Unsurprisin...
Source: Braz J Biol - August 2, 2023 Category: Biology Authors: P O Isibor O O Onwaeze I I Kayode-Edwards D O Agbontaen I-A M Ifebem-Ezima O Bilewu C Onuselogu A P Akinniyi Y D Obafemi M I Oniha Source Type: research
Investigating and combatting the key drivers of viral zoonoses in Africa: an analysis of eight epidemics
Braz J Biol. 2023 Jul 28;84:e270857. doi: 10.1590/1519-6984.270857. eCollection 2023.ABSTRACTInvestigating the interplay of factors that result in a viral zoonotic outbreak is difficult, though it is increasingly important. As anthropogenic influences shift the delicate balance of ecosystems, new zoonoses emerge in humans. Sub-Saharan Africa is a notable hotspot for zoonotic disease due to abundant competent mammalian reservoir hosts. Furthermore, poverty, corruption, and an overreliance on natural resources play considerable roles in depleting biological resources, exacerbating the population's susceptibility. Unsurprisin...
Source: Braz J Biol - August 2, 2023 Category: Biology Authors: P O Isibor O O Onwaeze I I Kayode-Edwards D O Agbontaen I-A M Ifebem-Ezima O Bilewu C Onuselogu A P Akinniyi Y D Obafemi M I Oniha Source Type: research
Investigating and combatting the key drivers of viral zoonoses in Africa: an analysis of eight epidemics
Braz J Biol. 2023 Jul 28;84:e270857. doi: 10.1590/1519-6984.270857. eCollection 2023.ABSTRACTInvestigating the interplay of factors that result in a viral zoonotic outbreak is difficult, though it is increasingly important. As anthropogenic influences shift the delicate balance of ecosystems, new zoonoses emerge in humans. Sub-Saharan Africa is a notable hotspot for zoonotic disease due to abundant competent mammalian reservoir hosts. Furthermore, poverty, corruption, and an overreliance on natural resources play considerable roles in depleting biological resources, exacerbating the population's susceptibility. Unsurprisin...
Source: Braz J Biol - August 2, 2023 Category: Biology Authors: P O Isibor O O Onwaeze I I Kayode-Edwards D O Agbontaen I-A M Ifebem-Ezima O Bilewu C Onuselogu A P Akinniyi Y D Obafemi M I Oniha Source Type: research
Investigating and combatting the key drivers of viral zoonoses in Africa: an analysis of eight epidemics
Braz J Biol. 2023 Jul 28;84:e270857. doi: 10.1590/1519-6984.270857. eCollection 2023.ABSTRACTInvestigating the interplay of factors that result in a viral zoonotic outbreak is difficult, though it is increasingly important. As anthropogenic influences shift the delicate balance of ecosystems, new zoonoses emerge in humans. Sub-Saharan Africa is a notable hotspot for zoonotic disease due to abundant competent mammalian reservoir hosts. Furthermore, poverty, corruption, and an overreliance on natural resources play considerable roles in depleting biological resources, exacerbating the population's susceptibility. Unsurprisin...
Source: Braz J Biol - August 2, 2023 Category: Biology Authors: P O Isibor O O Onwaeze I I Kayode-Edwards D O Agbontaen I-A M Ifebem-Ezima O Bilewu C Onuselogu A P Akinniyi Y D Obafemi M I Oniha Source Type: research
Investigating and combatting the key drivers of viral zoonoses in Africa: an analysis of eight epidemics
Braz J Biol. 2023 Jul 28;84:e270857. doi: 10.1590/1519-6984.270857. eCollection 2023.ABSTRACTInvestigating the interplay of factors that result in a viral zoonotic outbreak is difficult, though it is increasingly important. As anthropogenic influences shift the delicate balance of ecosystems, new zoonoses emerge in humans. Sub-Saharan Africa is a notable hotspot for zoonotic disease due to abundant competent mammalian reservoir hosts. Furthermore, poverty, corruption, and an overreliance on natural resources play considerable roles in depleting biological resources, exacerbating the population's susceptibility. Unsurprisin...
Source: Braz J Biol - August 2, 2023 Category: Biology Authors: P O Isibor O O Onwaeze I I Kayode-Edwards D O Agbontaen I-A M Ifebem-Ezima O Bilewu C Onuselogu A P Akinniyi Y D Obafemi M I Oniha Source Type: research
Investigating and combatting the key drivers of viral zoonoses in Africa: an analysis of eight epidemics
Braz J Biol. 2023 Jul 28;84:e270857. doi: 10.1590/1519-6984.270857. eCollection 2023.ABSTRACTInvestigating the interplay of factors that result in a viral zoonotic outbreak is difficult, though it is increasingly important. As anthropogenic influences shift the delicate balance of ecosystems, new zoonoses emerge in humans. Sub-Saharan Africa is a notable hotspot for zoonotic disease due to abundant competent mammalian reservoir hosts. Furthermore, poverty, corruption, and an overreliance on natural resources play considerable roles in depleting biological resources, exacerbating the population's susceptibility. Unsurprisin...
Source: Braz J Biol - August 2, 2023 Category: Biology Authors: P O Isibor O O Onwaeze I I Kayode-Edwards D O Agbontaen I-A M Ifebem-Ezima O Bilewu C Onuselogu A P Akinniyi Y D Obafemi M I Oniha Source Type: research
Investigating and combatting the key drivers of viral zoonoses in Africa: an analysis of eight epidemics
Braz J Biol. 2023 Jul 28;84:e270857. doi: 10.1590/1519-6984.270857. eCollection 2023.ABSTRACTInvestigating the interplay of factors that result in a viral zoonotic outbreak is difficult, though it is increasingly important. As anthropogenic influences shift the delicate balance of ecosystems, new zoonoses emerge in humans. Sub-Saharan Africa is a notable hotspot for zoonotic disease due to abundant competent mammalian reservoir hosts. Furthermore, poverty, corruption, and an overreliance on natural resources play considerable roles in depleting biological resources, exacerbating the population's susceptibility. Unsurprisin...
Source: Braz J Biol - August 2, 2023 Category: Biology Authors: P O Isibor O O Onwaeze I I Kayode-Edwards D O Agbontaen I-A M Ifebem-Ezima O Bilewu C Onuselogu A P Akinniyi Y D Obafemi M I Oniha Source Type: research
