Tissue-resident memory T cells in the kidney
AbstractThe identification of tissue-resident memory T cells (TRM cells) has significantly improved our understanding of immunity. In the last decade, studies have demonstrated that TRM cells are induced after an acute T-cell response, remain in peripheral organs for several years, and contribute to both an efficient host defense and autoimmune disease. TRM cells are found in the kidneys of healthy individuals and patients with various kidney diseases. A better understanding of these cells and their therapeutic targeting might provide new treatment options for infections, autoimmune diseases, graft rejection, and cancer. I...
Source: Seminars in Immunopathology - April 11, 2022 Category: Pathology Source Type: research
T-cell surveillance of the human brain in health and multiple sclerosis
AbstractCirculating and tissue-resident T cells collaborate in the protection of tissues against harmful infections and malignant transformation but also can instigate autoimmune reactions. Similar roles for T cells in the brain have been less evident due to the compartmentized organization of the central nervous system (CNS). In recent years, beneficial as well as occasional, detrimental effects of T-cell-targeting drugs in people with early multiple sclerosis (MS) have increased interest in T cells patrolling the CNS. Next to studies focusing on T cells in the cerebrospinal fluid, phenotypic characteristics of T cells lo...
Source: Seminars in Immunopathology - April 1, 2022 Category: Pathology Source Type: research
Correction to: Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target
(Source: Seminars in Immunopathology)
Source: Seminars in Immunopathology - March 31, 2022 Category: Pathology Source Type: research
Cardiovascular disease risk and pathogenesis in systemic lupus erythematosus
AbstractSystemic lupus erythematosus (SLE) often features extensive cardiovascular (CV) comorbidity and patients with SLE are at significantly increased risk of CV event occurrence and CV-related mortality. While the specific mechanisms leading to this increased cardiovascular disease (CVD) risk remain to be fully characterized, this heightened risk cannot be fully explained by traditional CV risk factors and is likely driven by immunologic and inflammatory features of SLE. Widespread innate and adaptive immune dysregulation characterize SLE, and factors including excessive type I interferon burden, inappropriate formation...
Source: Seminars in Immunopathology - March 30, 2022 Category: Pathology Source Type: research
Correction to: Complement in ischaemia –reperfusion injury and transplantation
(Source: Seminars in Immunopathology)
Source: Seminars in Immunopathology - March 18, 2022 Category: Pathology Source Type: research
Mechanisms of vascular damage in ANCA vasculitis
Abstract
The discovery of anti-neutrophil cytoplasmic antibodies (ANCA) and their antigenic targets, myeloperoxidase (MPO) and proteinase 3 (PR3), has led to further understanding as to the pathophysiologic processes that underlie vascular and tissue damage in ANCA vasculitis. ANCA trigger neutrophil activation leading to vascular damage in ANCA vasculitis. However, decades of study have determined that neutrophil activation alone is not sufficient to cause disease. Inflammatory stimuli are drivers of ANCA autoantigen expression and ANCA production. Certain infections or bacterial peptides may be crucial players in the ...
Source: Seminars in Immunopathology - March 7, 2022 Category: Pathology Source Type: research
Atherosclerosis and multi-organ-associated pathologies
AbstractAtherosclerosis is a chronic inflammatory disease of the vascular system that is characterized by the deposition of modified lipoproteins, accumulation of immune cells, and formation of fibrous tissue within the vessel wall. The disease occurs in vessels throughout the body and affects the functions of almost all organs including the lymphoid system, bone marrow, heart, brain, pancreas, adipose tissue, liver, kidneys, and gastrointestinal tract. Atherosclerosis and associated factors influence these tissues via the modulation of local vascular functions, induction of cholesterol-associated pathologies, and regulati...
Source: Seminars in Immunopathology - March 3, 2022 Category: Pathology Source Type: research
Chronoimmunology: from preclinical assessments to clinical applications
(Source: Seminars in Immunopathology)
Source: Seminars in Immunopathology - March 1, 2022 Category: Pathology Source Type: research
