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Gastrointestinal and liver manifestations of COVID-19
Janice Cheong, Nichoals Bartell, Thoetchai Peeraphatdit, Mahmoud Mosli, Bandar Al-JudaibiSaudi Journal of Gastroenterology 2020 26(5):226-232 The novel coronavirus 2 (SARS-CoV-2) has spread worldwide. While patients typically present with fever and symptoms of a respiratory illness, patients have also presented with gastrointestinal symptoms such as diarrhea, vomiting and abdominal pain. In addition, some patients were reported to have liver injury. In this article, we review gastrointestinal and liver aspects of COVID-19. In addition, we provide general gastroenterologists with guidance on the management of patients with...
Source: The Saudi Journal of Gastroenterology - September 17, 2020 Category: Gastroenterology Authors: Janice Cheong Nichoals Bartell Thoetchai Peeraphatdit Mahmoud Mosli Bandar Al-Judaibi Source Type: research

COVID-19 in gastroenterology and hepatology: Living with the realities of a historic 21st century pandemic
Eric M Yoshida, Trana Hussaini, Majid AlsahafiSaudi Journal of Gastroenterology 2020 26(5):223-225 (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - September 17, 2020 Category: Gastroenterology Authors: Eric M Yoshida Trana Hussaini Majid Alsahafi Source Type: research

LncRNA NEAT1 modulates sorafenib resistance in hepatocellular carcinoma through regulating the miR-149-5p/AKT1 axis
Conclusions: NEAT1/miR-149-5p/AKT1 pathway-based therapy might be a potential clinical application for HCC patients. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - July 28, 2020 Category: Gastroenterology Authors: Yuexiang Niu Gongen Tang Xiuli Wu Chaoyu Wu Source Type: research

Utility of inflammatory markers to predict adverse outcome in acute pancreatitis: A retrospective study in a single academic center
Conclusion: Our data show persistently low LMR that is associated with severe AP and a value of <2.0 can be used clinically to predict severe AP on admission. It also shows that elevated NLR is associated with complicated AP and prolonged hospital stay with a value >10.5 that can be used to predict severe complicated AP and to monitor response to treatment over time. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - July 28, 2020 Category: Gastroenterology Authors: Mohamad Mubder Banreet Dhindsa Danny Nguyen Syed Saghir Chad Cross Ranjit Makar Gordon Ohning Source Type: research

Risk of neutropenia in inflammatory bowel disease patients treated with TNF inhibitors: A single-center, retrospective cohort study
Conclusions: In this study, mild neutropenia was common among patients with IBD on TNFi. Future prospective studies are required to further clarify the significance of neutropenia in patients with IBD receiving TNFi. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - July 28, 2020 Category: Gastroenterology Authors: Dimah AlAskar Mais AlSardi Eman Al Sulais Mahmoud Mosli Turki AlAmeel Source Type: research

Prevalence of biopsy-proven nonalcoholic fatty liver among patients with gallstone disease
Conclusions: The prevalence of NAFLD among GD patients is high. High BMI and diabetes are independent factors associated with NAFLD in GD patients. The results suggest that there may be a need for routine liver biopsy in selected patients during cholecystectomy. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - July 28, 2020 Category: Gastroenterology Authors: Faisal A Alsaif Sara H Alqahtani Amani M Alsadoon Khalid A Alswat Ayman A Abdo Mazen M Hassanain Abdulsalam B Alsharabi Ghadeer R Aljuhani Hisham M Alkhalidi Mohammad S Elsharkawy Maram A Alotaibi Faisal M Sanai Waleed K Al-hamoudi Source Type: research

Biliary anatomy and pancreatic duct variations: A cross-sectional study
Conclusion: Variations in biliary anatomy and pancreatic duct are very diverse and extend from the intrahepatic biliary system down to the pancreas. Performing a similar study on a larger population is mandatory to illustrate the range of variations present within the community. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - July 28, 2020 Category: Gastroenterology Authors: Murad Aljiffry Mohammad Abbas Mohammad A. M. Wazzan Ahmed H Abduljabbar Safiyah Aloufi Emad Aljahdli Source Type: research

Development and validation of metric-based-training to proficiency simulation curriculum for upper gastrointestinal endoscopy using a novel assessment checklist
Conclusion: The Fundamentals of Gastrointestinal Endoscopy simulation training curriculum and its SESAS global assessment tool have been primarily validated and can serve as a valuable addition to the gastroenterology fellowship programs. Follow up study of trainee performance in workplaces is recommended for consequences validation. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - July 28, 2020 Category: Gastroenterology Authors: Nahla Azzam Nehal Khamis Majid Almadi Faisal Batwa Fahad Alsohaibani Abdulrahman Aljebreen Ahmad Alharbi Yasser Alaska Turki Alameel Peter Irving Richard M Satava Source Type: research

The association between SNPs rs1800591 and rs3816873 of the MTTP gene and nonalcoholic fatty liver disease: A meta-analysis
Conclusion: The present meta-analysis revealed that the rs1800591 and rs3816873 polymorphisms of the MTTP gene are uncommon in NAFLD. However, the G allele of rs1800591 was more likely to be correlated to NASH susceptibility. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - July 28, 2020 Category: Gastroenterology Authors: Jie Tan Jian Zhang Zhenzhen Zhao Jie Zhang Mengzhen Dong Xuefeng Ma Shousheng Liu Yongning Xin Source Type: research

Training to competency: Are we ready for a radical reform ?
Hani LababidiSaudi Journal of Gastroenterology 2020 26(4):169-170 (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - July 28, 2020 Category: Gastroenterology Authors: Hani Lababidi Source Type: research

Circulating tumor cells in whole process management of gastrointestinal stromal tumor in a real-life setting
Conclusions: In the current study, we assessed the CTCs and CTM of GIST patients in various disease progressions and identified clinicopathological factors influencing the detection of CTCs and CTM. These results are instructive for clinicians to understand CTCs/CTM in GIST patients. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - May 26, 2020 Category: Gastroenterology Authors: Qiang Zhang Kangjing Xu Ming Chen Yongchang Miao Nuofan Wang Zekuan Xu Hao Xu Source Type: research

Stachyose modulates gut microbiota and alleviates dextran sulfate sodium-induced acute colitis in mice
Conclusions: Our results suggested that stachyose increased beneficial microbiota and bacterial diversity to alleviate acute colitis in mice, which might be a new promising option to UC patients. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - May 26, 2020 Category: Gastroenterology Authors: Liwen He Feiran Zhang Zhengyang Jian Jiachen Sun Jiamin Chen Vuekhang Liapao Qing He Source Type: research

Inhibition of ALAS1 activity exerts anti-tumour effects on colorectal cancer in vitro
Conclusions: The abnormal expression of ALAS1 is closely related to the proliferation and metastasis of CRC cells, suggesting that ALAS1 may be a novel therapeutic target for the treatment of CRC. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - May 26, 2020 Category: Gastroenterology Authors: Yalei Zhao Xiaoyun Zhang Yabin Liu Yiping Ma Pong Kong Tianliang Bai Mei Han Binghui Li Source Type: research

Comparison of the effect of 1-day and 2-day low residue diets on the quality of bowel preparation before colonoscopy
Conclusion: LRD duration (1 day or 2 days) had no significant effect on bowel preparation quality. Patients in the 1-day LRD group had higher tolerance and satisfaction levels than patients in the 2-day LRD group. However, overall satisfaction was higher with the 1-day LRD group than with the 2-day LRD group. (Source: The Saudi Journal of Gastroenterology)
Source: The Saudi Journal of Gastroenterology - May 26, 2020 Category: Gastroenterology Authors: Li Jiao Junmin Wang Wenjuan Zhao Xinying Zhu Xia Meng Liwei Zhao Source Type: research