Neutrophil-to-eosinophil ratio as a biomarker for clinical outcomes in advanced stage melanoma patients treated with anti-PD-1 therapy
Pigment Cell Melanoma Res. 2023 Nov;36(6):501-511. doi: 10.1111/pcmr.13109. Epub 2023 Jul 7.ABSTRACTNeutrophil-to-lymphocyte ratios (NLR) and eosinophil counts are associated with improved survival in melanoma patients treated with immune checkpoint inhibitors, but no study has investigated neutrophil-to-eosinophil ratios (NER) as a predictive indicator in this population. In this retrospective study evaluating anti-PD-1 treated patients with advanced melanoma, progression-free survival (PFS), overall survival (OS), objective response rates (ORR), and risk of high-grade (grade ≥3) immune-related adverse events (irAEs) we...
Source: Pigment Cell and Melanoma Research - October 30, 2023 Category: Cytology Authors: Vincent Pozorski Yeonhee Park Yusuf Mohamoud Dahlia Tesfamichael Hamid Emamekhoo Alexander Birbrair Mark R Albertini Vincent T Ma Source Type: research
Epilogue
Pigment Cell Melanoma Res. 2023 Nov;36(6):454. doi: 10.1111/pcmr.13143.NO ABSTRACTPMID:37903734 | DOI:10.1111/pcmr.13143 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - October 30, 2023 Category: Cytology Authors: Vijayasaradhi Setaluri Evan P And Marion Helfaer Source Type: research
20th Anniversary of the Society for Melanoma Research: Celebrating two decades of progress in melanoma research
Pigment Cell Melanoma Res. 2023 Nov;36(6):562. doi: 10.1111/pcmr.13134.NO ABSTRACTPMID:37903735 | DOI:10.1111/pcmr.13134 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - October 30, 2023 Category: Cytology Authors: Ravi Amaravadi Andrew Aplin Meenhard Herlyn Sheri Holmen Richard White Jessie Villanueva Source Type: research
Neutrophil-to-eosinophil ratio as a biomarker for clinical outcomes in advanced stage melanoma patients treated with anti-PD-1 therapy
Pigment Cell Melanoma Res. 2023 Nov;36(6):501-511. doi: 10.1111/pcmr.13109. Epub 2023 Jul 7.ABSTRACTNeutrophil-to-lymphocyte ratios (NLR) and eosinophil counts are associated with improved survival in melanoma patients treated with immune checkpoint inhibitors, but no study has investigated neutrophil-to-eosinophil ratios (NER) as a predictive indicator in this population. In this retrospective study evaluating anti-PD-1 treated patients with advanced melanoma, progression-free survival (PFS), overall survival (OS), objective response rates (ORR), and risk of high-grade (grade ≥3) immune-related adverse events (irAEs) we...
Source: Pigment Cell and Melanoma Research - October 30, 2023 Category: Cytology Authors: Vincent Pozorski Yeonhee Park Yusuf Mohamoud Dahlia Tesfamichael Hamid Emamekhoo Alexander Birbrair Mark R Albertini Vincent T Ma Source Type: research
Epilogue
Pigment Cell Melanoma Res. 2023 Nov;36(6):454. doi: 10.1111/pcmr.13143.NO ABSTRACTPMID:37903734 | DOI:10.1111/pcmr.13143 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - October 30, 2023 Category: Cytology Authors: Vijayasaradhi Setaluri Evan P And Marion Helfaer Source Type: research
20th Anniversary of the Society for Melanoma Research: Celebrating two decades of progress in melanoma research
Pigment Cell Melanoma Res. 2023 Nov;36(6):562. doi: 10.1111/pcmr.13134.NO ABSTRACTPMID:37903735 | DOI:10.1111/pcmr.13134 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - October 30, 2023 Category: Cytology Authors: Ravi Amaravadi Andrew Aplin Meenhard Herlyn Sheri Holmen Richard White Jessie Villanueva Source Type: research
List of reviewers for PCMR (01.01.2023-30.09.2023)
Pigment Cell Melanoma Res. 2023 Nov;36(6):557-561. doi: 10.1111/pcmr.13142.NO ABSTRACTPMID:37903736 | DOI:10.1111/pcmr.13142 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - October 30, 2023 Category: Cytology Source Type: research
Clinicopathological features, current status, and progress of primary central nervous system melanoma diagnosis and treatment
Pigment Cell Melanoma Res. 2023 Oct 27. doi: 10.1111/pcmr.13140. Online ahead of print.ABSTRACTPrimary central nervous system (CNS) melanoma is an extremely rare condition, with an incidence rate of 0.01 per 100,000 individuals per year. Despite its rarity, the etiology and pathogenesis of this disease are not yet fully understood. Primary CNS melanoma exhibits highly aggressive biological behavior and presents clinically in a distinct manner from other types of melanomas. It can develop at any age, predominantly affecting the meninges as the primary site, with clinical symptoms varying depending on the neoplasm's location...
Source: Pigment Cell and Melanoma Research - October 27, 2023 Category: Cytology Authors: Pengna Guo Xiaoting Wei Zhen Guo Di Wu Source Type: research
Clinicopathological features, current status, and progress of primary central nervous system melanoma diagnosis and treatment
Pigment Cell Melanoma Res. 2023 Oct 27. doi: 10.1111/pcmr.13140. Online ahead of print.ABSTRACTPrimary central nervous system (CNS) melanoma is an extremely rare condition, with an incidence rate of 0.01 per 100,000 individuals per year. Despite its rarity, the etiology and pathogenesis of this disease are not yet fully understood. Primary CNS melanoma exhibits highly aggressive biological behavior and presents clinically in a distinct manner from other types of melanomas. It can develop at any age, predominantly affecting the meninges as the primary site, with clinical symptoms varying depending on the neoplasm's location...
Source: Pigment Cell and Melanoma Research - October 27, 2023 Category: Cytology Authors: Pengna Guo Xiaoting Wei Zhen Guo Di Wu Source Type: research
Clinicopathological features, current status, and progress of primary central nervous system melanoma diagnosis and treatment
Pigment Cell Melanoma Res. 2023 Oct 27. doi: 10.1111/pcmr.13140. Online ahead of print.ABSTRACTPrimary central nervous system (CNS) melanoma is an extremely rare condition, with an incidence rate of 0.01 per 100,000 individuals per year. Despite its rarity, the etiology and pathogenesis of this disease are not yet fully understood. Primary CNS melanoma exhibits highly aggressive biological behavior and presents clinically in a distinct manner from other types of melanomas. It can develop at any age, predominantly affecting the meninges as the primary site, with clinical symptoms varying depending on the neoplasm's location...
Source: Pigment Cell and Melanoma Research - October 27, 2023 Category: Cytology Authors: Pengna Guo Xiaoting Wei Zhen Guo Di Wu Source Type: research
The MFSD12 p.Tyr182His common variant is sufficient to alter mouse agouti coat color
Pigment Cell Melanoma Res. 2023 Oct 24. doi: 10.1111/pcmr.13144. Online ahead of print.ABSTRACTMFSD12 functions as a transmembrane protein required for import of cysteine into melanosomes and lysosomes. The MFSD12 locus has been associated with phenotypic variation in skin color across African, Latin American, and East Asian populations. The frequency of a particular MFSD12 coding variant, rs2240751 (MAF = 0.08), has been reported to correlate with solar radiation and occur at highest frequency in Peruvian (PEL MAF = 0.48) and Han Chinese (CHB MAF = 0.40) populations, suggesting it could be causative for associated phenoty...
Source: Pigment Cell and Melanoma Research - October 24, 2023 Category: Cytology Authors: Dawn E Watkins-Chow Arturo A Incao Cecelia Rivas Gene Elliott Lisa J Garrett William J Pavan Source Type: research
The MFSD12 p.Tyr182His common variant is sufficient to alter mouse agouti coat color
Pigment Cell Melanoma Res. 2023 Oct 24. doi: 10.1111/pcmr.13144. Online ahead of print.ABSTRACTMFSD12 functions as a transmembrane protein required for import of cysteine into melanosomes and lysosomes. The MFSD12 locus has been associated with phenotypic variation in skin color across African, Latin American, and East Asian populations. The frequency of a particular MFSD12 coding variant, rs2240751 (MAF = 0.08), has been reported to correlate with solar radiation and occur at highest frequency in Peruvian (PEL MAF = 0.48) and Han Chinese (CHB MAF = 0.40) populations, suggesting it could be causative for associated phenoty...
Source: Pigment Cell and Melanoma Research - October 24, 2023 Category: Cytology Authors: Dawn E Watkins-Chow Arturo A Incao Cecelia Rivas Gene Elliott Lisa J Garrett William J Pavan Source Type: research
The MFSD12 p.Tyr182His common variant is sufficient to alter mouse agouti coat color
Pigment Cell Melanoma Res. 2023 Oct 24. doi: 10.1111/pcmr.13144. Online ahead of print.ABSTRACTMFSD12 functions as a transmembrane protein required for import of cysteine into melanosomes and lysosomes. The MFSD12 locus has been associated with phenotypic variation in skin color across African, Latin American, and East Asian populations. The frequency of a particular MFSD12 coding variant, rs2240751 (MAF = 0.08), has been reported to correlate with solar radiation and occur at highest frequency in Peruvian (PEL MAF = 0.48) and Han Chinese (CHB MAF = 0.40) populations, suggesting it could be causative for associated phenoty...
Source: Pigment Cell and Melanoma Research - October 24, 2023 Category: Cytology Authors: Dawn E Watkins-Chow Arturo A Incao Cecelia Rivas Gene Elliott Lisa J Garrett William J Pavan Source Type: research
Next-generation of melanoma researchers: Trainee perspectives from around the world
Pigment Cell Melanoma Res. 2023 Oct 11. doi: 10.1111/pcmr.13136. Online ahead of print.ABSTRACTThe Society for Melanoma Research (SMR) was created 20 years ago and has unequivocally contributed to the vast progress of the field, particularly for the treatment of melanoma patients with metastatic disease by facilitating synergistic collaborations between clinicians, researchers at the bench, and industry. In commemoration of the 20th anniversary of the first SMR International Congress (held in 2003 in Philadelphia), we look to the future by highlighting the perspectives of the next generation of rising stars, medical, and g...
Source: Pigment Cell and Melanoma Research - October 11, 2023 Category: Cytology Authors: Marie R Webster Roderick Brathwaite Jeremy A Bravo Narula Vissy E Elad Yanni Ma Mei Fong Ng Manoel Oliveira de Moraes Junior Majahonkhe Shabangu Christina Tsiavou Jessie Villanueva Vito W Rebecca Source Type: research
Progress in melanoma treatment: Patient's perspectives
Pigment Cell Melanoma Res. 2023 Oct 11. doi: 10.1111/pcmr.13138. Online ahead of print.ABSTRACTUpon the 20th Anniversary of the Society for Melanoma Research, we highlight the perspectives of patients aiming to help improve future experiences, outcomes, and their quality of life over the next 20 years. Five melanoma patients generously shared their inspiring and enlightening stories of diagnosis, treatment, and outcomes. Many patients had excellent medical teams that synergistically worked together to provide an accurate diagnosis, effective treatment options, and supportive care. However, it is clear that health inequitie...
Source: Pigment Cell and Melanoma Research - October 11, 2023 Category: Cytology Authors: Gretchen M Alicea Jessie Villanueva Marie R Webster Vito W Rebecca Source Type: research
