Rheumatic Disease Clinics of North America This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Targeting Nerve Growth Factor for Pain Management in Osteoarthritis —Clinical Efficacy and Safety
Nerve growth factor (NGF) is a neurotrophin that mediates pain sensitization in pathologic states, including osteoarthritis. In clinical trials, antibodies to NGF reduce pain and improve physical function due to osteoarthritis of the knee or hip and have a long duration of action. Rapidly progressive osteoarthritis is a dose-dependent adverse event with these agents, and additional joint safety signals, such as subchondral insufficiency fractures and increased rates of total joint replacement, are reported. The effects on pain and potential mechanisms behind these joint events both are of considerable importance in the con...
Source: Rheumatic Disease Clinics of North America - March 12, 2021 Category: Rheumatology Authors: Brett W. Dietz, Mary C. Nakamura, Matthew T. Bell, Nancy E. Lane Source Type: research

Cannabinoids and Pain
This article seeks to summarize clinically relevant findings in cannabinoid research to better prepare clinicians in the utility of cannabis in the treatment of pain. (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - February 27, 2021 Category: Rheumatology Authors: Oliver Hulland, Jessica Oswald Source Type: research

Pain in Axial Spondyloarthritis
Inflammatory back pain is characteristic of spondyloarthritis (SpA); however, this pain may not respond to treatment with NSAIDs or biologics. Pain is multifactorial and a combination of mechanical and inflammatory factors. A growing body of literature examines the impact of emotions on pain in SpA; many patients with this condition suffer from depression and fibromyalgia. Advanced imaging techniques can investigate the interplay of various brain networks in pain perception. Animal models have helped understand the interplay between the immune and nervous systems in pain generation and have highlighted differences in pain ...
Source: Rheumatic Disease Clinics of North America - February 27, 2021 Category: Rheumatology Authors: Ejaz M.I. Pathan, Robert D. Inman Source Type: research

Why It Hurts
Pain is a near-universal feature of rheumatoid arthritis, but peripheral joint inflammation may not suffice to explain the etiology of pain in all patients with rheumatoid arthritis. Inflammation in rheumatoid arthritis releases several algogens that may generate pain. Also, central nervous system processes may play a crucial role in the regulation and perpetuation of pain. Several methods for assessing pain in rheumatoid arthritis exist, and recently the role of assessing therapeutics in treating specific etiologies of pain has gained interest. (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - February 27, 2021 Category: Rheumatology Authors: Priyanka Iyer, Yvonne C. Lee Source Type: research

Sexual Dimorphism in the Expression of Pain Phenotype in Preclinical Models of Rheumatoid Arthritis
Rheumatoid arthritis is one of most frequent rheumatic diseases, affecting around 1% of the population worldwide. Pain impacting the quality of life for the patient with rheumatoid arthritis, is often the primary factor leading them to seek medical care. Although sex-related differences in humans and animal models of rheumatoid arthritis are described, the correlation between pain and sex in rheumatoid arthritis has only recently been directly examined. Here we review the literature and explore the mechanisms underlying the expression of the pain phenotype in females and males in preclinical models of rheumatoid arthritis....
Source: Rheumatic Disease Clinics of North America - February 26, 2021 Category: Rheumatology Authors: Lauriane Delay, Gilson Gon çalves dos Santos, Elayne Vieira Dias, Tony L. Yaksh, Maripat Corr Source Type: research

Nonpharmacologic Pain Management in Inflammatory Arthritis
This article provides an overview of nonpharmacologic options for the treatment of pain in patients with inflammatory arthritis, such as peripheral spondyloarthritis, psoriatic arthritis, ankylosing spondylitis, and rheumatoid arthritis. The experience of pain in chronic disease is a complex process influenced by multiple domains of health. The discussion focuses on the establishment of a framework for pain control that engages with factors that influence the experience of pain and explores the evidence base that supports specific modalities of nonpharmacologic pain control, such as mindfulness, cognitive behavioral therap...
Source: Rheumatic Disease Clinics of North America - February 26, 2021 Category: Rheumatology Authors: Alexander Martin, Ratnesh Chopra, Perry M. Nicassio Source Type: research

Pain Mechanisms in Patients with Rheumatic Diseases
Patients with rheumatic diseases often have mixed pain states, with varying degrees of nociceptive, neuropathic, and nociplastic mechanisms, which exist on a continuum. When individuals with any chronic pain have a nociplastic component to their symptoms, they are less likely to respond to treatments (eg, injections, surgery, biologics, and opioids) that work better for acute or purely nociceptive pain. (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - February 26, 2021 Category: Rheumatology Authors: Deeba Minhas, Daniel Joseph Clauw Source Type: research

The Categorization of Pain in Systemic Lupus Erythematosus
Systemic lupus erythematous is a systemic autoimmune disease that can cause severe pain and impair quality of life. Pain in lupus can arise from a variety of mechanisms and is usually assessed in terms of activity and damage. In contrast, categorization of symptoms as type 1 and type 2 manifestations encompasses a broader array of symptoms, including widespread pain, fatigue, and depression that may track together. The categorization of symptoms as type 1 and type 2 manifestations can facilitate communication between patient and provider as well as provide a framework to address more fully the complex symptoms experienced ...
Source: Rheumatic Disease Clinics of North America - February 25, 2021 Category: Rheumatology Authors: David S. Pisetsky, Amanda M. Eudy, Megan E.B. Clowse, Jennifer L. Rogers Source Type: research

Pain in Rheumatic Diseases
The 5 classic signs of inflammation include redness (Latin rubor), pain (dolor), heat (calor), swelling (tumor), and loss of function. Hence, it is not surprising that pain would be a frequent concern of patients with rheumatic diseases. The mechanisms associated with pain perception are complex and involve both central and peripheral processes associated with nociception coupled with responses to individualized experiences, such as sleep disturbances, psychosocial stresses, and past circumstances. (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - February 25, 2021 Category: Rheumatology Authors: Maripat Corr Tags: Preface Source Type: research

Pain in Rheumatic Diseases
Dr Maripat Corr has put together a remarkable “theme” issue about pain, a real tour de force! Since pain is what distinguishes our patients from almost all other disciplines and specialties and in most cases also drives our clinical and therapeutic decisions, we appreciate the opportunity to receive this information in order to understand t he complex nature of pain in rheumatic diseases. The conditions we deal with are also challenging since even in a single patient there may be more than one pain mechanism or experience. (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - February 25, 2021 Category: Rheumatology Authors: Michael H. Weisman Tags: Foreword Source Type: research

Community-Engaged Research: Leveraging Community-Academic Partnerships to Reduce Disparities and Inequities in Lupus Care
Community-engaged research is an effective tool to address health care disparities and inequities in lupus care. Community-based participatory research allows the highest degree of community engagement, but may be limited by the challenges associated with long-term funding and implementation. Community-academic partnerships are a feasible way to allow for varying degrees of community engagement and develop sustainable infrastructure. Two examples of community-engaged research in rheumatology are MONARCAS and Lupus Conversations. (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - November 14, 2020 Category: Rheumatology Authors: Cianna Leatherwood, Patricia Canessa, Karen Cuevas, Elmer Freeman, Candace H. Feldman, Rosalind Ramsey-Goldman Source Type: research

Leveraging Telemedicine as an Approach to Address Rheumatic Disease Health Disparities
Telerheumatology is the application of telehealth to rheumatic disease. Although generally acceptable to both providers and patients, little is known about the safety of telerheumatology or about when, how, and for whom it is best used. Telerheumatology ’s impact on the rheumatology workforce as well as access to care and health disparities in rheumatic disease is not known. These outcomes likely will depend on the specific telemedicine modalities employed. (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - November 14, 2020 Category: Rheumatology Authors: John McDougall Source Type: research

Health Disparities in Rheumatic Diseases
Rheumatic diseases reach across continents with some similarities as well as unique challenges. The intersection between genetic factors, environmental exposures and socioeconomic factors, as well as challenges, with delays in access to subspecialty care and medications, manifest in different ways. By understanding both the challenges and successes in different countries, while also recognizing the significant diversity both within and across continents, unified strategies to improve rheumatic disease outcomes and decrease disparities among the most vulnerable groups can be developed and disseminated. (Source: Rheumatic Di...
Source: Rheumatic Disease Clinics of North America - November 14, 2020 Category: Rheumatology Authors: Dzifa Dey, Savino Sciascia, Guillermo J. Pons-Estel, Huihua Ding, Nan Shen Source Type: research

Health Disparities in Rheumatic Diseases - Issue 2
Right now, our society is confronted with the ramifications of a global pandemic and of longstanding inequities by race, ethnicity, and socioeconomic status. The two are closely intertwined, and both require urgent attention and action. In this second issue on Health Disparities in Rheumatic Disease Clinics of North America, the authors explore the underpinnings of the racial, ethnic, and socioeconomic disparities observed in rheumatic disease burden and outcomes and propose strategies to promote health equity. (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - November 14, 2020 Category: Rheumatology Authors: Candace H. Feldman Tags: Preface Source Type: research

Health Disparities in Rheumatic Diseases: Part II
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - November 14, 2020 Category: Rheumatology Authors: Candace H. Feldman Source Type: research