Klinefelter's Syndrome Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

In vitro spermatogenesis in artificial testis: current knowledge and clinical implications for male infertility
AbstractMen ’s reproductive health exclusively depends on the appropriate maturation of certain germ cells known as sperm. Certain illnesses, such as Klinefelter syndrome, cryptorchidism, and syndrome of androgen insensitivity or absence of testis maturation in men, resulting in the loss of germ cells and the removal of essential genes on the Y chromosome, can cause non-obstructive azoospermia. According to laboratory research, preserving, proliferating, differentiating, and transplanting spermatogonial stem cells or testicular tissue could be future methods for preserving the fertility of children with cancer and men wi...
Source: Cell and Tissue Research - September 18, 2023 Category: Cytology Source Type: research

TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells
ConclusionsTLR8, mirroringTLR7, escapes XCI in human monocytes and CD4+ T cells. Co-dependent transcription from the active X chromosome and escape from XCI could both contribute to higher TLR8 protein abundance in female cells, which may have implications for the response to viruses and bacteria, and the risk of developing inflammatory and autoimmune diseases. (Source: Biology of Sex Differences)
Source: Biology of Sex Differences - September 18, 2023 Category: Biology Source Type: research

A rare case of mosaic Klinefelter syndrome in a 45-year-old man leading to successful live birth through ejaculated spermatozoa: a case report and literature review
Conclusion: Although this case is exceedingly rare, it underscores the critical importance of exhausting all possibilities to facilitate biological parenthood in men with KS before considering alternative options such as sperm donation or adoption. By recognizing the potential for successful conception using ejaculated sperm in this population, we can provide individuals with mosaic KS the opportunity to fulfill their desire for biological offspring. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - September 13, 2023 Category: Genetics & Stem Cells Source Type: research

Single-cell RNA sequencing technology in human spermatogenesis: Progresses and perspectives
Mol Cell Biochem. 2023 Sep 2. doi: 10.1007/s11010-023-04840-x. Online ahead of print.ABSTRACTSpermatogenesis, a key part of the spermiation process, is regulated by a combination of key cells, such as primordial germ cells, spermatogonial stem cells, and somatic cells, such as Sertoli cells. Abnormal spermatogenesis can lead to azoospermia, testicular tumors, and other diseases related to male infertility. The application of single-cell RNA sequencing (scRNA-seq) technology in male reproduction is gradually increasing with its unique insight into deep mining and analysis. The data cover different periods of neonatal, prepu...
Source: Molecular and Cellular Biochemistry - September 2, 2023 Category: Biochemistry Authors: Hanbo Jia Wei Wang Zhaowen Zhou Zhiyi Chen Zijun Lan Hao Bo Liqing Fan Source Type: research

Subjective versus objective sleep in men with Klinefelter syndrome
To investigate sleep among men with Klinefelter syndrome (KS). (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - September 1, 2023 Category: Internal Medicine Authors: K. W. Fjermestad, R. R. Finnbakk, A.-K. Solbakk, C. H. Gravholt and R. J. Huster Tags: Research Source Type: research

Executive dysfunction in Klinefelter syndrome: associations with brain activation and testicular failure
CONCLUSION: These findings indicate a neural basis for executive dysfunction in KS and suggest alterations in pubertal development may contribute to increased severity of this cognitive weakness. Future studies that examine whether these patterns change with testosterone replacement therapy are warranted.PMID:37595261 | DOI:10.1210/clinem/dgad487 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 18, 2023 Category: Endocrinology Authors: Lara C Foland-Ross Elnaz Ghasemi Vanessa Lozano Wun Tandy Aye Karen Kowal Judith Ross Allan L Reiss Source Type: research

Prevalence of Chromosomal Abnormalities in Iranian Patients with Infertility
CONCLUSION: In general, we found a high prevalence of chromosomal abnormalities in Iranian patients with reproductive problems. Our study highlights the importance of cytogenetic studies in infertile patients before starting infertility treatments approaches.PMID:37543931 | DOI:10.34172/aim.2023.17 (Source: Archives of Iranian Medicine)
Source: Archives of Iranian Medicine - August 6, 2023 Category: Middle East Health Authors: Saima Abbaspour Alireza Isazadeh Matin Heidari Masoud Heidari Saba Hajazimian Morteza Soleyman-Nejad Mohammad Hossein Taskhiri Manzar Bolhassani Amir Hossein Ebrahimi Parvaneh Keshavarz Zahra Shiri Mansour Heidari Source Type: research