Rheumatic Disease Clinics of North America This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Management of Pregnancy in Lupus
Systemic lupus erythematosus (SLE) is an autoimmune disease that primarily affects women of childbearing age. Pregnancy-related morbidity and mortality are well described in SLE; however, better management of disease activity throughout the disease course have minimized periods of disease activity and damage accrual, making pregnancy more feasible and desirable. A growing body of literature has defined risk factors for adverse pregnancy outcomes in patients with SLE, and coordinated medical and obstetric management has allowed most patients with SLE to safely achieve full-term pregnancies by timing pregnancy to maximal dis...
Source: Rheumatic Disease Clinics of North America - June 15, 2021 Category: Rheumatology Authors: Amanda Moyer, Eliza F. Chakravarty Source Type: research

Innovative Trials and New Opportunities in SLE
Despite progress in the treatment of systemic lupus erythematosus (SLE), remission rates and health-related quality of life remain disappointingly low. The paucity of successful SLE clinical trials reminds us that we still have a long way to go. Nevertheless, there are clear signs of hope. We highlight results from recent studies of novel therapeutic strategies based on emerging insights into our understanding of SLE disease mechanisms. We also highlight several studies that inform optimal use of existing treatments to improve efficacy and/or limit toxicity. These developments suggest we may yet unlock the key toward more ...
Source: Rheumatic Disease Clinics of North America - June 15, 2021 Category: Rheumatology Authors: Yashaar Chaichian, Daniel J. Wallace Source Type: research

Interferons in Systemic Lupus Erythematosus
Skewing of type I interferon (IFN) production and responses is a hallmark of systemic lupus erythematosus (SLE). Genetic and environmental contributions to IFN production lead to aberrant innate and adaptive immune activation even before clinical development of disease. Basic and translational research in this arena continues to identify contributions of IFNs to disease pathogenesis, and several promising therapeutic options for targeting of type I IFNs and their signaling pathways are in development for treatment of SLE patients. (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - June 10, 2021 Category: Rheumatology Authors: Sirisha Sirobhushanam, Stephanie Lazar, J. Michelle Kahlenberg Source Type: research

Systemic Lupus Erythematosus Outcome Measures for Systemic Lupus Erythematosus Clinical Trials
The assessment of systemic lupus erythematosus (SLE) disease activity in clinical trials has been challenging. This is related to the wide spectrum of SLE manifestations and the heterogeneity of the disease trajectory. Currently, composite outcome measures are most commonly used as a primary endpoint while organ-specific measures are often used as secondary outcomes. In this article, we review the outcome measures and endpoints used in most recent clinical trials and explore potential avenues for further development of new measures and the refinement of existing tools. (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - June 10, 2021 Category: Rheumatology Authors: Taraneh Tofighi, Eric Morand, Zahi Touma Source Type: research

Lupus Cohorts
Large cohorts with diverse ethnic backgrounds and heterogenous clinical features have provided the real-life data about the safety and efficacy of various treatment regimens for systemic lupus erythematosus (SLE). There are multiple well-established regional, national, and international lupus cohorts that have made significant contributions to the understanding of SLE. Using social media for cohort-based studies can significantly increase the outreach in a short time period for studying rare diseases such as SLE. Lack of strict inclusion criteria allows study of a broad range of patients but selection bias and incomplete d...
Source: Rheumatic Disease Clinics of North America - June 10, 2021 Category: Rheumatology Authors: Christopher Redmond, Omer Pamuk, Sarfaraz A. Hasni Source Type: research

Systemic Lupus Erythematosus Classification and Diagnosis
Since the European League Against Rheumatism/American College of Rheumatology 2019 classification criteria for systemic lupus erythematosus (SLE) were published, they were externally validated by groups worldwide. In particular, the new criteria worked well also in East Asian and pediatric cohorts. Antinuclear antibodies (ANA) as an entry criterion were critically discussed, but the group of ANA-negative patients is small ( (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - June 10, 2021 Category: Rheumatology Authors: Martin Aringer, Sindhu R. Johnson Source Type: research

Treatment Update in Systemic Lupus Erythematous
The recent updates on treatment recommendations for the management of systemic lupus erythematous have provided greater clarity in the way existing anti-inflammatory and immunomodulatory drugs are used, in treating disease activity, preventing flares, and reducing irreversible organ damage and toxicity arising from the treatments themselves. Novel therapies will provide more options in the armamentarium for treating this complex disease, but ongoing studies are needed to improve understanding of the optimal treatment algorithm to maintain quality of life and improve survival for patients. (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - June 10, 2021 Category: Rheumatology Authors: Alberta Y. Hoi, Eric F. Morand Source Type: research

Neutrophil Dysregulation in the Pathogenesis of Systemic Lupus Erythematosus
This article presents an overview on how neutrophil dysregulation modulates the innate and adaptive immune responses in SLE and their putative roles in disease pathogenesis. The therapeutic potential of targeting this pathogenic process in the treatment of SLE is also discussed. (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - June 9, 2021 Category: Rheumatology Authors: Yudong Liu, Mariana J. Kaplan Source Type: research

Basic Mechanisms of Pain in Osteoarthritis
The specific changes in the peripheral neuronal pathways underlying joint pain in osteoarthritis are the focus of this review. The plasticity of the nociceptive system in osteoarthritis and how this involves changes in the structural, physiologic, and genetic properties of neurons in pain pathways are discussed. The role of the neurotrophin, nerve growth factor, in these pathogenic processes is discussed. Finally, how neuronal pathways are modified by interaction with the degenerating joint tissues they innervate and with the innate immune system is considered. These extensive cellular interactions provide a substrate for ...
Source: Rheumatic Disease Clinics of North America - March 27, 2021 Category: Rheumatology Authors: Anne-Marie Malfait, Rachel E. Miller, Richard J. Miller Source Type: research

Pain in Rheumatic Diseases
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - March 27, 2021 Category: Rheumatology Authors: Maripat Corr Source Type: research

Copyright
ELSEVIER (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - March 27, 2021 Category: Rheumatology Source Type: research

Contributors
MICHAEL H. WEISMAN, MD (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - March 27, 2021 Category: Rheumatology Source Type: research

Contents
Michael H. Weisman (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - March 27, 2021 Category: Rheumatology Source Type: research

Rheumatic Disease Clinics of North America
Lupus (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - March 27, 2021 Category: Rheumatology Source Type: research

Low Back Pain in Adolescent and Geriatric Populations
Spinal pain is the most common form of musculoskeletal pain. Chronic low back pain may contain nociceptive, neuropathic, and central components. Children are at risk of developing spinal pain. An increasing proportion of children develop low back pain as they become adolescents. In most adolescents, no specific diagnosis is identified. Psychological factors play a role in adolescents with back pain. Lumbar spinal stenosis causes neurogenic claudication in older patients. Magnetic resonance imaging is the best radiographic technique to detect nerve compression. Surgical decompression with or without fusion may offer greater...
Source: Rheumatic Disease Clinics of North America - March 12, 2021 Category: Rheumatology Authors: David G. Borenstein, Federico Balagu é Source Type: research