The Yucatan miniature swine as a model for post-inflammatory hyperpigmentation
Pigment Cell Melanoma Res. 2024 Feb 16. doi: 10.1111/pcmr.13162. Online ahead of print.ABSTRACTPost-inflammatory hyperpigmentation (PIH) is a hypermelanosis that often occurs secondary to skin irritation or injury, especially in darker skin tones, for which there is currently a lack of effective treatment options. Few preclinical models are available to study PIH. Here, we show that the Yucatan miniature pig consistently develops PIH after skin injuries. Skin wounds were produced on Yucatan pigs by needle punches, full-thickness excisions, or burns. Wound sites were monitored and photographed regularly. Tissue samples were...
Source: Pigment Cell and Melanoma Research - February 16, 2024 Category: Cytology Authors: Ying Wang Emilee Herringshaw R Rox Anderson Joshua Tam Source Type: research
Review: Are moles senescent?
In conclusion, there is strong evidence that cells of acquired human benign (banal) nevi are very largely senescent, though some must contain a minor non-senescent cell subpopulation. There is also persuasive evidence that this senescence is primarily induced by dysfunctional telomeres rather than directly oncogene-induced.PMID:38361107 | DOI:10.1111/pcmr.13163 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - February 16, 2024 Category: Cytology Authors: Dorothy C Bennett Source Type: research
The Yucatan miniature swine as a model for post-inflammatory hyperpigmentation
Pigment Cell Melanoma Res. 2024 Feb 16. doi: 10.1111/pcmr.13162. Online ahead of print.ABSTRACTPost-inflammatory hyperpigmentation (PIH) is a hypermelanosis that often occurs secondary to skin irritation or injury, especially in darker skin tones, for which there is currently a lack of effective treatment options. Few preclinical models are available to study PIH. Here, we show that the Yucatan miniature pig consistently develops PIH after skin injuries. Skin wounds were produced on Yucatan pigs by needle punches, full-thickness excisions, or burns. Wound sites were monitored and photographed regularly. Tissue samples were...
Source: Pigment Cell and Melanoma Research - February 16, 2024 Category: Cytology Authors: Ying Wang Emilee Herringshaw R Rox Anderson Joshua Tam Source Type: research
Review: Are moles senescent?
In conclusion, there is strong evidence that cells of acquired human benign (banal) nevi are very largely senescent, though some must contain a minor non-senescent cell subpopulation. There is also persuasive evidence that this senescence is primarily induced by dysfunctional telomeres rather than directly oncogene-induced.PMID:38361107 | DOI:10.1111/pcmr.13163 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - February 16, 2024 Category: Cytology Authors: Dorothy C Bennett Source Type: research
The Yucatan miniature swine as a model for post-inflammatory hyperpigmentation
Pigment Cell Melanoma Res. 2024 Feb 16. doi: 10.1111/pcmr.13162. Online ahead of print.ABSTRACTPost-inflammatory hyperpigmentation (PIH) is a hypermelanosis that often occurs secondary to skin irritation or injury, especially in darker skin tones, for which there is currently a lack of effective treatment options. Few preclinical models are available to study PIH. Here, we show that the Yucatan miniature pig consistently develops PIH after skin injuries. Skin wounds were produced on Yucatan pigs by needle punches, full-thickness excisions, or burns. Wound sites were monitored and photographed regularly. Tissue samples were...
Source: Pigment Cell and Melanoma Research - February 16, 2024 Category: Cytology Authors: Ying Wang Emilee Herringshaw R Rox Anderson Joshua Tam Source Type: research
Vitiligo non-responding lesions to narrow band UVB have intriguing cellular and molecular abnormalities that may prevent epidermal repigmentation
Pigment Cell Melanoma Res. 2024 Feb 11. doi: 10.1111/pcmr.13160. Online ahead of print.ABSTRACTWe have discovered that human vitiligo patients treated with narrow-band UVB (NBUVB) demonstrated localized resistance to repigmentation in skin sites characterized by distinct cellular and molecular pathways. Using immunostaining studies, discovery-stage RNA-Seq analysis, and confirmatory in situ hybridization, we analyzed paired biopsies collected from vitiligo lesions that did not repigment after 6 months of NBUVB treatment (non-responding) and compared them with repigmented (responding) lesions from the same patient. Non-resp...
Source: Pigment Cell and Melanoma Research - February 12, 2024 Category: Cytology Authors: Nathaniel B Goldstein Andrea Steel Landon Tomb Zachary Berk Junxiao Hu Velmurugan Balaya Laura Hoaglin Kavya Ganuthula Meet Patel Erica Mbika William A Robinson Dennis R Roop David A Norris Stanca A Birlea Source Type: research
The 20th International Congress of the Society for Melanoma Research
Pigment Cell Melanoma Res. 2024 Jan;37(1):90-226. doi: 10.1111/pcmr.13152.NO ABSTRACTPMID:38213075 | DOI:10.1111/pcmr.13152 (Source: Pigment Cell and Melanoma Research)
Source: Pigment Cell and Melanoma Research - January 12, 2024 Category: Cytology Source Type: research
Molecular skin fluorescence imaging: A tool for evaluating early melanoma development
Pigment Cell Melanoma Res. 2024 Jan 4. doi: 10.1111/pcmr.13159. Online ahead of print.ABSTRACTA novel approach to melanoma diagnosis-in vivo molecular skin fluorescence imaging (mSFI)-was developed to identify premalignant changes in the form of tissue remodeling related to melanoma development in humans by imaging the proximal microenvironment of lesions. The method was tested using a fluorescent peptide (ORL-1) which binds to αvβ3 integrin, a molecule associated with invasive melanoma development. A cut off score of 7 was established, differentiating melanomas from nonmelanoma nevi with 100% sensitivity, and 95.7% spec...
Source: Pigment Cell and Melanoma Research - January 5, 2024 Category: Cytology Authors: Amit Shachaf Kevin Manbeck Guang Yang Catherine Shachaf Source Type: research
Molecular skin fluorescence imaging: A tool for evaluating early melanoma development
Pigment Cell Melanoma Res. 2024 Jan 4. doi: 10.1111/pcmr.13159. Online ahead of print.ABSTRACTA novel approach to melanoma diagnosis-in vivo molecular skin fluorescence imaging (mSFI)-was developed to identify premalignant changes in the form of tissue remodeling related to melanoma development in humans by imaging the proximal microenvironment of lesions. The method was tested using a fluorescent peptide (ORL-1) which binds to αvβ3 integrin, a molecule associated with invasive melanoma development. A cut off score of 7 was established, differentiating melanomas from nonmelanoma nevi with 100% sensitivity, and 95.7% spec...
Source: Pigment Cell and Melanoma Research - January 5, 2024 Category: Cytology Authors: Amit Shachaf Kevin Manbeck Guang Yang Catherine Shachaf Source Type: research
Molecular skin fluorescence imaging: A tool for evaluating early melanoma development
Pigment Cell Melanoma Res. 2024 Jan 4. doi: 10.1111/pcmr.13159. Online ahead of print.ABSTRACTA novel approach to melanoma diagnosis-in vivo molecular skin fluorescence imaging (mSFI)-was developed to identify premalignant changes in the form of tissue remodeling related to melanoma development in humans by imaging the proximal microenvironment of lesions. The method was tested using a fluorescent peptide (ORL-1) which binds to αvβ3 integrin, a molecule associated with invasive melanoma development. A cut off score of 7 was established, differentiating melanomas from nonmelanoma nevi with 100% sensitivity, and 95.7% spec...
Source: Pigment Cell and Melanoma Research - January 5, 2024 Category: Cytology Authors: Amit Shachaf Kevin Manbeck Guang Yang Catherine Shachaf Source Type: research
Molecular skin fluorescence imaging: A tool for evaluating early melanoma development
Pigment Cell Melanoma Res. 2024 Jan 4. doi: 10.1111/pcmr.13159. Online ahead of print.ABSTRACTA novel approach to melanoma diagnosis-in vivo molecular skin fluorescence imaging (mSFI)-was developed to identify premalignant changes in the form of tissue remodeling related to melanoma development in humans by imaging the proximal microenvironment of lesions. The method was tested using a fluorescent peptide (ORL-1) which binds to αvβ3 integrin, a molecule associated with invasive melanoma development. A cut off score of 7 was established, differentiating melanomas from nonmelanoma nevi with 100% sensitivity, and 95.7% spec...
Source: Pigment Cell and Melanoma Research - January 5, 2024 Category: Cytology Authors: Amit Shachaf Kevin Manbeck Guang Yang Catherine Shachaf Source Type: research
Molecular skin fluorescence imaging: A tool for evaluating early melanoma development
Pigment Cell Melanoma Res. 2024 Jan 4. doi: 10.1111/pcmr.13159. Online ahead of print.ABSTRACTA novel approach to melanoma diagnosis-in vivo molecular skin fluorescence imaging (mSFI)-was developed to identify premalignant changes in the form of tissue remodeling related to melanoma development in humans by imaging the proximal microenvironment of lesions. The method was tested using a fluorescent peptide (ORL-1) which binds to αvβ3 integrin, a molecule associated with invasive melanoma development. A cut off score of 7 was established, differentiating melanomas from nonmelanoma nevi with 100% sensitivity, and 95.7% spec...
Source: Pigment Cell and Melanoma Research - January 5, 2024 Category: Cytology Authors: Amit Shachaf Kevin Manbeck Guang Yang Catherine Shachaf Source Type: research
The role of dacarbazine and temozolomide therapy after treatment with immune checkpoint inhibitors in malignant melanoma patients: A case series and meta-analysis
Pigment Cell Melanoma Res. 2023 Dec 29. doi: 10.1111/pcmr.13156. Online ahead of print.ABSTRACTDacarbazine (DTIC) and its oral counterpart temozolomide (TMZ) have been the most used agents in advanced malignant melanoma (MM) patients and they are still used routinely. The preferred first line treatment, immune checkpoint inhibitors (CPIs) might shape the tumor and the tumor microenvironment, possibly affecting the response to subsequent therapies. The aim of this study was to investigate the treatment effect of DTIC/TMZ in MM patients after CPI therapy in a consecutive patient cohort and through systematic literature revie...
Source: Pigment Cell and Melanoma Research - December 29, 2023 Category: Cytology Authors: Viktoria Ryd én Ali Inan El-Naggar Anthoula Koliadi Cecilia Olsson Ladjevardi Evangelos Digkas Antonios Valachis Gustav J Ullenhag Source Type: research
Comprehensive molecular findings in primary malignant melanoma of the esophagus: A multicenter study
This study reviewed 26 PMME cases from three medical centers. Hybrid capture-based targeted sequencing of 295 and 1021 genes was performed in 14 and 12 cases, respectively. We found that PMME patients had a relatively low tumor mutation burden (median, 2.88 mutations per Mb) and were simultaneously accompanied by mutations in genes such as KIT (6/26, 23%), TP53 (6/26, 23%), SF3B1 (4/26, 15%), and NRAS (3/26, 12%). KIT, NRAS, and BRAF were mutually exclusive, and SF3B1 co-occurred with KIT mutation and amplification. The most common pathways affected were the mitogen-activated protein kinases and DNA damage response (DDR) p...
Source: Pigment Cell and Melanoma Research - December 29, 2023 Category: Cytology Authors: Ling Deng Hai-Yun Wang Chun-Fang Hu Xiao-Yun Liu Kuntai Jiang Juan-Juan Yong Xiao-Yan Wu Kai-Hua Guo Fang Wang Source Type: research
Small extracellular vesicle-based human melanocyte and melanoma signature
Pigment Cell Melanoma Res. 2023 Dec 29. doi: 10.1111/pcmr.13158. Online ahead of print.ABSTRACTIntercellular communication is a cell-type and stimulus-dependent event driven not only by soluble factors but also by extracellular vesicles (EVs). EVs include vesicles of different size and origin that contain a myriad of molecules. Among them, small EVs (sEV; <200 nm) have been shown to modulate not just regional cell responses but also distant organ behavior. In cancer, distant organ modulation by sEVs has been associated to disease dissemination, which is one of the main concerns in melanoma. Description of broadly conser...
Source: Pigment Cell and Melanoma Research - December 29, 2023 Category: Cytology Authors: Andrea Ag üera-Lorente Ainhoa Alonso-Pardavila Mar ía Larrinaga Mar ía Dolores Boyano Esperanza Gonz ález Juan Manuel Falc ón-Pérez Aintzane Asumendi Aintzane Apraiz Source Type: research
