Helicobacter pylori DNA promotes cellular proliferation, migration, and invasion of gastric cancer by activating toll-like receptor 9
Conclusions: The present results suggest that the H. pylori DNA/TLR9-signaling pathway plays an important role in gastric cancer, which might be a potential therapeutic target. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - May 12, 2019 Category: Gastroenterology Authors: Xiang-Rong Qin Jia Wu Xin-Yu Yao Jin Huang Xiao-Yong Wang Source Type: research

Outcome of biliary atresia among Saudi children: A tertiary care center experience
Conclusion: BA is an uncommon cause of infantile cholestasis in Saudi Arabia. Our study provides a snapshot of the epidemiology of BA in Saudi Arabia that is characterized by late referral to pediatric gastroenterologists and poor outcome without LT. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - May 12, 2019 Category: Gastroenterology Authors: Sinan Holdar Badr Alsaleem Ali Asery Abdulrahman Al-Hussaini Source Type: research

Cytochrome P450 family members are associated with fast-growing hepatocellular carcinoma and patient survival: An integrated analysis of gene expression profiles
Conclusions: In summary, our results confirmed for the first time that a four-CYP gene (CYP1A2, CYP2E1, CYP2A7, and PTGIS) signature is associated with fast-growing HCC, and CYP2C8 is associated with patient survival. Our findings could help to identify HCC patients at high risk of rapid growth and recurrence. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - May 12, 2019 Category: Gastroenterology Authors: Zhao-Zhen Liu Li-Na Yan Chun-Nan Dong Ning Ma Mei-Na Yuan Jin Zhou Ping Gao Source Type: research

Maladaptive coping, low self-efficacy and disease activity are associated with poorer patient-reported outcomes in inflammatory bowel disease
Conclusion: Disease activity and modifiable psychological constructs are associated with unfavorable PRO in patients with IBD. These factors could assist with identifying high-risk patients, many of whom may benefit from targeted interventions to improve health outcomes. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - May 12, 2019 Category: Gastroenterology Authors: Che-Yung Chao Carolyne Lemieux Sophie Restellini Waqqas Afif Alain Bitton Peter L Lakatos Gary Wild Talat Bessissow Source Type: research

The role of imaging in determining prognosis for primary sclerosing cholangitis: A systematic review
Conclusion: In conclusion, ERCP and MRCP-based indices have short-term prognostic value in PSC. However, more studies are required to validate their predictability of disease-related progression, such as liver decompensation, ascending cholangitis, cholangiocarcinoma and liver transplantation. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - May 12, 2019 Category: Gastroenterology Authors: Dan Segal Paul Marotta Mahmoud Mosli Guangyong Zou Brian G Feagan Bandar Al-Judaibi Source Type: research

The regulatory roles of long noncoding RNAs in the biological behavior of pancreatic cancer
Ying Li, Xiaojuan Yang, Xiaoning Kang, Shanglong LiuSaudi Journal of Gastroenterology 2019 25(3):145-151 Long noncoding RNAs (lncRNAs) are a new class of regulators. LncRNAs are defined as endogenous transcribed RNA molecules with transcript length of >200 nt. Accumulating evidence has shown that lncRNAs are involved in many physiological processes such as cell cycle regulation, cell apoptosis and survival, cancer migration and metabolism. However, the biological and molecular mechanisms of lncRNAs in pancreatic cancer are still unclear. Recent studies have reported that many lncRNAs are dysregulated in pancrea...
Source: The Saudi Journal of Gastroenterology - May 12, 2019 Category: Gastroenterology Authors: Ying Li Xiaojuan Yang Xiaoning Kang Shanglong Liu Source Type: research

The missing & #8220;C & #8221;: Crohn & #39;s, colitis and coping
Turki AlAmeel, Mahmoud MosliSaudi Journal of Gastroenterology 2019 25(3):143-144 (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - May 12, 2019 Category: Gastroenterology Authors: Turki AlAmeel Mahmoud Mosli Source Type: research

Chronic hepatitis B patients: A relation of age and comorbidities
Ashish K Vyas, Anirudh K SinghSaudi Journal of Gastroenterology 2019 25(2):141-141 (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - March 25, 2019 Category: Gastroenterology Authors: Ashish K Vyas Anirudh K Singh Source Type: research

Precision medicine in colorectal cancer
Mohammad Azhar AzizSaudi Journal of Gastroenterology 2019 25(2):139-140 (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - March 25, 2019 Category: Gastroenterology Authors: Mohammad Azhar Aziz Source Type: research

Predictors of failure of endoscopic retrograde cholangiography in clearing bile duct stone on the initial procedure
Conclusion: A few of the characteristics that are found on cholangiography at the index ERCP could be used to identify patients that might require more than one ERCP to clear the biliary system from stones. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - March 25, 2019 Category: Gastroenterology Authors: Majid A Almadi Mohanned Eltayeb Salem Thaniah Faisal Alrashed Mohammad A Aljebreen Othman R Alharbi Nahla Azzam Abdulrahman M Aljebreen Source Type: research

Accuracy of invasive and noninvasive methods of Helicobacter pylori infection diagnosis in Saudi children
Conclusion: RUT is a valuable diagnostic method for identifying H. pylori with the highest sensitivity compared to AD and SAT. All diagnostic tests showed moderate-to-high specificities but BC and histology showed the highest specificity. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - March 25, 2019 Category: Gastroenterology Authors: Mohammed Hasosah Source Type: research

Circular RNA ARHGAP26 is over-expressed and its downregulation inhibits cell proliferation and promotes cell apoptosis in gastric cancer cells
Conclusion: The circ-ARHGAP26 is over-expressed and its downregulation inhibits cell proliferation and promotes cells apoptosis in GC cells. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - March 25, 2019 Category: Gastroenterology Authors: LV Wangxia Yang Fang Yongjun Liu Yazhen Zhao Zhong Shi Haijun Zhong Source Type: research

Presence of pink-color sign within 1 min after iodine staining has high diagnostic accordance rate for esophageal high-grade intraepithelial neoplasia/invasive cancer
Conclusion: Appearance of the PCS within 1 min after iodine staining has a higher diagnostic accordance rate for esophageal HGIN/invasive cancer than appearance of the PCS at 2 min. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - March 25, 2019 Category: Gastroenterology Authors: Jia-Yao Zheng Ya-Hua Chen Yang-Yang Chen Xiao-Ling Zheng Shi-Shun Zhong Wan-Yin Deng Jin-Hui Zheng Xian-Bin Guo Li-Ying Gao Wei Liang Source Type: research

Major bleeding risk of endoscopic sphincterotomy versus endoscopic papillary balloon dilatation in hemodialysis patients
Conclusion: Post-ERCP, post-EST, and post-EPBD major bleeding rates were all higher in HD patients in this study. EPBD resulted in lower postprocedure major bleeding events than EST in the non-HD population, but it failed to provide the reduction in bleeding events needed to perform endoscopic hemostasis in HD patients. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - March 25, 2019 Category: Gastroenterology Authors: Ming-Chang Tsai Chi-Chih Wang Yao-Tung Wang Tzu-Wei Yang Hsuan-Yi Chen Ming-Hseng Tseng Chun-Che Lin Source Type: research

& #945;-Smooth muscle actin expression predicts the outcome of Kasai portoenterostomy in biliary atresia
Conclusion: α-SMA expression may be a potential predictor of jaundice clearance and native liver survival after KPE. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - March 25, 2019 Category: Gastroenterology Authors: Priya Ramachandran Ashitha K Unny Mukul Vij Mohamed Safwan Muthukrishnan Saravana Balaji Mohamed Rela Source Type: research