Melanoma in infants, caused by a gene fusion involving the anaplastic lymphoma kinase (ALK)
We describe the first cases of pediatric melanoma with ALK fusion gene arising within giant congenital melanocytic nevi. Two newborn boys presented with large pigmented nodular plaques and numerous smaller satellite nevi. Additional expansile nodules developed within both nevi and invasive melanomas were diagnosed before 10 months of age in both boys. Oncogenic driver mutations in NRAS and BRAF were absent in both cases. Instead, oncogenic ZEB2::ALK fusion genes were identified in both the nevus and melanoma developing within the nevus. In both cases, tumors were noted by ultrasound in utero, demonstrated significant nodul...
Source: Pigment Cell and Melanoma Research - July 20, 2023 Category: Cytology Authors: Ifeoma U Perkins Serena Y Tan Timothy H McCalmont Pauline M Chou Thaddeus W Mully Pedram Gerami Jason H Pomerantz Miguel Reyes-M úgica Daniel M Balkin Lacey L Kruse Benjamin Huang Jennifer L Reichek Noopur Gangopadhyay Simon Chiosea Jared R Green Sarah L Source Type: research
Histopathologic abundance of pigmentation correlates with disease-specific survival in malignant melanoma but is not independent of current AJCC pT stage
Pigment Cell Melanoma Res. 2023 Jul 20. doi: 10.1111/pcmr.13114. Online ahead of print.ABSTRACTThe increasing number of melanoma patients makes it necessary to develop best possible strategies for prognosis assessment in order to recommend appropriate therapy and follow-up. The prognostic significance of tumor cell pigmentation has not been fully elucidated. Hematoxylin and eosin (H&E)-stained sections of 775 melanomas diagnosed between 2012 and 2015 were independently assessed for melanin pigment abundance by two investigators, and the impact on melanoma-specific survival was calculated. Unpigmented melanomas (n = 99)...
Source: Pigment Cell and Melanoma Research - July 20, 2023 Category: Cytology Authors: Valentin Aebischer Amar Abu-Ghazaleh Gisela Metzler Lena Riedl Claus Garbe Lukas Flatz Thomas Eigentler Stephan Forchhammer Source Type: research
Melanoma in infants, caused by a gene fusion involving the anaplastic lymphoma kinase (ALK)
We describe the first cases of pediatric melanoma with ALK fusion gene arising within giant congenital melanocytic nevi. Two newborn boys presented with large pigmented nodular plaques and numerous smaller satellite nevi. Additional expansile nodules developed within both nevi and invasive melanomas were diagnosed before 10 months of age in both boys. Oncogenic driver mutations in NRAS and BRAF were absent in both cases. Instead, oncogenic ZEB2::ALK fusion genes were identified in both the nevus and melanoma developing within the nevus. In both cases, tumors were noted by ultrasound in utero, demonstrated significant nodul...
Source: Pigment Cell and Melanoma Research - July 20, 2023 Category: Cytology Authors: Ifeoma U Perkins Serena Y Tan Timothy H McCalmont Pauline M Chou Thaddeus W Mully Pedram Gerami Jason H Pomerantz Miguel Reyes-M úgica Daniel M Balkin Lacey L Kruse Benjamin Huang Jennifer L Reichek Noopur Gangopadhyay Simon Chiosea Jared R Green Sarah L Source Type: research
Histopathologic abundance of pigmentation correlates with disease-specific survival in malignant melanoma but is not independent of current AJCC pT stage
Pigment Cell Melanoma Res. 2023 Jul 20. doi: 10.1111/pcmr.13114. Online ahead of print.ABSTRACTThe increasing number of melanoma patients makes it necessary to develop best possible strategies for prognosis assessment in order to recommend appropriate therapy and follow-up. The prognostic significance of tumor cell pigmentation has not been fully elucidated. Hematoxylin and eosin (H&E)-stained sections of 775 melanomas diagnosed between 2012 and 2015 were independently assessed for melanin pigment abundance by two investigators, and the impact on melanoma-specific survival was calculated. Unpigmented melanomas (n = 99)...
Source: Pigment Cell and Melanoma Research - July 20, 2023 Category: Cytology Authors: Valentin Aebischer Amar Abu-Ghazaleh Gisela Metzler Lena Riedl Claus Garbe Lukas Flatz Thomas Eigentler Stephan Forchhammer Source Type: research
Melanoma in infants, caused by a gene fusion involving the anaplastic lymphoma kinase (ALK)
We describe the first cases of pediatric melanoma with ALK fusion gene arising within giant congenital melanocytic nevi. Two newborn boys presented with large pigmented nodular plaques and numerous smaller satellite nevi. Additional expansile nodules developed within both nevi and invasive melanomas were diagnosed before 10 months of age in both boys. Oncogenic driver mutations in NRAS and BRAF were absent in both cases. Instead, oncogenic ZEB2::ALK fusion genes were identified in both the nevus and melanoma developing within the nevus. In both cases, tumors were noted by ultrasound in utero, demonstrated significant nodul...
Source: Pigment Cell and Melanoma Research - July 20, 2023 Category: Cytology Authors: Ifeoma U Perkins Serena Y Tan Timothy H McCalmont Pauline M Chou Thaddeus W Mully Pedram Gerami Jason H Pomerantz Miguel Reyes-M úgica Daniel M Balkin Lacey L Kruse Benjamin Huang Jennifer L Reichek Noopur Gangopadhyay Simon Chiosea Jared R Green Sarah L Source Type: research
Histopathologic abundance of pigmentation correlates with disease-specific survival in malignant melanoma but is not independent of current AJCC pT stage
Pigment Cell Melanoma Res. 2023 Jul 20. doi: 10.1111/pcmr.13114. Online ahead of print.ABSTRACTThe increasing number of melanoma patients makes it necessary to develop best possible strategies for prognosis assessment in order to recommend appropriate therapy and follow-up. The prognostic significance of tumor cell pigmentation has not been fully elucidated. Hematoxylin and eosin (H&E)-stained sections of 775 melanomas diagnosed between 2012 and 2015 were independently assessed for melanin pigment abundance by two investigators, and the impact on melanoma-specific survival was calculated. Unpigmented melanomas (n = 99)...
Source: Pigment Cell and Melanoma Research - July 20, 2023 Category: Cytology Authors: Valentin Aebischer Amar Abu-Ghazaleh Gisela Metzler Lena Riedl Claus Garbe Lukas Flatz Thomas Eigentler Stephan Forchhammer Source Type: research
Melanoma in infants, caused by a gene fusion involving the anaplastic lymphoma kinase (ALK)
We describe the first cases of pediatric melanoma with ALK fusion gene arising within giant congenital melanocytic nevi. Two newborn boys presented with large pigmented nodular plaques and numerous smaller satellite nevi. Additional expansile nodules developed within both nevi and invasive melanomas were diagnosed before 10 months of age in both boys. Oncogenic driver mutations in NRAS and BRAF were absent in both cases. Instead, oncogenic ZEB2::ALK fusion genes were identified in both the nevus and melanoma developing within the nevus. In both cases, tumors were noted by ultrasound in utero, demonstrated significant nodul...
Source: Pigment Cell and Melanoma Research - July 20, 2023 Category: Cytology Authors: Ifeoma U Perkins Serena Y Tan Timothy H McCalmont Pauline M Chou Thaddeus W Mully Pedram Gerami Jason H Pomerantz Miguel Reyes-M úgica Daniel M Balkin Lacey L Kruse Benjamin Huang Jennifer L Reichek Noopur Gangopadhyay Simon Chiosea Jared R Green Sarah L Source Type: research
Histopathologic abundance of pigmentation correlates with disease-specific survival in malignant melanoma but is not independent of current AJCC pT stage
Pigment Cell Melanoma Res. 2023 Jul 20. doi: 10.1111/pcmr.13114. Online ahead of print.ABSTRACTThe increasing number of melanoma patients makes it necessary to develop best possible strategies for prognosis assessment in order to recommend appropriate therapy and follow-up. The prognostic significance of tumor cell pigmentation has not been fully elucidated. Hematoxylin and eosin (H&E)-stained sections of 775 melanomas diagnosed between 2012 and 2015 were independently assessed for melanin pigment abundance by two investigators, and the impact on melanoma-specific survival was calculated. Unpigmented melanomas (n = 99)...
Source: Pigment Cell and Melanoma Research - July 20, 2023 Category: Cytology Authors: Valentin Aebischer Amar Abu-Ghazaleh Gisela Metzler Lena Riedl Claus Garbe Lukas Flatz Thomas Eigentler Stephan Forchhammer Source Type: research
Melanoma in infants, caused by a gene fusion involving the anaplastic lymphoma kinase (ALK)
We describe the first cases of pediatric melanoma with ALK fusion gene arising within giant congenital melanocytic nevi. Two newborn boys presented with large pigmented nodular plaques and numerous smaller satellite nevi. Additional expansile nodules developed within both nevi and invasive melanomas were diagnosed before 10 months of age in both boys. Oncogenic driver mutations in NRAS and BRAF were absent in both cases. Instead, oncogenic ZEB2::ALK fusion genes were identified in both the nevus and melanoma developing within the nevus. In both cases, tumors were noted by ultrasound in utero, demonstrated significant nodul...
Source: Pigment Cell and Melanoma Research - July 20, 2023 Category: Cytology Authors: Ifeoma U Perkins Serena Y Tan Timothy H McCalmont Pauline M Chou Thaddeus W Mully Pedram Gerami Jason H Pomerantz Miguel Reyes-M úgica Daniel M Balkin Lacey L Kruse Benjamin Huang Jennifer L Reichek Noopur Gangopadhyay Simon Chiosea Jared R Green Sarah L Source Type: research
Histopathologic abundance of pigmentation correlates with disease-specific survival in malignant melanoma but is not independent of current AJCC pT stage
Pigment Cell Melanoma Res. 2023 Jul 20. doi: 10.1111/pcmr.13114. Online ahead of print.ABSTRACTThe increasing number of melanoma patients makes it necessary to develop best possible strategies for prognosis assessment in order to recommend appropriate therapy and follow-up. The prognostic significance of tumor cell pigmentation has not been fully elucidated. Hematoxylin and eosin (H&E)-stained sections of 775 melanomas diagnosed between 2012 and 2015 were independently assessed for melanin pigment abundance by two investigators, and the impact on melanoma-specific survival was calculated. Unpigmented melanomas (n = 99)...
Source: Pigment Cell and Melanoma Research - July 20, 2023 Category: Cytology Authors: Valentin Aebischer Amar Abu-Ghazaleh Gisela Metzler Lena Riedl Claus Garbe Lukas Flatz Thomas Eigentler Stephan Forchhammer Source Type: research
Melanoma in infants, caused by a gene fusion involving the anaplastic lymphoma kinase (ALK)
We describe the first cases of pediatric melanoma with ALK fusion gene arising within giant congenital melanocytic nevi. Two newborn boys presented with large pigmented nodular plaques and numerous smaller satellite nevi. Additional expansile nodules developed within both nevi and invasive melanomas were diagnosed before 10 months of age in both boys. Oncogenic driver mutations in NRAS and BRAF were absent in both cases. Instead, oncogenic ZEB2::ALK fusion genes were identified in both the nevus and melanoma developing within the nevus. In both cases, tumors were noted by ultrasound in utero, demonstrated significant nodul...
Source: Pigment Cell and Melanoma Research - July 20, 2023 Category: Cytology Authors: Ifeoma U Perkins Serena Y Tan Timothy H McCalmont Pauline M Chou Thaddeus W Mully Pedram Gerami Jason H Pomerantz Miguel Reyes-M úgica Daniel M Balkin Lacey L Kruse Benjamin Huang Jennifer L Reichek Noopur Gangopadhyay Simon Chiosea Jared R Green Sarah L Source Type: research
Histopathologic abundance of pigmentation correlates with disease-specific survival in malignant melanoma but is not independent of current AJCC pT stage
Pigment Cell Melanoma Res. 2023 Jul 20. doi: 10.1111/pcmr.13114. Online ahead of print.ABSTRACTThe increasing number of melanoma patients makes it necessary to develop best possible strategies for prognosis assessment in order to recommend appropriate therapy and follow-up. The prognostic significance of tumor cell pigmentation has not been fully elucidated. Hematoxylin and eosin (H&E)-stained sections of 775 melanomas diagnosed between 2012 and 2015 were independently assessed for melanin pigment abundance by two investigators, and the impact on melanoma-specific survival was calculated. Unpigmented melanomas (n = 99)...
Source: Pigment Cell and Melanoma Research - July 20, 2023 Category: Cytology Authors: Valentin Aebischer Amar Abu-Ghazaleh Gisela Metzler Lena Riedl Claus Garbe Lukas Flatz Thomas Eigentler Stephan Forchhammer Source Type: research
Melanoma in infants, caused by a gene fusion involving the anaplastic lymphoma kinase (ALK)
We describe the first cases of pediatric melanoma with ALK fusion gene arising within giant congenital melanocytic nevi. Two newborn boys presented with large pigmented nodular plaques and numerous smaller satellite nevi. Additional expansile nodules developed within both nevi and invasive melanomas were diagnosed before 10 months of age in both boys. Oncogenic driver mutations in NRAS and BRAF were absent in both cases. Instead, oncogenic ZEB2::ALK fusion genes were identified in both the nevus and melanoma developing within the nevus. In both cases, tumors were noted by ultrasound in utero, demonstrated significant nodul...
Source: Pigment Cell and Melanoma Research - July 20, 2023 Category: Cytology Authors: Ifeoma U Perkins Serena Y Tan Timothy H McCalmont Pauline M Chou Thaddeus W Mully Pedram Gerami Jason H Pomerantz Miguel Reyes-M úgica Daniel M Balkin Lacey L Kruse Benjamin Huang Jennifer L Reichek Noopur Gangopadhyay Simon Chiosea Jared R Green Sarah L Source Type: research
Histopathologic abundance of pigmentation correlates with disease-specific survival in malignant melanoma but is not independent of current AJCC pT stage
Pigment Cell Melanoma Res. 2023 Jul 20. doi: 10.1111/pcmr.13114. Online ahead of print.ABSTRACTThe increasing number of melanoma patients makes it necessary to develop best possible strategies for prognosis assessment in order to recommend appropriate therapy and follow-up. The prognostic significance of tumor cell pigmentation has not been fully elucidated. Hematoxylin and eosin (H&E)-stained sections of 775 melanomas diagnosed between 2012 and 2015 were independently assessed for melanin pigment abundance by two investigators, and the impact on melanoma-specific survival was calculated. Unpigmented melanomas (n = 99)...
Source: Pigment Cell and Melanoma Research - July 20, 2023 Category: Cytology Authors: Valentin Aebischer Amar Abu-Ghazaleh Gisela Metzler Lena Riedl Claus Garbe Lukas Flatz Thomas Eigentler Stephan Forchhammer Source Type: research
Melanoma in infants, caused by a gene fusion involving the anaplastic lymphoma kinase (ALK)
We describe the first cases of pediatric melanoma with ALK fusion gene arising within giant congenital melanocytic nevi. Two newborn boys presented with large pigmented nodular plaques and numerous smaller satellite nevi. Additional expansile nodules developed within both nevi and invasive melanomas were diagnosed before 10 months of age in both boys. Oncogenic driver mutations in NRAS and BRAF were absent in both cases. Instead, oncogenic ZEB2::ALK fusion genes were identified in both the nevus and melanoma developing within the nevus. In both cases, tumors were noted by ultrasound in utero, demonstrated significant nodul...
Source: Pigment Cell and Melanoma Research - July 20, 2023 Category: Cytology Authors: Ifeoma U Perkins Serena Y Tan Timothy H McCalmont Pauline M Chou Thaddeus W Mully Pedram Gerami Jason H Pomerantz Miguel Reyes-M úgica Daniel M Balkin Lacey L Kruse Benjamin Huang Jennifer L Reichek Noopur Gangopadhyay Simon Chiosea Jared R Green Sarah L Source Type: research
