Pharmacology Research and Perspectives This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Epigenetics in obesity: Mechanisms and advances in therapies based on natural products
XXXX AbstractObesity is a major risk factor for morbidity and mortality because it has a close relationship to metabolic illnesses, such as diabetes, cardiovascular diseases, and some types of cancer. With no drugs available, the mainstay of obesity management remains lifestyle changes with exercise and dietary modifications. In light of the tremendous disease burden and unmet therapeutics, fresh perspectives on pathophysiology and drug discovery are needed. The development of epigenetics provides a compelling justification for how environmental, lifestyle, and other risk factors contribute to the pathogenesis of obesity. ...
Source: Pharmacology Research and Perspectives - January 31, 2024 Category: Drugs & Pharmacology Authors: Peng Chen, Yulai Wang, Fuchao Chen, Benhong Zhou Tags: REVIEW Source Type: research

Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients
Serum vitamin B6 level was strongly correlated with total levodopa dose in PD patients. AbstractThe study aims to investigate the vitamin B6 levels in Parkinson's disease (PD) patients and their association with liver enzymes and evaluate how much dysregulation is associated with levodopa dose. Furthermore, to evaluate the effect of Opicapone, a catechol-o-methyl-transferase inhibitor, on vitamin B6 levels by monitoring the AST and ALT levels in patients treated with Levodopa –Carbidopa Intestinal Gel Infusion (LCIG). For these aims, serum vitamin B6 levels were measured (PD,n = 72 and controls,n = 31). The vitam...
Source: Pharmacology Research and Perspectives - January 30, 2024 Category: Drugs & Pharmacology Authors: Kensuke Ikenaka, Yuta Kajiyama, C ésar Aguirre, Chi‐Jing Choong, Seira Taniguchi, Junko Doi, Nan Wang, Takahiro Ajiki, Kotaro Ogawa, Keita Kakuda, Yasuyoshi Kimura, Hideki Mochizuki Tags: ORIGINAL ARTICLE Source Type: research

The impact of phosphodiesterase ‐5 inhibition or angiotensin‐converting enzyme inhibition on right and left ventricular remodeling in heart failure due to chronic volume overload
Despite elevated cGMP levels in the lungs of sildenafil-treated rats, PDE5i did not improve survival rate and did not change the cardiac and renal function of ACF rats with advanced HF. In contrast, mortality in the ACF model was reduced by ACEi treatment. AbstractWhile phosphodiesterase-5 inhibition (PED5i) may prevent hypertrophy and failure in pressure-overloaded heart in an experimental model, the impact of PDE5i on volume-overload (VO)-induced hypertrophy is unknown. It is also unclear whether the hypertrophied right ventricle (RV) and left ventricle (LV) differ in their responsiveness to long-term PDE5i and if this t...
Source: Pharmacology Research and Perspectives - January 29, 2024 Category: Drugs & Pharmacology Authors: Tereza Tykvartova, Matus Miklovic, Martin Kotrc, Petra Skaroupkova, Ludmila Kazdova, Jaroslava Trnovska, Vojtech Skop, Michal Kolar, Jiri Novotny, Vojtech Melenovsky Tags: ORIGINAL ARTICLE Source Type: research

Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients
Serum vitamin B6 level was strongly correlated with total levodopa dose in PD patients. AbstractThe study aims to investigate the vitamin B6 levels in Parkinson's disease (PD) patients and their association with liver enzymes and evaluate how much dysregulation is associated with levodopa dose. Furthermore, to evaluate the effect of Opicapone, a catechol-o-methyl-transferase inhibitor, on vitamin B6 levels by monitoring the AST and ALT levels in patients treated with Levodopa –Carbidopa Intestinal Gel Infusion (LCIG). For these aims, serum vitamin B6 levels were measured (PD,n = 72 and controls,n = 31). The vitam...
Source: Pharmacology Research and Perspectives - January 29, 2024 Category: Drugs & Pharmacology Authors: Kensuke Ikenaka, Yuta Kajiyama, C ésar Aguirre, Chi‐Jing Choong, Seira Taniguchi, Junko Doi, Nan Wang, Takahiro Ajiki, Kotaro Ogawa, Keita Kakuda, Yasuyoshi Kimura, Hideki Mochizuki Tags: ORIGINAL ARTICLE Source Type: research

Scopolamine regulates the osteogenic differentiation of human periodontal ligament stem cells through lactylation modification of RUNX2 protein
Scopolamine regulates the osteogenic differentiation of human periodontal ligament stem cells through modulating the lactylation and ubiquitination modification of RUNX2 protein AbstractPeriodontal ligament stem cells (PDLSCs) are important mesenchymal stem cells contributing to regenerating lost periodontal tissues and repairing bone defects. Studies on the molecular mechanism affecting the osteogenic differentiation of PDLSCs are necessary. Scopolamine (SCO) is known as a regulator of neural cell damage. The focus of the current study is on unveiling the role of SCO-mediated molecular mechanism in the osteogenic differen...
Source: Pharmacology Research and Perspectives - January 24, 2024 Category: Drugs & Pharmacology Authors: Ying Wu, Pan Gong Tags: ORIGINAL ARTICLE Source Type: research

Development of a pharmaceutical science systematic review process using a semi ‐automated machine learning tool: Intravenous drug compatibility in the neonatal intensive care setting
Overview of systematic review search, screening and selection process. AbstractOur objective was to establish and test a machine learning-based screening process that would be applicable to systematic reviews in pharmaceutical sciences. We used the SPIDER (Sample, Phenomenon of Interest, Design, Evaluation, Research type) model, a broad search strategy, and a machine learning tool (Research Screener) to identify relevant references related to y-site compatibility of 95 intravenous drugs used in neonatal intensive care settings. Two independent reviewers conducted pilot studies, including manual screening and evaluation of ...
Source: Pharmacology Research and Perspectives - January 11, 2024 Category: Drugs & Pharmacology Authors: D. Thisuri N. De Silva, Brioni R. Moore, Tobias Strunk, Michael Petrovski, Vanessa Varis, Kevin Chai, Leo Ng, Kevin T. Batty Tags: ORIGINAL ARTICLE Source Type: research

A systematic review on experimental studies about patient adherence to treatment
AbstractA better understanding of patients' adherence to treatment is a prerequisite to maximize the benefit of healthcare provision for patients, reduce treatment costs, and is a key factor in a variety of subsequent health outcomes. We aim to understand the state of the art of scientific evidence about which factors influence patients' adherence to treatment. A systematic literature review was conducted using PRISMA guidelines in five separate electronic databases of scientific publications: PubMed, PsycINFO (ProQuest), Cochrane library (Ovid), Google Scholar, and Web of Science. The search focused on literature reportin...
Source: Pharmacology Research and Perspectives - January 11, 2024 Category: Drugs & Pharmacology Authors: Frans Folkvord, Ana Roca ‐Umbert Würth, Karlijn van Houten, Aad R. Liefveld, Jim Ingebretsen Carlson, Nadine Bol, Emiel Krahmer, Gwenn Beets, Rachel Drbohlav Ollerton, Eva Turk, Harald Hrubos‐Strøm, Hamza Nahoui, Gunnar Einvik, Henrik S Tags: ORIGINAL ARTICLE Source Type: research

Real ‐world treatment outcomes of immune checkpoint inhibitors used off‐label in oncology: A comprehensive cancer institution experience
This study aimed to evaluate the overall survival (OS), event-free survival (EFS), duration of treatment (DOT), and reason for treatment discontinuation in patients receiving immune checkpoint inhibitors (ICI) as OLU for solid tumors from 2011 to 2020. The study collected data on 356 episodes (353 patients), with a median age of 64.4 years, 36.2% women, and 14.6% ECOG ≥ 2. Median OS was 15.7 (11.9–18.7) months, and median EFS was 5.4 (3.8–6.6) months. Men, patients with metastatic disease or ECOG-PS higher than 1, had worse survival outcomes. The findings derived from this study provide valuable information rega...
Source: Pharmacology Research and Perspectives - January 10, 2024 Category: Drugs & Pharmacology Authors: Sandra Fontanals, Anna Esteve, Andrea Gonz ález, Cristina Ibáñez, Ricard Mesía, Ana Clopés Tags: SHORT REPORT Source Type: research

Antioxidant potential of chlorogenic acid in Age ‐Related eye diseases
AbstractOxidative stress is an important mechanism of aging, and in turn, aging can also aggravate oxidative stress, which leads to a vicious cycle. In the process of the brain converting light into visual signals, the eye is stimulated by harmful blue-light radiation directly. Thus, the eye is especially vulnerable to oxidative stress and becomes one of the organs most seriously involved during the aging process. Cataracts, age-related macular degeneration (AMD), glaucoma, diabetic retinopathy (DR), and dry eye are inextricably linked to the aging process and oxidative stress. Chlorogenic acid (CGA) has been demonstrated ...
Source: Pharmacology Research and Perspectives - January 9, 2024 Category: Drugs & Pharmacology Authors: Yu Tang, Chi Fang, Jian Shi, Huimei Chen, Xiong Chen, Xiaolei Yao Tags: REVIEW Source Type: research

Real ‐world treatment outcomes of immune checkpoint inhibitors used off‐label in oncology: A comprehensive cancer institution experience
This study aimed to evaluate the overall survival (OS), event-free survival (EFS), duration of treatment (DOT), and reason for treatment discontinuation in patients receiving immune checkpoint inhibitors (ICI) as OLU for solid tumors from 2011 to 2020. The study collected data on 356 episodes (353 patients), with a median age of 64.4 years, 36.2% women, and 14.6% ECOG ≥ 2. Median OS was 15.7 (11.9–18.7) months, and median EFS was 5.4 (3.8–6.6) months. Men, patients with metastatic disease or ECOG-PS higher than 1, had worse survival outcomes. The findings derived from this study provide valuable information rega...
Source: Pharmacology Research and Perspectives - January 9, 2024 Category: Drugs & Pharmacology Authors: Sandra Fontanals, Anna Esteve, Andrea Gonz ález, Cristina Ibáñez, Ricard Mesía, Ana Clopés Tags: SHORT REPORT Source Type: research

Antioxidant potential of chlorogenic acid in Age ‐Related eye diseases
AbstractOxidative stress is an important mechanism of aging, and in turn, aging can also aggravate oxidative stress, which leads to a vicious cycle. In the process of the brain converting light into visual signals, the eye is stimulated by harmful blue-light radiation directly. Thus, the eye is especially vulnerable to oxidative stress and becomes one of the organs most seriously involved during the aging process. Cataracts, age-related macular degeneration (AMD), glaucoma, diabetic retinopathy (DR), and dry eye are inextricably linked to the aging process and oxidative stress. Chlorogenic acid (CGA) has been demonstrated ...
Source: Pharmacology Research and Perspectives - January 8, 2024 Category: Drugs & Pharmacology Authors: Yu Tang, Chi Fang, Jian Shi, Huimei Chen, Xiong Chen, Xiaolei Yao Tags: REVIEW Source Type: research