The metabolism of melanin synthesis-From melanocytes to melanoma
In this report we provide an updated review on melanin metabolism, including recent data leveraging new techniques, and technologies in the field of metabolism. We also discuss the many aspects of melanin synthesis that intersect with metabolic pathways known to impact melanoma phenotypes and behavior. By reviewing the metabolism of melanin synthesis, we hope to highlight outstanding questions and opportunities for future research that could improve patient outcomes in pigmentary and oncologic disease settings.PMID:38445351 | DOI:10.1111/pcmr.13165 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - March 6, 2024 Category: Cytology Authors: Marelize Snyman Rachel Elizabeth Walsdorf Sophia Nicole Wix Jennifer Gibson Gill Source Type: research
The metabolism of melanin synthesis-From melanocytes to melanoma
In this report we provide an updated review on melanin metabolism, including recent data leveraging new techniques, and technologies in the field of metabolism. We also discuss the many aspects of melanin synthesis that intersect with metabolic pathways known to impact melanoma phenotypes and behavior. By reviewing the metabolism of melanin synthesis, we hope to highlight outstanding questions and opportunities for future research that could improve patient outcomes in pigmentary and oncologic disease settings.PMID:38445351 | DOI:10.1111/pcmr.13165 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - March 6, 2024 Category: Cytology Authors: Marelize Snyman Rachel Elizabeth Walsdorf Sophia Nicole Wix Jennifer Gibson Gill Source Type: research
The metabolism of melanin synthesis-From melanocytes to melanoma
In this report we provide an updated review on melanin metabolism, including recent data leveraging new techniques, and technologies in the field of metabolism. We also discuss the many aspects of melanin synthesis that intersect with metabolic pathways known to impact melanoma phenotypes and behavior. By reviewing the metabolism of melanin synthesis, we hope to highlight outstanding questions and opportunities for future research that could improve patient outcomes in pigmentary and oncologic disease settings.PMID:38445351 | DOI:10.1111/pcmr.13165 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - March 6, 2024 Category: Cytology Authors: Marelize Snyman Rachel Elizabeth Walsdorf Sophia Nicole Wix Jennifer Gibson Gill Source Type: research
The metabolism of melanin synthesis-From melanocytes to melanoma
In this report we provide an updated review on melanin metabolism, including recent data leveraging new techniques, and technologies in the field of metabolism. We also discuss the many aspects of melanin synthesis that intersect with metabolic pathways known to impact melanoma phenotypes and behavior. By reviewing the metabolism of melanin synthesis, we hope to highlight outstanding questions and opportunities for future research that could improve patient outcomes in pigmentary and oncologic disease settings.PMID:38445351 | DOI:10.1111/pcmr.13165 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - March 6, 2024 Category: Cytology Authors: Marelize Snyman Rachel Elizabeth Walsdorf Sophia Nicole Wix Jennifer Gibson Gill Source Type: research
The metabolism of melanin synthesis-From melanocytes to melanoma
In this report we provide an updated review on melanin metabolism, including recent data leveraging new techniques, and technologies in the field of metabolism. We also discuss the many aspects of melanin synthesis that intersect with metabolic pathways known to impact melanoma phenotypes and behavior. By reviewing the metabolism of melanin synthesis, we hope to highlight outstanding questions and opportunities for future research that could improve patient outcomes in pigmentary and oncologic disease settings.PMID:38445351 | DOI:10.1111/pcmr.13165 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - March 6, 2024 Category: Cytology Authors: Marelize Snyman Rachel Elizabeth Walsdorf Sophia Nicole Wix Jennifer Gibson Gill Source Type: research
The metabolism of melanin synthesis-From melanocytes to melanoma
In this report we provide an updated review on melanin metabolism, including recent data leveraging new techniques, and technologies in the field of metabolism. We also discuss the many aspects of melanin synthesis that intersect with metabolic pathways known to impact melanoma phenotypes and behavior. By reviewing the metabolism of melanin synthesis, we hope to highlight outstanding questions and opportunities for future research that could improve patient outcomes in pigmentary and oncologic disease settings.PMID:38445351 | DOI:10.1111/pcmr.13165 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - March 6, 2024 Category: Cytology Authors: Marelize Snyman Rachel Elizabeth Walsdorf Sophia Nicole Wix Jennifer Gibson Gill Source Type: research
The metabolism of melanin synthesis-From melanocytes to melanoma
In this report we provide an updated review on melanin metabolism, including recent data leveraging new techniques, and technologies in the field of metabolism. We also discuss the many aspects of melanin synthesis that intersect with metabolic pathways known to impact melanoma phenotypes and behavior. By reviewing the metabolism of melanin synthesis, we hope to highlight outstanding questions and opportunities for future research that could improve patient outcomes in pigmentary and oncologic disease settings.PMID:38445351 | DOI:10.1111/pcmr.13165 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - March 6, 2024 Category: Cytology Authors: Marelize Snyman Rachel Elizabeth Walsdorf Sophia Nicole Wix Jennifer Gibson Gill Source Type: research
Topical antibiotics limit depigmentation in a mouse model of vitiligo
Pigment Cell Melanoma Res. 2024 Mar 4. doi: 10.1111/pcmr.13164. Online ahead of print.ABSTRACTOral neomycin administration impacts the gut microbiome and delays vitiligo development in mice, and topical antibiotics may likewise allow the microbiome to preserve skin health and delay depigmentation. Here, we examined the effects of 6-week topical antibiotic treatment on vitiligo-prone pmel-1 mice. Bacitracin, Neosporin, or Vaseline were applied to one denuded flank, while the contralateral flank was treated with Vaseline in all mice. Ventral depigmentation was quantified weekly. We found that topical Neosporin treatment sign...
Source: Pigment Cell and Melanoma Research - March 5, 2024 Category: Cytology Authors: Ahmed Ahmed Touni Rachel Sohn Cormac Cosgrove Rohan S Shivde Emilia R Dellacecca Rasha T A Abdel-Aziz Kettil Cedercreutz Stefan J Green Hossam Abdel-Wahab I Caroline Le Poole Source Type: research
Genetic insights into Tietz albinism-deafness syndrome: A new dominant-negative mutation in MITF
This study sheds light on the genetic mechanisms underlying TADS and offers a deeper understanding of this rare condition and its associated mutations in MITF.PMID:38439523 | DOI:10.1111/pcmr.13166 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - March 5, 2024 Category: Cytology Authors: Kohei Yamamoto Ken Okamura Kazumasa Wakamatsu Shosuke Ito Kozue Akabane Yosuke Arai Junnosuke Kawaguchi Yutaka Hozumi Tamio Suzuki Source Type: research
Topical antibiotics limit depigmentation in a mouse model of vitiligo
Pigment Cell Melanoma Res. 2024 Mar 4. doi: 10.1111/pcmr.13164. Online ahead of print.ABSTRACTOral neomycin administration impacts the gut microbiome and delays vitiligo development in mice, and topical antibiotics may likewise allow the microbiome to preserve skin health and delay depigmentation. Here, we examined the effects of 6-week topical antibiotic treatment on vitiligo-prone pmel-1 mice. Bacitracin, Neosporin, or Vaseline were applied to one denuded flank, while the contralateral flank was treated with Vaseline in all mice. Ventral depigmentation was quantified weekly. We found that topical Neosporin treatment sign...
Source: Pigment Cell and Melanoma Research - March 5, 2024 Category: Cytology Authors: Ahmed Ahmed Touni Rachel Sohn Cormac Cosgrove Rohan S Shivde Emilia R Dellacecca Rasha T A Abdel-Aziz Kettil Cedercreutz Stefan J Green Hossam Abdel-Wahab I Caroline Le Poole Source Type: research
Genetic insights into Tietz albinism-deafness syndrome: A new dominant-negative mutation in MITF
This study sheds light on the genetic mechanisms underlying TADS and offers a deeper understanding of this rare condition and its associated mutations in MITF.PMID:38439523 | DOI:10.1111/pcmr.13166 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - March 5, 2024 Category: Cytology Authors: Kohei Yamamoto Ken Okamura Kazumasa Wakamatsu Shosuke Ito Kozue Akabane Yosuke Arai Junnosuke Kawaguchi Yutaka Hozumi Tamio Suzuki Source Type: research
Emerging therapeutic strategies for metastatic uveal melanoma: Targeting driver mutations
Pigment Cell Melanoma Res. 2024 Feb 27. doi: 10.1111/pcmr.13161. Online ahead of print.ABSTRACTUveal melanoma (UM) is the most common primary malignant intraocular tumor in adults. Although primary UM can be effectively controlled, a significant proportion of cases (40% or more) eventually develop distant metastases, commonly in the liver. Metastatic UM remains a lethal disease with limited treatment options. The initiation of UM is typically attributed to activating mutations in GNAQ or GNA11. The elucidation of the downstream pathways such as PKC/MAPK, PI3K/AKT/mTOR, and Hippo-YAP have provided potential therapeutic targ...
Source: Pigment Cell and Melanoma Research - February 27, 2024 Category: Cytology Authors: Xiao-Lian Liu Zhou Run-Hua Jing-Xuan Pan Zhi-Jie Li Le Yu Yi-Lei Li Source Type: research
Emerging therapeutic strategies for metastatic uveal melanoma: Targeting driver mutations
Pigment Cell Melanoma Res. 2024 Feb 27. doi: 10.1111/pcmr.13161. Online ahead of print.ABSTRACTUveal melanoma (UM) is the most common primary malignant intraocular tumor in adults. Although primary UM can be effectively controlled, a significant proportion of cases (40% or more) eventually develop distant metastases, commonly in the liver. Metastatic UM remains a lethal disease with limited treatment options. The initiation of UM is typically attributed to activating mutations in GNAQ or GNA11. The elucidation of the downstream pathways such as PKC/MAPK, PI3K/AKT/mTOR, and Hippo-YAP have provided potential therapeutic targ...
Source: Pigment Cell and Melanoma Research - February 27, 2024 Category: Cytology Authors: Xiao-Lian Liu Zhou Run-Hua Jing-Xuan Pan Zhi-Jie Li Le Yu Yi-Lei Li Source Type: research
Emerging therapeutic strategies for metastatic uveal melanoma: Targeting driver mutations
Pigment Cell Melanoma Res. 2024 Feb 27. doi: 10.1111/pcmr.13161. Online ahead of print.ABSTRACTUveal melanoma (UM) is the most common primary malignant intraocular tumor in adults. Although primary UM can be effectively controlled, a significant proportion of cases (40% or more) eventually develop distant metastases, commonly in the liver. Metastatic UM remains a lethal disease with limited treatment options. The initiation of UM is typically attributed to activating mutations in GNAQ or GNA11. The elucidation of the downstream pathways such as PKC/MAPK, PI3K/AKT/mTOR, and Hippo-YAP have provided potential therapeutic targ...
Source: Pigment Cell and Melanoma Research - February 27, 2024 Category: Cytology Authors: Xiao-Lian Liu Zhou Run-Hua Jing-Xuan Pan Zhi-Jie Li Le Yu Yi-Lei Li Source Type: research
Emerging therapeutic strategies for metastatic uveal melanoma: Targeting driver mutations
Pigment Cell Melanoma Res. 2024 Feb 27. doi: 10.1111/pcmr.13161. Online ahead of print.ABSTRACTUveal melanoma (UM) is the most common primary malignant intraocular tumor in adults. Although primary UM can be effectively controlled, a significant proportion of cases (40% or more) eventually develop distant metastases, commonly in the liver. Metastatic UM remains a lethal disease with limited treatment options. The initiation of UM is typically attributed to activating mutations in GNAQ or GNA11. The elucidation of the downstream pathways such as PKC/MAPK, PI3K/AKT/mTOR, and Hippo-YAP have provided potential therapeutic targ...
Source: Pigment Cell and Melanoma Research - February 27, 2024 Category: Cytology Authors: Xiao-Lian Liu Zhou Run-Hua Jing-Xuan Pan Zhi-Jie Li Le Yu Yi-Lei Li Source Type: research
