Biomarkers of Body Composition
Semin Musculoskelet Radiol 2024; 28: 078-091 DOI: 10.1055/s-0043-1776430The importance and impact of imaging biomarkers has been increasing over the past few decades. We review the relevant clinical and imaging terminology needed to understand the clinical and research applications of body composition. Imaging biomarkers of bone, muscle, and fat tissues obtained with dual-energy X-ray absorptiometry, computed tomography, magnetic resonance imaging, and ultrasonography are described. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents ...
Source: Seminars in Musculoskeletal Radiology - February 8, 2024 Category: Radiology Authors: Chang, Connie Y. Lenchik, Leon Blankemeier, Louis Chaudhari, Akshay S. Boutin, Robert D. Tags: Review Article Source Type: research

Bone Biomarkers Based on Magnetic Resonance Imaging
Semin Musculoskelet Radiol 2024; 28: 062-077 DOI: 10.1055/s-0043-1776431Magnetic resonance imaging (MRI) is increasingly used to evaluate the microstructural and compositional properties of bone. MRI-based biomarkers can characterize all major compartments of bone: organic, water, fat, and mineral components. However, with a short apparent spin-spin relaxation time (T2*), bone is invisible to conventional MRI sequences that use long echo times. To address this shortcoming, ultrashort echo time MRI sequences have been developed to provide direct imaging of bone and establish a set of MRI-based biomarkers sensitive to the st...
Source: Seminars in Musculoskeletal Radiology - February 8, 2024 Category: Radiology Authors: Jerban, Saeed Jang, Hyungseok Chang, Eric Y. Bukata, Susan Du, Jiang Chung, Christine B. Tags: Review Article Source Type: research

Radiomics in Musculoskeletal Tumors
Semin Musculoskelet Radiol 2024; 28: 049-061 DOI: 10.1055/s-0043-1776428Sarcomas are heterogeneous rare tumors predominantly affecting the musculoskeletal (MSK) system. Due to significant variations in their natural history and variable response to conventional treatments, the discovery of novel diagnostic and prognostic biomarkers to guide therapeutic decision-making is an active and ongoing field of research. As new cellular, molecular, and metabolic biomarkers continue to be discovered, quantitative radiologic imaging is becoming increasingly important in sarcoma management. Radiomics offers the potential for discoverin...
Source: Seminars in Musculoskeletal Radiology - February 8, 2024 Category: Radiology Authors: Brandenberger, Daniel White, Lawrence M. Tags: Review Article Source Type: research

Magnetic Resonance Imaging Biomarkers of Bone and Soft Tissue Tumors
Semin Musculoskelet Radiol 2024; 28: 039-048 DOI: 10.1055/s-0043-1776433Magnetic resonance imaging (MRI) is essential in the management of musculoskeletal (MSK) tumors. This review delves into the diverse MRI modalities, focusing on anatomical, functional, and metabolic sequences that provide essential biomarkers for tumor detection, characterization, disease extent determination, and assessment of treatment response. MRI's multimodal capabilities offer a range of biomarkers that enhance MSK tumor evaluation, aiding in better patient management. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York...
Source: Seminars in Musculoskeletal Radiology - February 8, 2024 Category: Radiology Authors: Ghasemi, Ali Ahlawat, Shivani Fayad, Laura Marie Tags: Review Article Source Type: research

Biomarkers of Cartilage Composition
Semin Musculoskelet Radiol 2024; 28: 026-038 DOI: 10.1055/s-0043-1776429Magnetic resonance imaging (MRI) has significantly advanced the understanding of osteoarthritis (OA) because it enables visualization of noncalcified tissues. Cartilage is avascular and nurtured by diffusion, so it has a very low turnover and limited capabilities of repair. Consequently, prevention of structural and detection of premorphological damage is key in maintaining cartilage health. The integrity of cartilage composition and ultrastructure determines its mechanical properties but is not accessible to morphological imaging. Therefore, various t...
Source: Seminars in Musculoskeletal Radiology - February 8, 2024 Category: Radiology Authors: L öffler, Maximilian T. Akkaya, Zehra Bhattacharjee, Rupsa Link, Thomas M. Tags: Review Article Source Type: research

Imaging Biomarkers of Osteoarthritis
This article discusses the role and potential of different imaging biomarkers in OA research. We review the current role of radiography, as well as advances in quantitative three-dimensional morphological cartilage assessment and semiquantitative whole-organ assessment of OA. Although magnetic resonance imaging has evolved as the leading imaging method in OA research, recent developments in computed tomography are also discussed briefly. Finally, we address the experience from the Foundation for the National Institutes of Health Biomarker Consortium biomarker qualification study and the future role of artificial intelligen...
Source: Seminars in Musculoskeletal Radiology - February 8, 2024 Category: Radiology Authors: Roemer, Frank W. Wirth, Wolfgang Demehri, Shadpour Kijowski, Richard Jarraya, Mohamed Hayashi, Daichi Eckstein, Felix Guermazi, Ali Tags: Review Article Source Type: research

Advancing Diagnostics and Patient Care: The Role of Biomarkers in Radiology
Semin Musculoskelet Radiol 2024; 28: 003-013 DOI: 10.1055/s-0043-1776426The integration of biomarkers into medical practice has revolutionized the field of radiology, allowing for enhanced diagnostic accuracy, personalized treatment strategies, and improved patient care outcomes. This review offers radiologists a comprehensive understanding of the diverse applications of biomarkers in medicine. By elucidating the fundamental concepts, challenges, and recent advancements in biomarker utilization, it will serve as a bridge between the disciplines of radiology and epidemiology. Through an exploration of various biomarker type...
Source: Seminars in Musculoskeletal Radiology - February 8, 2024 Category: Radiology Authors: Sebro, Ronnie Tags: Review Article Source Type: research

Biomarkers in Musculoskeletal Imaging
Semin Musculoskelet Radiol 2024; 28: 001-002 DOI: 10.1055/s-0043-1778018 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Musculoskeletal Radiology)
Source: Seminars in Musculoskeletal Radiology - February 8, 2024 Category: Radiology Authors: Kijowski, Richard Tags: Preface Source Type: research

Erratum: Value of Edema-like Marrow Signal Intensity in Diagnosis of Joint Pain: Radiologists' Perspective
Semin Musculoskelet Radiol 2023; 27: e1-e1 DOI: 10.1055/s-0043-1777083 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Musculoskeletal Radiology)
Source: Seminars in Musculoskeletal Radiology - November 16, 2023 Category: Radiology Authors: Kim, Dong Kyun Lee, Sheen-Woo Tags: Errata Source Type: research

Zygmunt Grudzi ński, 1870–1929
Semin Musculoskelet Radiol 2023; 27: 676-678 DOI: 10.1055/s-0043-1769089This history page in the series “Leaders in MSK Radiology” is dedicated to the memory and achievements of Zygmunt Grudziński, Polish radiologist at the University of Warsaw and founder of the Polish Society of Radiology and Polish Radiological Review, the first radiology journal. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Musculoskeletal Radiology)
Source: Seminars in Musculoskeletal Radiology - November 7, 2023 Category: Radiology Authors: Sudo ł-Szopińska, Iwona Panas-Goworska, Marta Szczerbo-Trojanowska, Ma łgorzata Tags: History Page Source Type: research

Up-and-coming Radiotracers for Imaging Pain Generators
This article provides an overview of promising molecular imaging approaches for the imaging of musculoskeletal pain with a focus on preclinical methods. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Seminars in Musculoskeletal Radiology)
Source: Seminars in Musculoskeletal Radiology - November 7, 2023 Category: Radiology Authors: van der Heijden, Rianne A. Biswal, Sandip Tags: Review Article Source Type: research

Radiotracers in the Diagnosis of Pain: A Mini Review
We present a mini review of the current knowledge base regarding radiotracers for identification of pain in vivo. We also describe radiocaine, a novel positron emission tomography imaging agent for sodium channels that has shown great potential for identifying/labeling pain-producing nerves and producing an objectively measurable pain intensity signal. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Musculoskeletal Radiology)
Source: Seminars in Musculoskeletal Radiology - November 7, 2023 Category: Radiology Authors: Hascalovici, Jacob Babb, Anthony Norwood, Braxton A. Tags: Review Article Source Type: research

Value of Edema-like Marrow Signal Intensity in Diagnosis of Joint Pain: Radiologists' Perspective
Semin Musculoskelet Radiol 2023; 27: 649-654 DOI: 10.1055/s-0043-1775740Musculoskeletal pain is a significant contributor to disability. The mechanism and target of the treatment should be optimized by imaging, but currently no accepted gold standard exists to image pain. In addition to end-organ pathology, other mediators also contribute to nociception, such as angiogenesis, axonal extension, immunologic modulation, and central sensitization. Recent research indicates that local inflammation is a significant contributor to pain in the extremities; therefore, we focus here on edema-like marrow signal intensity (ELMSI). We ...
Source: Seminars in Musculoskeletal Radiology - November 7, 2023 Category: Radiology Authors: Kim, Dong Kyun Lee, Sheen-Woo Tags: Review Article Source Type: research

Diffusion Tensor Imaging of Peripheral Nerves: Current Status and New Developments
Semin Musculoskelet Radiol 2023; 27: 641-648 DOI: 10.1055/s-0043-1775742Diffusion tensor imaging (DTI) is an emerging technique for peripheral nerve imaging that can provide information about the microstructural organization and connectivity of these nerves and complement the information gained from anatomical magnetic resonance imaging (MRI) sequences. With DTI it is possible to reconstruct nerve pathways and visualize the three-dimensional trajectory of nerve fibers, as in nerve tractography. More importantly, DTI allows for quantitative evaluation of peripheral nerves by the calculation of several important parameters t...
Source: Seminars in Musculoskeletal Radiology - November 7, 2023 Category: Radiology Authors: Yoon, Daehyun Lutz, Amelie M. Tags: Review Article Source Type: research

EXPLORing Arthritis with Total-body Positron Emission Tomography
This article reviews current results from using total-body PET in the assessment of common arthritic conditions, and it outlines future opportunities and challenges. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Seminars in Musculoskeletal Radiology)
Source: Seminars in Musculoskeletal Radiology - November 7, 2023 Category: Radiology Authors: Chaudhari, Abhijit J. Abdelhafez, Yasser G. Nardo, Lorenzo Raychaudhuri, Siba P. Tags: Review Article Source Type: research