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Effect of tenofovir containing ART on renal function in patients with moderate/severe reduced creatinine clearance at baseline: A retrospective study at two referral hospitals in Namibia
Panel A shows median CrCl values for patients in the four stages of CrCl at baseline. Panel B shows the follow-up median CrCl for the same baseline stages. A drop is observed for stages 1 and 2, while increases are observed for stages 3 and 4. AbstractPrescription of tenofovir disoproxil fumarate (TDF) for patients with baseline creatinine clearances (CrCl)<60  mL/min is said to increase risk of further decline in CrCl. Study objectives were to assess incidence of improvement and predictors thereof; to assess incidence of decline and transition to lower stages of CrCl; and comparison of declines between patients with a...
Source: Pharmacology Research and Perspectives - December 31, 2022 Category: Drugs & Pharmacology Authors: Francis Kalemeera, Brian Godman, Andy Stergachis, Tim Rennie Tags: ORIGINAL ARTICLE Source Type: research

MG53: A potential therapeutic target for kidney disease
Currently, treatments to attenuate kidney diseases are still limited, especially for patients with stages 3-5 CKD. After reviewing recent studies, we found that MG53 plays an important role in both AKI and CKD. Its critical function as a membrane repair protein has been clearly demonstrated in PTECs. Moreover, it also appears to mediate the renoprotective effects of several acute kidney injuries and chronic kidney diseases, which may provide new approaches to the treatment of kidney disease. AbstractEnsuring cell survival and tissue regeneration by maintaining cellular integrity is important to the pathophysiology of many ...
Source: Pharmacology Research and Perspectives - December 30, 2022 Category: Drugs & Pharmacology Authors: Ben Ke, Wen Shen, Jianling Song, Xiangdong Fang Tags: REVIEW Source Type: research

Autocrine EGF and TGF ‐α promote primary and acquired resistance to ALK/c‐Met kinase inhibitors in non‐small‐cell lung cancer
Primary and acquired resistance to tyrosine kinase inhibitors (TKIs) causes treatment failure in NSCLC. The molecular mechanism of drug resistance to TKIs remains largely unknown. We demonstrate that autocrine EGF and TGF- α confer primary and acquired resistance to ALK/c-Met TKIs in NSCLC. These findings suggest that close attention should be paid to the expression changes of growth factors in patients before and after treatment. AbstractDrug resistance severely limits the clinical therapeutic value of molecularly targeted drugs. Growth factors gain a tremendous amount of focus due to the ability to promote drug resistan...
Source: Pharmacology Research and Perspectives - December 30, 2022 Category: Drugs & Pharmacology Authors: Yueqin Wang, Yu Zhang, Ruiying Chen, Xin Tian Tags: ORIGINAL ARTICLE Source Type: research

Xanthatin suppresses proliferation and tumorigenicity of glioma cells through autophagy inhibition via activation of the PI3K ‐Akt–mTOR pathway
In this study, we report that xanthatin suppressed glioma cells proliferation and induced apoptosis in a time- and concentration-dependent manner, and was accompanied by autophagy inhibition displaying a significantly reduced LC3 punctate fluorescence and LC3II/I ratio, decreased level of Beclin 1, while increased accumulation of p62. Notably, treating glioma cells with xanthatin resulted in obvious activation of the PI3K-Akt –mTOR signaling pathway, as indicated by increased mTOR and Akt phosphorylation, decreased ULK1 phosphorylation, which is important in modulating autophagy. Furthermore, xanthatin-mediated pro-apopt...
Source: Pharmacology Research and Perspectives - December 27, 2022 Category: Drugs & Pharmacology Authors: Huaqing Chen, Tong Zhu, Xiaojie Huang, Wenshuang Xu, Zemin Di, Yuyang Ma, Min Xue, Sixing Bi, Yujun Shen, Yongqiang Yu, Yuxian Shen, Lijie Feng Tags: INVITED REVIEW Source Type: research

The effect of Fingolimod on patients with moderate to severe COVID ‐19
Fingolimod could reduce the re-admission rate after hospitalization with COVID-19. AbstractHyper-inflammation, cytokine storm, and recruitment of immune cells lead to uncontrollable endothelial cell damage in patients with coronavirus disease 2019 (COVID-19). Sphingosine 1-phosphate (S1P) signaling is needed for endothelial integrity and its decreased serum level is a predictor of clinical severity in COVID-19. In this clinical trial, the effect of Fingolimod, an agonist of S1P, was evaluated on patients with COVID-19. Forty patients with moderate to severe COVID-19 were enrolled and divided into two groups including (1) t...
Source: Pharmacology Research and Perspectives - December 26, 2022 Category: Drugs & Pharmacology Authors: Soheil Teymouri, Siamak Pourbayram Kaleybar, Seyyed Sina Hejazian, Seyyedeh Mina Hejazian, Khalil Ansarin, Mohammadreza Ardalan, Sepideh Zununi Vahed Tags: ORIGINAL ARTICLE Source Type: research

Pattern and predictors of medication use among adults in southwestern Nigeria: A community ‐based cross‐sectional study
Pattern and Predictors of Medication Use among Adults in Southwestern Nigeria: A Community-based Cross-sectional study. AbstractPopulation-based drug utilization studies are scanty in Nigeria. The aim was to determine the pattern and predictors of medication use among adults in the communities of Southwestern Nigeria. A cross-sectional study was conducted among adults selected by multi-stage sampling from Oyo State communities. The questionnaires, adapted from the WHO Students' Drug Use Questionnaire and previous studies, were pretested and interviewer administered. The respondents' socio-demographic characteristics, the p...
Source: Pharmacology Research and Perspectives - December 25, 2022 Category: Drugs & Pharmacology Authors: Waheed Adeola Adedeji, Magbagbeola David Dairo, Patrick Mboya Nguku, Akin Oyemakinde, Fatai Adewale Fehintola Tags: ORIGINAL ARTICLE Source Type: research

Prediction of milk plasma ratio for amphoteric substances
(Source: Pharmacology Research and Perspectives)
Source: Pharmacology Research and Perspectives - December 24, 2022 Category: Drugs & Pharmacology Authors: Sabrina Jones, Fatimah Al ‐Doori, Ryoichi Fujiwara Tags: COMMENTARY Source Type: research