Pharmacology Research and Perspectives This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Exploring Australian pharmacists' views toward reducing the risk of medicines ‐related harm in aged care residents
This study aimed to explore Australian pharmacists' views toward reducing the risk of medicines-related harm in older residents. Qualitative, semi-structured interviews were conducted with 15 Pharmacists across Australia providing services (e.g., through the provision of medication reviews, supplying medications, or being an embedded pharmacist) to RACFs identified via convenience sampling. Data were analyzed by thematic analysis using an inductive approach. Medicines-related harm was thought to occur due to polypharmacy, inappropriate medicines, anticholinergic activity, sedative load, and lack of reconciliation of medici...
Source: Pharmacology Research and Perspectives - May 24, 2023 Category: Drugs & Pharmacology Authors: Sheraz Ali, Colin M. Curtain, Gregory M. Peterson, Mohammed S. Salahudeen Tags: ORIGINAL ARTICLE Source Type: research

Effect of a high ‐fat and high‐calorie food on the pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy subjects
This study demonstrated that HSK16149 can be administered with or without food. (Source: Pharmacology Research and Perspectives)
Source: Pharmacology Research and Perspectives - May 20, 2023 Category: Drugs & Pharmacology Authors: Qingqing Wu, Huijuan Zhu, Rong Song, Mengqi Zhang, Fangqiong Li, Weifang Zeng, Wei Wang, Jingying Jia, Chen Yu, Yanmei Liu Tags: ORIGINAL ARTICLE Source Type: research

Survey analysis and discussion on cultivating scientific research quality among undergraduates in medical colleges
AbstractTo explore rational measures to improve medical undergraduates' scientific research quality by investigating and analyzing their scientific research situation. A questionnaire survey was conducted in March 2022 among medical college/university undergraduates across four grades and five majors. Five hundred and ninety-four questionnaires were distributed, and 553 valid copies were returned, with a 93.1% return rate. The results showed that 61.5% of the students had an intense interest in research experiments, and 46.8% thought it was important for undergraduates to participate in research experiments, but only 17.5%...
Source: Pharmacology Research and Perspectives - May 19, 2023 Category: Drugs & Pharmacology Authors: Ling Liu, Jing Luan Tags: ORIGINAL ARTICLE Source Type: research

Novel oral SPT inhibitor CH5169356 inhibits hepatic stellate cell activation and ameliorates hepatic fibrosis in mouse models of non ‐alcoholic steatohepatitis (NASH)
In conclusion, CH5169356 could inhibit the progression of hepatic fibrosis in the pathogenesis of NASH by suppressing HSC activation, suggesting that CH5169356 would be a potential oral NASH therapeutic agent. (Source: Pharmacology Research and Perspectives)
Source: Pharmacology Research and Perspectives - May 19, 2023 Category: Drugs & Pharmacology Authors: Natsuko Hada, Asao Katsume, Kawasaki Kenichi, Chihiro Endo, Naoshi Horiba, Masayuki Sudoh Tags: ORIGINAL ARTICLE Source Type: research

Endoplasmic reticulum stress in the adipose tissue and monocyte chemoattractant protein ‐1 are involved in tacrolimus‐induced diabetes mellitus
In conclusion, tacrolimus-induced insulin resistance. Tacrolimus trough levels ≥10 ng/mL during the first 3 postoperative months were an independent risk factor for NODAT. ER stress and MCP-1 underlie tacro limus-induced diabetes. (Source: Pharmacology Research and Perspectives)
Source: Pharmacology Research and Perspectives - May 18, 2023 Category: Drugs & Pharmacology Authors: Xiaoxia Sun, Hongyang Wang, Jingwei Chi, Kui Che, Yangang Wang Tags: ORIGINAL ARTICLE Source Type: research

Rapamycin treatment increases survival, autophagy biomarkers and expression of the anti ‐aging klotho protein in elderly mice
AbstractPrevious investigations have demonstrated that treatment of animals with rapamycin increases levels of autophagy, which is a process by which cells degrade intracellular detritus, thus suppressing the emergence of senescent cells, whose pro-inflammatory properties, are primary drivers of age-associated physical decline. A hypothesis is tested here that rapamycin treatment of mice approaching the end of their normal lifespan exhibits increased survival, enhanced expression of autophagic proteins; and klotho protein —a biomarker of aging that affects whole organism senescence, and systemic suppression of inflammato...
Source: Pharmacology Research and Perspectives - May 16, 2023 Category: Drugs & Pharmacology Authors: Kitti Sz őke, Beáta Bódi, Zoltán Hendrik, Attila Czompa, Alexandra Gyöngyösi, Donald David Haines, Zoltán Papp, Árpád Tósaki, István Lekli Tags: ORIGINAL ARTICLE Source Type: research

JP ‐1366: A novel and potent potassium‐competitive acid blocker that is effective in the treatment of acid‐related diseases
Plasma pharmacokinetics parameters of JP-1366 and TAK-438 obtained following a single oral dose of JP-1366 in male SD rats. AbstractThe global prevalence of GERD is substantially increasing each year, and GERD is a chronic disease that reduces the quality of life of patients. The efficacy of conventional drugs is diverse, and most require long-term or lifetime administration; thus, the development of more effective therapeutic agents is needed. Herein, a more effective treatment for GERD was tested. We investigated whether JP-1366 affected gastric H+/K+-ATPase activity and used the Na+/K+-ATPase assay to confirm the select...
Source: Pharmacology Research and Perspectives - May 6, 2023 Category: Drugs & Pharmacology Authors: Jin Mo Ku, Jin Hee Cho, Kangjeon Kim, Ji Yoon Kim, Jong Yup Kim, John Kim, Hyunju Cha, Banyoon Cheon Tags: ORIGINAL ARTICLE Source Type: research

The influence of SARS ‐CoV‐2 infection on expression of drug‐metabolizing enzymes and transporters in a hACE2 murine model
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting Coronavirus disease 2019 emerged in late 2019 and is responsible for significant morbidity and mortality worldwide. A hallmark of severe COVID-19 is exaggerated systemic inflammation, regarded as a “cytokine storm,” which contributes to the damage of various organs, primarily the lungs. The inflammation associated with some viral illnesses is known to alter the expression of drug-metabolizing enzymes and transporters. These alterations can lead to modifications in drug exposure and the pro cessing of various endogenous comp...
Source: Pharmacology Research and Perspectives - May 4, 2023 Category: Drugs & Pharmacology Authors: Kiran Deshpande, Keith R. Lange, William B. Stone, Christine Yohn, Naomi Schlesinger, Leonid Kagan, Albert J. Auguste, Bonnie L. Firestein, Luigi Brunetti Tags: ORIGINAL ARTICLE Source Type: research