Fight Aging! Newsletter, July 1st 2019
In this study, we determine whether transient reintroduction of embryonic stem cell cycle miR-294 promotes cardiomyocyte cell cycle reentry enhancing cardiac repair after myocardial injury. A doxycycline-inducible AAV9-miR-294 vector was delivered to mice for activating miR-294 in myocytes for 14 days continuously after myocardial infarction. miR-294-treated mice significantly improved left ventricular functions together with decreased infarct size and apoptosis 8 weeks after MI. Myocyte cell cycle reentry increased in miR-294 hearts parallel to increased small myocyte number in the heart. Isolated adult myocytes from miR-...
Source: Fight Aging! - June 30, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Goal of Kidney Rejuvenation
The authors of this open access paper review the aging of the kidney and consider the prospects for using factors from young blood as a means of rejuvenation. This is a fairly narrow view, as there are many other approaches that should produce rejuvenation of the aged kidney, ranging from those close to realization, such as senolytic therapies to clear senescent cells, or various approaches to stem cell therapy, to those yet to be achieved, meaning much of the rest of the SENS agenda of rejuvenation biotechnologies to repair the damage that causes aging. Nonetheless, after so many years of trying to persuade the research c...
Source: Fight Aging! - June 24, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Last Month in Oncology with Dr. Bishal Gyawali: April 2019
By BISHAL GYAWALI, MD
Keynote speech on the JAVELIN not going far enough to improve survival
The treatment landscape for metastatic renal-cell carcinoma has changed dramatically with the introduction of immunotherapies. Unfortunately though, we are promoting combinations over single agents without having much idea of added benefit of each drug. This is an important issue because when we combine two drugs, the only thing we are certain of are the added toxicities. PD-1 inhibitor nivolumab had improved OS when given in second line, however nivolumab was tested in combination with ipilimumab (not as a nivolumab monother...
Source: The Health Care Blog - May 10, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Bishal Gyawali Clinical Trials Oncology PD-1 inhibitor Source Type: blogs
Cancer treatment: Is a clinical trial right for you?
Clinical trials are research studies that test a new drug or therapy in patients who have a disease. These studies are classified as phase I, II, or III depending on their purpose.
Phase I: These initial, small studies test promising new drugs that effectively kill cancer cells in laboratory experiments. The goal is to understand the safe dose and capture early evidence of benefit. Phase I trials may be open to patients with any type of cancer, or only certain types of cancers more likely to respond to specific drugs. Generally, fewer than 50 patients are enrolled.
Phase II: Once a phase I trial identifies a safe dose, ...
Source: Harvard Health Blog - March 22, 2019 Category: Consumer Health News Authors: Guru P. Sonpavde, MD Tags: Breast Cancer Health Treatments Source Type: blogs
Fight Aging! Newsletter, March 18th 2019
This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases.
There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
Source: Fight Aging! - March 17, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Engineering of Kidney Organoids Proceeds Apace
This is the organoid era of tissue engineering. Researchers are making earnest progress in establishing the recipes that allow cells to be grown into small, functional tissue sections. They lack a network of capillaries, however, so must be no more than a millimeter or so in thickness in order for nutrients to perfuse sufficiently through the tissue to support all of its cells. Every organ, every tissue has a significantly different recipe, but it is usually something that can be derived from an examination of the biochemistry of embryonic growth, with enough time and funding. Given the large number of different tissues ve...
Source: Fight Aging! - March 12, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Why You Might Get Kidney Cancer If You Move To Florida
About one in fifty people reading this essay will be diagnosed with kidney cancer at some time in their life. In fact, one out of one people writing this essay has already been diagnosed with kidney cancer. (I had a small tumor … Continue reading →
The post Why You Might Get Kidney Cancer If You Move To Florida appeared first on PeterUbel.com. (Source: blog.bioethics.net)
Source: blog.bioethics.net - December 19, 2018 Category: Medical Ethics Authors: PeterUbel.com Tags: Health Care Critical Decisions health policy Peter Ubel syndicated Uncategorized Source Type: blogs
Last Month in Oncology with Dr. Bishal Gyawali
By BISHAL GYAWALI MD
Me-too deja vu
I read the report of a phase 3 RCT of a “new” breast cancer drug but I had the feeling that I had already read this before. Later I realized that this was indeed a new trial of a new drug, but that I had read a very similar report of a very similar drug with very similar results and conclusions. This new drug is a PARP inhibitor called talazoparib and the deja vu was related to another PARP inhibitor drug called olaparib tested in the same patient population of advanced breast cancer patients with a BRCA mutation. The control arms were the same: physician choice of drug, except t...
Source: The Health Care Blog - November 8, 2018 Category: Consumer Health News Authors: matthew holt Tags: Drug Discovery Pharmaceuticals Bishal Gyawali Cancer immunotherapy Oncology Source Type: blogs
A CT scan for kidney cancer? It may depend on where you live.
About one in fifty people reading this essay will be diagnosed with kidney cancer at some time in their life. In fact, one out of one people writing this essay has already been diagnosed with kidney cancer. (I had a small tumor removed from my left kidney not long after I turned 50.) But how many people […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 8, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/peter-ubel" rel="tag" > Peter Ubel, MD < /a > Tags: Conditions Nephrology Oncology/Hematology Source Type: blogs
Are You Going To Wake Up From Cryosleep?
More than 300 people let their bodies have cooled down to -200 Celsius and preserved in liquid nitrogen in the hope that someday in the future, science will be able to cheat death and make them wake up from their Sleeping Beauty state. As of today, no one knows whether they will ever have the chance for a second life. Here’s our overview of cryonics, cryosleep, and cryotherapy.
Relax, David, open your eyes!
That’s the last line from Vanilla Sky, the movie remake about a wealthy playboy in cryosleep waking up after 150 years from his lucid dream (starring Tom Cruise as David). The audience doesn’t know what happens ne...
Source: The Medical Futurist - October 17, 2018 Category: Information Technology Authors: nora Tags: Bioethics Cyborgization Medical Science Fiction Patients Researchers Space Medicine cryogenics cryonics cryosleep cryotherapy death future Innovation life longevity mars NASA scifi space travel Source Type: blogs
August 2010 Man of the Month: E-Patient Dave
Richard Davies deBronkart Jr , known by many as e-Patient Dave, is a cancer patient and blogger who, in 2009, became a noted activist for health care transformation through participatory medicine and personal health data rights. In 2010, he became a published author and Disruptive Women in Health Care’s August Man of the Month.
I was a middle-aged guy going through life, as involved with my own health care as I was with my car’s carburetor, which is to say, virtually not at all. And then I found out I was almost dead.
That’s how my interview with Dave started.
Dave was diagnosed in January 2007 with Stage IV, Grade 4...
Source: Disruptive Women in Health Care - September 27, 2018 Category: Consumer Health News Authors: dw at disruptivewomen.net Tags: Uncategorized Source Type: blogs
Researchers Develop Protocol That Improves Bone Metastases Detection by 30 Percent
At the University of Texas Southwestern Medical Center, researchers have developed a new magnetic resonance imaging (MRI) technique that improves the detection of bone metastases in the body and is a quicker process than a conventional MRI scan.Bone metastases consist of abnormal cells from the initial tumor site, and occurwhen the tumor spreads to the bone. Bone metastases can weaken and break bones, cause numbness, weakness, and compress the spinal cord. The condition can also have negative consequences on the bone marrow. Swift detection of bone metastases can prevent these symptoms. However, timely detection can be c...
Source: radRounds - September 13, 2018 Category: Radiology Authors: Julie Morse Source Type: blogs
Fight Aging! Newsletter, August 13th 2018
We report that the disruption of excitation-contraction coupling contributes to impaired force generation in the mouse model of Sod1 deficiency. Briefly, we found a significant reduction in sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity as well as reduced expression of proteins involved in calcium release and force generation. Another potential factor involved in EC uncoupling in Sod1-/- mice is oxidative damage to proteins involved in the contractile response.
In summary, this study provides strong support for the coupling between increased oxidative stress and disruption of cellular excitation contraction mac...
Source: Fight Aging! - August 12, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Attempts Continue to Link Blood Group to Natural Variations in Longevity
If we are to judge from the findings of genetic association studies, natural variation in human longevity occurs due to countless distinct factors, each of which provides a small contribution, is highly dependent on environmental circumstances, and is highly linked to other factors. Scientists have struggled to replicate more than a few known associations across different study populations, and those that have been replicated between study groups have small effects.
Blood group is genetically determined, and data on patient blood group is included in many of the data sets that report on disease incidence and mortali...
Source: Fight Aging! - August 6, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The March of Legal Settlements Made by Pharmaceutical Companies is Diminishing - Presaging Even Less Accountablity for Top Health Care Organizational Leaders?
DiscussionSo my perceptions that the number of the sorts of legal settlements of interest to us has likely been diminishing was accurate. Unfortunately, rather than the decrease being due to better behavior, decresed reporting, or my laxity in case-finding, it now looks that US government efforts to combat bad behavior by big health care corporations and to hold top leaders of these organizations accountable is getting even more lax.So once again, with feeling... We seem to be sliding backwards in efforts to make the leaders of large health care organizations accountable, and particularly to combat the worse man...
Source: Health Care Renewal - May 25, 2018 Category: Health Management Tags: Donald Trump health care prices impunity kickbacks legal settlements Pfizer Source Type: blogs
