Eosinophils in the pathogenesis of pancreatic disorders
AbstractEosinophils comprise approximately 1 –4% of total blood leukocytes that reside in the intestine, bone marrow, mammary gland, and adipose tissues to maintain innate immunity in healthy individuals. Eosinophils have four toxic granules known as major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase (EPO), a nd eosinophil-derived neurotoxin (EDN), and upon degranulation, these granules promote pathogenesis of inflammatory diseases like allergy, asthma, dermatitis, and gastrointestinal disorders. Additionally, the role of eosinophils is underscored in exocrine disorders including pancreat...
Source: Seminars in Immunopathology - June 1, 2021 Category: Pathology Source Type: research
The twilight zone: plasticity and mixed ontogeny of neutrophil and eosinophil granulocyte subsets
AbstractIt is now becoming clear that neutrophils and eosinophils are heterogeneous cells with potentially multiple subsets in health and disease. With greater marker coverage by multi-color flow cytometry and single-cell level sequencing of granulocyte populations, novel phenotypes of these cells began to emerge. Intriguingly, many newly described subsets blend distinctions between classical myeloid lineage phenotypes, which are especially true for tissue resident or recruited cells in contexts of inflammation and disease. This includes reports of neutrophils with features of eosinophils, monocytes and dendritic cells, an...
Source: Seminars in Immunopathology - June 1, 2021 Category: Pathology Source Type: research
Eosinophilic esophagitis —established facts and new horizons
AbstractDespite dramatic advances in our understanding of the pathogenesis and course of disease in the relatively short timeframe since the discovery and first description of eosinophilic esophagitis (EoE) less than three decades ago, many open questions remain to be elucidated. For instance, we will need to better characterize atypical clinical presentations of EoE and other forms of esophageal inflammatory conditions with often similar clinical presentations, nut fulfilling current diagnostic criteria for EoE and to determine their significance and interrelationship with genuine EoE. In addition, the interrelationship o...
Source: Seminars in Immunopathology - June 1, 2021 Category: Pathology Source Type: research
Eosinophils and COVID-19: diagnosis, prognosis, and vaccination strategies
AbstractThe unprecedented impact of the coronavirus disease 2019 (COVID-19) pandemic has resulted in global challenges to our health-care systems and our economic security. As such, there has been significant research into all aspects of the disease, including diagnostic biomarkers, associated risk factors, and strategies that might be used for its treatment and prevention. Toward this end, eosinopenia has been identified as one of many factors that might facilitate the diagnosis and prognosis of severe COVID-19. However, this finding is neither definitive nor pathognomonic for COVID-19. While eosinophil-associated conditi...
Source: Seminars in Immunopathology - June 1, 2021 Category: Pathology Source Type: research
The eosinophil and its role in physiology and disease: news and views
(Source: Seminars in Immunopathology)
Source: Seminars in Immunopathology - June 1, 2021 Category: Pathology Source Type: research
