Myron Gordon Award Lecture 2023: Painting the neural crest: How studying pigment cells illuminates neural crest cell biology
Pigment Cell Melanoma Res. 2023 Nov 27. doi: 10.1111/pcmr.13147. Online ahead of print.ABSTRACTIt has been 30 (!!) years since I began working on zebrafish pigment cells, as a postdoc in the laboratory of Prof. Christiane Nüsslein-Volhard. There, I participated in the first large-scale mutagenesis screen in zebrafish, focusing on pigment cell mutant phenotypes. The isolation of colourless, shady, parade and choker mutants allowed us (as a postdoc in Prof. Judith Eisen's laboratory, and then in my own laboratory at the University of Bath since 1997) to pursue my ambition to address long-standing problems in the neural cres...
Source: Pigment Cell and Melanoma Research - November 27, 2023 Category: Cytology Authors: Robert N Kelsh Source Type: research
MitoCur-1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14
In this study, we have demonstrated that it can work as a novel USP14 inhibitor, and thus bears great potential in providing an anti-tumor effect and sensitizing vem-resistant cells by inducing ferroptosis in melanoma. Application of MitoCur-1 dramatically induces USP14 inhibition and inactivation of GPX4 enzyme, meanwhile, increases the depletion of GSH and decreases SLC7A11 expression level. As a result, ferrous iron-dependent lipid ROS accumulated in the cell, inducing ferroptosis, thus sensitizes the vem-resistant melanoma cell. Interestingly, overexpression of USP14 antagonized all the ferroptosis cascade events induc...
Source: Pigment Cell and Melanoma Research - November 20, 2023 Category: Cytology Authors: Gege Li Changlong Zhou Lu Wang Yalong Zheng Bo Zhou Guoyan Li Zhongyu Ma Peng Sun Yuantao Deng Li Su Junling Wang Hongmei Cui Source Type: research
MitoCur-1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14
In this study, we have demonstrated that it can work as a novel USP14 inhibitor, and thus bears great potential in providing an anti-tumor effect and sensitizing vem-resistant cells by inducing ferroptosis in melanoma. Application of MitoCur-1 dramatically induces USP14 inhibition and inactivation of GPX4 enzyme, meanwhile, increases the depletion of GSH and decreases SLC7A11 expression level. As a result, ferrous iron-dependent lipid ROS accumulated in the cell, inducing ferroptosis, thus sensitizes the vem-resistant melanoma cell. Interestingly, overexpression of USP14 antagonized all the ferroptosis cascade events induc...
Source: Pigment Cell and Melanoma Research - November 20, 2023 Category: Cytology Authors: Gege Li Changlong Zhou Lu Wang Yalong Zheng Bo Zhou Guoyan Li Zhongyu Ma Peng Sun Yuantao Deng Li Su Junling Wang Hongmei Cui Source Type: research
MitoCur-1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14
In this study, we have demonstrated that it can work as a novel USP14 inhibitor, and thus bears great potential in providing an anti-tumor effect and sensitizing vem-resistant cells by inducing ferroptosis in melanoma. Application of MitoCur-1 dramatically induces USP14 inhibition and inactivation of GPX4 enzyme, meanwhile, increases the depletion of GSH and decreases SLC7A11 expression level. As a result, ferrous iron-dependent lipid ROS accumulated in the cell, inducing ferroptosis, thus sensitizes the vem-resistant melanoma cell. Interestingly, overexpression of USP14 antagonized all the ferroptosis cascade events induc...
Source: Pigment Cell and Melanoma Research - November 20, 2023 Category: Cytology Authors: Gege Li Changlong Zhou Lu Wang Yalong Zheng Bo Zhou Guoyan Li Zhongyu Ma Peng Sun Yuantao Deng Li Su Junling Wang Hongmei Cui Source Type: research
MitoCur-1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14
In this study, we have demonstrated that it can work as a novel USP14 inhibitor, and thus bears great potential in providing an anti-tumor effect and sensitizing vem-resistant cells by inducing ferroptosis in melanoma. Application of MitoCur-1 dramatically induces USP14 inhibition and inactivation of GPX4 enzyme, meanwhile, increases the depletion of GSH and decreases SLC7A11 expression level. As a result, ferrous iron-dependent lipid ROS accumulated in the cell, inducing ferroptosis, thus sensitizes the vem-resistant melanoma cell. Interestingly, overexpression of USP14 antagonized all the ferroptosis cascade events induc...
Source: Pigment Cell and Melanoma Research - November 20, 2023 Category: Cytology Authors: Gege Li Changlong Zhou Lu Wang Yalong Zheng Bo Zhou Guoyan Li Zhongyu Ma Peng Sun Yuantao Deng Li Su Junling Wang Hongmei Cui Source Type: research
MitoCur-1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14
In this study, we have demonstrated that it can work as a novel USP14 inhibitor, and thus bears great potential in providing an anti-tumor effect and sensitizing vem-resistant cells by inducing ferroptosis in melanoma. Application of MitoCur-1 dramatically induces USP14 inhibition and inactivation of GPX4 enzyme, meanwhile, increases the depletion of GSH and decreases SLC7A11 expression level. As a result, ferrous iron-dependent lipid ROS accumulated in the cell, inducing ferroptosis, thus sensitizes the vem-resistant melanoma cell. Interestingly, overexpression of USP14 antagonized all the ferroptosis cascade events induc...
Source: Pigment Cell and Melanoma Research - November 20, 2023 Category: Cytology Authors: Gege Li Changlong Zhou Lu Wang Yalong Zheng Bo Zhou Guoyan Li Zhongyu Ma Peng Sun Yuantao Deng Li Su Junling Wang Hongmei Cui Source Type: research
MitoCur-1 induces ferroptosis to reverse vemurafenib resistance in melanoma through inhibition of USP14
In this study, we have demonstrated that it can work as a novel USP14 inhibitor, and thus bears great potential in providing an anti-tumor effect and sensitizing vem-resistant cells by inducing ferroptosis in melanoma. Application of MitoCur-1 dramatically induces USP14 inhibition and inactivation of GPX4 enzyme, meanwhile, increases the depletion of GSH and decreases SLC7A11 expression level. As a result, ferrous iron-dependent lipid ROS accumulated in the cell, inducing ferroptosis, thus sensitizes the vem-resistant melanoma cell. Interestingly, overexpression of USP14 antagonized all the ferroptosis cascade events induc...
Source: Pigment Cell and Melanoma Research - November 20, 2023 Category: Cytology Authors: Gege Li Changlong Zhou Lu Wang Yalong Zheng Bo Zhou Guoyan Li Zhongyu Ma Peng Sun Yuantao Deng Li Su Junling Wang Hongmei Cui Source Type: research
CD52 mRNA expression predicts prognosis and response to immune checkpoint blockade in melanoma
Pigment Cell Melanoma Res. 2023 Nov 17. doi: 10.1111/pcmr.13151. Online ahead of print.ABSTRACTThe immune-modulating protein CD52 attenuates lymphocyte function and is associated with autoimmune disorders, for example, multiple sclerosis (MS). CD52 represents a therapeutic target in MS and chronic lymphocytic leukemia (CLL). Its expression has prognostic and predictive value in CLL and is prognostic in breast cancer. Its significance in melanoma is unclear. We analyzed CD52 mRNA expression data from tumor bulk tissues of N = 445 untreated melanoma patients from The Cancer Genome Atlas (TCGA) Research Network and of N = 121...
Source: Pigment Cell and Melanoma Research - November 17, 2023 Category: Cytology Authors: Luka de Vos-Hillebrand Simon Fietz Philip Hillebrand Zs ófi Kulcsár Marie Yatou Diop Sarah Hollick Alexander Philippe Maas Sebastian Strieth Jennifer Landsberg Dimo Dietrich Source Type: research
CD52 mRNA expression predicts prognosis and response to immune checkpoint blockade in melanoma
Pigment Cell Melanoma Res. 2023 Nov 17. doi: 10.1111/pcmr.13151. Online ahead of print.ABSTRACTThe immune-modulating protein CD52 attenuates lymphocyte function and is associated with autoimmune disorders, for example, multiple sclerosis (MS). CD52 represents a therapeutic target in MS and chronic lymphocytic leukemia (CLL). Its expression has prognostic and predictive value in CLL and is prognostic in breast cancer. Its significance in melanoma is unclear. We analyzed CD52 mRNA expression data from tumor bulk tissues of N = 445 untreated melanoma patients from The Cancer Genome Atlas (TCGA) Research Network and of N = 121...
Source: Pigment Cell and Melanoma Research - November 17, 2023 Category: Cytology Authors: Luka de Vos-Hillebrand Simon Fietz Philip Hillebrand Zs ófi Kulcsár Marie Yatou Diop Sarah Hollick Alexander Philippe Maas Sebastian Strieth Jennifer Landsberg Dimo Dietrich Source Type: research
CD52 mRNA expression predicts prognosis and response to immune checkpoint blockade in melanoma
Pigment Cell Melanoma Res. 2023 Nov 17. doi: 10.1111/pcmr.13151. Online ahead of print.ABSTRACTThe immune-modulating protein CD52 attenuates lymphocyte function and is associated with autoimmune disorders, for example, multiple sclerosis (MS). CD52 represents a therapeutic target in MS and chronic lymphocytic leukemia (CLL). Its expression has prognostic and predictive value in CLL and is prognostic in breast cancer. Its significance in melanoma is unclear. We analyzed CD52 mRNA expression data from tumor bulk tissues of N = 445 untreated melanoma patients from The Cancer Genome Atlas (TCGA) Research Network and of N = 121...
Source: Pigment Cell and Melanoma Research - November 17, 2023 Category: Cytology Authors: Luka de Vos-Hillebrand Simon Fietz Philip Hillebrand Zs ófi Kulcsár Marie Yatou Diop Sarah Hollick Alexander Philippe Maas Sebastian Strieth Jennifer Landsberg Dimo Dietrich Source Type: research
Single-cell profiling of MC1R-inhibited melanocytes
Pigment Cell Melanoma Res. 2023 Nov 16. doi: 10.1111/pcmr.13141. Online ahead of print.ABSTRACTThe human red hair color (RHC) trait is caused by increased pheomelanin (red-yellow) and reduced eumelanin (black-brown) pigment in skin and hair due to diminished melanocortin 1 receptor (MC1R) function. In addition, individuals harboring the RHC trait are predisposed to melanoma development. While MC1R variants have been established as causative of RHC and are a well-defined risk factor for melanoma, it remains unclear mechanistically why decreased MC1R signaling alters pigmentation and increases melanoma susceptibility. Here, ...
Source: Pigment Cell and Melanoma Research - November 16, 2023 Category: Cytology Authors: H Matthew Berns Dawn E Watkins-Chow Sizhu Lu Pakavarin Louphrasitthiphol Tongwu Zhang Kevin M Brown Pedro Moura-Alves Colin R Goding William J Pavan Source Type: research
TFE3 promotes ferroptosis in melanoma
Pigment Cell Melanoma Res. 2023 Nov 12. doi: 10.1111/pcmr.13149. Online ahead of print.NO ABSTRACTPMID:37953065 | DOI:10.1111/pcmr.13149 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - November 12, 2023 Category: Cytology Authors: Diogo Dias Pakavarin Louphrasitthiphol Colin R Goding Source Type: research
TFE3 promotes ferroptosis in melanoma
Pigment Cell Melanoma Res. 2023 Nov 12. doi: 10.1111/pcmr.13149. Online ahead of print.NO ABSTRACTPMID:37953065 | DOI:10.1111/pcmr.13149 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - November 12, 2023 Category: Cytology Authors: Diogo Dias Pakavarin Louphrasitthiphol Colin R Goding Source Type: research
TFE3 promotes ferroptosis in melanoma
Pigment Cell Melanoma Res. 2023 Nov 12. doi: 10.1111/pcmr.13149. Online ahead of print.NO ABSTRACTPMID:37953065 | DOI:10.1111/pcmr.13149 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - November 12, 2023 Category: Cytology Authors: Diogo Dias Pakavarin Louphrasitthiphol Colin R Goding Source Type: research
TFE3 promotes ferroptosis in melanoma
Pigment Cell Melanoma Res. 2023 Nov 12. doi: 10.1111/pcmr.13149. Online ahead of print.NO ABSTRACTPMID:37953065 | DOI:10.1111/pcmr.13149 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - November 12, 2023 Category: Cytology Authors: Diogo Dias Pakavarin Louphrasitthiphol Colin R Goding Source Type: research
