Ninjinyoeito exerts an antidepressant ‐like effect by enhancing the central noradrenergic system
ConclusionNYT reduced immobility time in the tail suspension test, likely by increasing NE levels. The increased NE levels may activate the α1-adrenoceptor, thereby ameliorating the depression-like behavior. NYT may therefore improve depressive symptoms in patients by enhancing the noradrenergic system. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - January 15, 2022 Category: Complementary Medicine Authors: Soichiro Tsutsumi, Takuya Watanabe, Akinobu Hatae, Marika Hirata, Hiroya Omori, Chise Taniguchi, Masaki Nagao, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki Tags: ORIGINAL ARTICLE Source Type: research

Safety of jidabokuippo administration based on adverse event rate
ConclusionThe adverse event rate associated with JDI use was low and onset was relatively rapid. We can further reduce this adverse event rate by paying attention to the pharmacological action of rhubarb rhizome andGlycyrrhiza root. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - January 5, 2022 Category: Complementary Medicine Authors: Toshiharu Kitamura, Hajime Nakae, Yasuhito Irie, Kasumi Satoh, Nobuhisa Hirasawa, Koumei Kameyama, Yuya Suzuki, Kyohei Maeno, Kenji Yoshida, Manabu Okuyama Tags: ORIGINAL ARTICLE Source Type: research

Premenstrual syndrome and dysmenorrhea successfully managed with the Japanese traditional medicine tokito: A case report and literature review
ConclusionTokito may become a viable option for treating or preventing PMS symptoms and dysmenorrhea. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - December 21, 2021 Category: Complementary Medicine Authors: Shiho Fukai ‐Watabe, Satoru Ishibashi, Tokumu Watabe, Hirotsugu Watabe Tags: CASE REPORT Source Type: research

Issue Information
(Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - December 2, 2021 Category: Complementary Medicine Tags: ISSUE INFORMATION Source Type: research

Effects of microbial fermentation on enzyme activity and volatile properties of Massa Medicata Fermentata
ConclusionMicrobial fermentation contributes to increased enzyme activity and changes in MMF volatiles. These properties of MMF were considerably affected by the microbes used, and it is proposed in this study that it is important to have microbial control in the production of commercial MMF. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - December 1, 2021 Category: Complementary Medicine Authors: Zitai Wang, Kayu Okutsu, Yumiko Yoshizaki, Taiki Futagami, Hisanori Tamaki, Takuro Maruyama, Kazufumi Toume, Katsuko Komatsu, Fumio Hashimoto, Kazunori Takamine Tags: ORIGINAL ARTICLE Source Type: research

Efficacy of Aconiti tuber for chemotherapy ‐induced peripheral neuropathy with peripheral coldness and/or symptoms relief by warming: A case series
ConclusionBushi is effective for CIPN in cancer patients. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - November 18, 2021 Category: Complementary Medicine Authors: Tatsuto Terada, Tomofumi Miura, Kazuhiro Kosugi, Maika Natsume, Midori Y. Yajima, Yasutaka Shimotsuura, Tetsuya Eto, Yoshihisa Matsumoto Tags: CASE REPORT Source Type: research

Lack of inhibitory effect of wood creosote on cytochrome P450 ‐mediated drug metabolism
ConclusionThese results suggest that clinical doses of WC are unlikely to cause drug interactions mediated by the inhibition of CYPs. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - November 16, 2021 Category: Complementary Medicine Authors: Hirokazu Chokki, Yuki Nishimura, Mariko Iwase, Norimitsu Kurata, Koichiro Shinya, Mayumi Tsuji, Masafumi Ito, Mutsumi Asai, Hirofumi Morino, Takanori Miura, Takashi Shibata, Yuji Kiuchi Tags: ORIGINAL ARTICLE Source Type: research

Kamishoyosan is effective for female patients with oral and nasal cavity problems
ConclusionKSS is effective for female patients with oral and nasal cavity problems. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - November 12, 2021 Category: Complementary Medicine Authors: Hidenori Tanaka, Yasuhito Irie, Hajime Nakae Tags: CASE REPORT Source Type: research

Acute appendicitis in an elderly patient treated with choyoto in combination with conservative antibiotic therapy
ConclusionConservative treatment without surgery for acute appendicitis is risky in the elderly because of the possibility of a malignancy and because the severity of the disease tends to be underestimated. On the other hand, the risk of postoperative complications is high due to comorbidities. Therefore, In order to solve this dilemma, the effectiveness of the combination of Kampo medicines with conservative antibiotic therapy in improving symptoms and preventing recurrence should be verified. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - October 2, 2021 Category: Complementary Medicine Authors: Yasuhito Irie, Tasuku Nara, Kasumi Satoh, Koumei Kameyama, Toshiharu Kitamura, Manabu Okuyama, Hajime Nakae Tags: CASE REPORT Source Type: research

Effectiveness of goreisan –jiinkokato combination for an elderly patient with heart failure: A case report
ConclusionsGoreisan –jiinkokato combination therapy may be effective for the treatment of elderly patients with heart failure. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - September 21, 2021 Category: Complementary Medicine Authors: Dai Katayose Tags: CASE REPORT Source Type: research

Kamikihito improves cancer ‐related fatigue in castration‐resistant prostate cancer patients receiving enzalutamide: Multidimensional approach including metabolomics analysis
ConclusionKamikihito corrected the abnormalities in lipid metabolism, which may have improved the production of amino acids, leading to reduced CRF in CRPC patients receiving enzalutamide. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - September 16, 2021 Category: Complementary Medicine Authors: Satoshi Tamada, Taro Iguchi, Minoru Kato, Takeshi Yamasaki, Naoko Tsuchiya, Katsuya Ohbuchi, Chika Shimobori, Junzo Nojima, Sayaka Yasuda, Kyoko Ebisu, Yasuyoshi Watanabe Tags: ORIGINAL ARTICLE Source Type: research

Effects of Perilla frutescens var. crispa herb extract, the essential oil perillaldehyde, and the caffeetannin rosmarinic acid on gastric emptying and gastrointestinal motility in mice
ConclusionIn this study, rosmarinic acid in Perilla herb may be effective for functional dyspepsia. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - August 26, 2021 Category: Complementary Medicine Authors: Yoshiyuki Kimura, Masahiko Taniguchi Tags: ORIGINAL ARTICLE Source Type: research

Examination of the molecular mechanism of the mutual inhibitory effect of each cytotoxicity caused by the combined extraction of Coptidis Rhizoma and Rhei Rhizoma: An example of providing evidence for ‘herbal pair’ theory
ConclusionFrom these results, when CR and RR are extracted together, their cytotoxicity is suppressed by some unknown mechanism. Whether this is due to the synthesis of new compounds by co-extraction or the detoxification of toxic components by interaction needs further investigation. This result suggests the importance of ‘herbal pair’ research. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - August 16, 2021 Category: Complementary Medicine Authors: Rena Suzuki, Qingfeng Zhao, Haruka Hosokai, Michihisa Tohda Tags: ORIGINAL ARTICLE Source Type: research

Kampo medicine can improve quality of life and prolong hemodialysis implementation in patients with advanced ‐stage chronic kidney disease
ConclusionRegular HD implementation was prolonged in advanced CKD patients using KM; thus, it is a supportive therapy for advanced CKD patients. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - August 7, 2021 Category: Complementary Medicine Authors: Masayuki Shimizu, Shin Takayama, Kota Ishizawa, Michiaki Abe, Tadashi Ishii Tags: CASE REPORT Source Type: research

Kampo medicine prescriptions for hospitalized patients in Tohoku University Hospital
ConclusionKampo Medicines were prescribed for specific diseases or conditions at various inpatient departments in the university hospital. (Source: Traditional and Kampo Medicine)
Source: Traditional and Kampo Medicine - August 7, 2021 Category: Complementary Medicine Authors: Ryo Sugimine, Yuna Kikukawa, Daisuke Kurihara, Ryutaro Arita, Shin Takayama, Akiko Kikuchi, Minoru Ohsawa, Tadashi Ishii Tags: SHORT COMMUNICATION Source Type: research