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Suspected oncologic adverse reactions associated with interleukin ‐23 inhibitors in EudraVigilance: Comparative study and gender distribution
This study investigated the occurrence of malignancies as suspected adverse reactions (SARs) potentially associated with IL-23 inhibitors by analyzing real-world data from the European EudraVigilance database. Although indicatory, these real-world data seem to confirm the potential association between the IL-23 inhibitors risankizumab and tildrakizumab, and the occurrence of SARs linked to cancer in patients with psoriasis and, according to a gender perspective, they show that this relationship is asymmetrically distributed between women and men, with a clear prevalence of oncologic SARs in men. (Source: Pharmacology Resea...
Source: Pharmacology Research and Perspectives - August 24, 2023 Category: Drugs & Pharmacology Authors: Fabrizio Calapai, Carmen Mannucci, Luigi Cardia, Mariaconcetta Curr ò, Gioacchino Calapai, Emanuela Esposito, Ilaria Ammendolia Tags: SHORT REPORT Source Type: research

Evaluating adverse events in databases
(Source: Pharmacology Research and Perspectives)
Source: Pharmacology Research and Perspectives - August 23, 2023 Category: Drugs & Pharmacology Authors: Katie Lovell, Steven R. Feldman Tags: COMMENTARY Source Type: research

Effects of pharmacological doses of niacin on subacute glucocorticoid ‐induced testicular damage in rats
In conclusion, niacin administration at pharmacological doses dose-dependently ameliorates t he destructive effects of dexamethasone on sperm motility, Johnsen score, and testicular cell apoptosis in rats with the latter can be considered a decisive mechanism for its positive effects on testis. (Source: Pharmacology Research and Perspectives)
Source: Pharmacology Research and Perspectives - August 17, 2023 Category: Drugs & Pharmacology Authors: E. Azimi  Zangabad, Tahoora Shomali, L. Roshangar Tags: ORIGINAL ARTICLE Source Type: research

Response to “Evaluating Adverse Events in Databases”
(Source: Pharmacology Research and Perspectives)
Source: Pharmacology Research and Perspectives - August 17, 2023 Category: Drugs & Pharmacology Authors: Fabrizio Calapai, Carmen Mannucci, Luigi Cardia, Mariaconcetta Curr ò, Gioacchino Calapai, Emanuela Esposito, Ilaria Ammendolia Tags: EDITORIAL Source Type: research

Issue Information
(Source: Pharmacology Research and Perspectives)
Source: Pharmacology Research and Perspectives - August 17, 2023 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research

Delineation of the distinct inflammatory signaling roles of TAK1 and JAK1/3 in the CIA model of rheumatoid arthritis
Differential expression of cytokines from TAK1 and JAK inhibited macrophages. AbstractRheumatoid arthritis (RA) is a complex autoimmune disease characterized by hyperactive immune cells within the joints, which leads to inflammation, bone degeneration, and chronic pain. For several decades, frontline immunomodulators such as the anti-tumor necrosis factor (TNF) biologics adalimumab (Humira), etanercept (Enbrel), and infliximab (Remicade) have successfully managed disease progression for many patients. However, over time, patients become refractory to these treatments requiring chronic disease to be managed with conventiona...
Source: Pharmacology Research and Perspectives - August 11, 2023 Category: Drugs & Pharmacology Authors: Robert Freeze, Kelly W. Yang, Timothy Haystead, Philip Hughes, Scott Scarneo Tags: ORIGINAL ARTICLE Source Type: research

Experimental training in molecular pharmacology education based on drug –target interactions
ConclusionThe designed experimental training program has a positive effect on the training of pharmacology talents, and can be implemented as a part of molecular pharmacology education. (Source: Pharmacology Research and Perspectives)
Source: Pharmacology Research and Perspectives - August 10, 2023 Category: Drugs & Pharmacology Authors: Luna Ge, Kai Cheng, Yuang Zhang, Junling Li, Wei Chen, Guanhua Song, Lin Wang Tags: ORIGINAL ARTICLE Source Type: research

Intravenous ibuprofen in postoperative pain and fever management in adults: A systematic review and meta ‐analysis of randomized controlled trials
In conclusion, moderate-to-low certainty evidence supports the use of IVIB for adults with postoperative pain and fever who are unable to take oral medications. (Source: Pharmacology Research and Perspectives)
Source: Pharmacology Research and Perspectives - August 3, 2023 Category: Drugs & Pharmacology Authors: Pengxiang Zhou, Lu Chen, Ente Wang, Lanzhi He, Shuxia Tian, Suodi Zhai Tags: REVIEW Source Type: research