Pharmacology Research and Perspectives This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Reported hepatotoxicity and hepatotoxicity guidance in the product information of protein kinase inhibitors in oncology registered at the European Medicines Agency
AbstractProtein kinase inhibitors (PKIs) used in oncology can induce severe and even fatal hepatotoxicity. Several PKIs are registered within a certain class to target a specific kinase. No systematic comparison of the reported hepatotoxicity and clinical guidance for monitoring and management of hepatotoxic events between the various PKI summaries of product characteristics (SmPC) is yet available. A systematic analysis of data on 21 hepatotoxicity parameters obtained from the SmPCs and European public assessment reports (EPARs) of European Medicines Agency-approved antineoplastic PKIs (n = 55) has been conducted. The m...
Source: Pharmacology Research and Perspectives - February 27, 2023 Category: Drugs & Pharmacology Authors: Marc Maliepaard, Yoran S. Faber, Mark T. J. Bussel Tags: ORIGINAL ARTICLE Source Type: research

Highlights of basic and clinical pharmacology from Africa
(Source: Pharmacology Research and Perspectives)
Source: Pharmacology Research and Perspectives - February 27, 2023 Category: Drugs & Pharmacology Authors: Vanessa Steenkamp Tags: EDITORIAL Source Type: research

Safety, tolerability, and pharmacokinetics of a single ascending subcutaneous dose of GSK3772847 in healthy participants
AbstractThe aim of this study was to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of GSK3772847, compared with placebo administered subcutaneously (SC) in healthy participants, including cohorts of Japanese and Chinese participants. This was a single-center, randomized, placebo-controlled, double-blind, single ascending dose study. Following a screening period of up to 28 days, eligible participants were assigned to one of four cohorts receiving a single dose of GSK3772847 70 mg (cohort 1) or 140 mg (cohorts 2, 3, and 4) or placebo SC. In cohorts 1 and 2, participants were rand...
Source: Pharmacology Research and Perspectives - February 27, 2023 Category: Drugs & Pharmacology Authors: Eleni Pefani, Sally Stone, Chang ‐Qing Zhu, Carol Nunn, David Fairman Tags: ORIGINAL ARTICLE Source Type: research

Lower sertraline plasma concentration in patients co ‐medicated with clozapine—Implications for pharmacological augmentation strategies in schizophrenia
AbstractAugmentation of antipsychotic treatment with antidepressants represents a common and beneficial treatment strategy in patients suffering from schizophrenia. Combining clozapine and the selective serotonin reuptake inhibitor (SSRI) sertraline represents a clinically important strategy in patients with therapy-resistant schizophrenia, but there is limited knowledge about mutual pharmacokinetic interactions. In the present study, we assessed the impact of clozapine on sertraline plasma concentrations. Based on a therapeutic drug monitoring (TDM) database, sertraline plasma concentrations were compared between two grou...
Source: Pharmacology Research and Perspectives - February 25, 2023 Category: Drugs & Pharmacology Authors: Arnim Johannes Gaebler, Ekkehard Haen, Nagia Ben Omar, Katharina Endres, Christoph Hiemke, Georgios Schoretsanitis, Michael Paulzen Tags: ORIGINAL ARTICLE Source Type: research

Clinical effect of different doses of ciprofol for induction of general anesthesia in elderly patients: A randomized, controlled trial
Ciprofol at a dose of 0.3 mg/kg has good safety and efficacy in the induction of general anesthesia in elderly patients. AbstractCiprofol is a newly developed intravenous anesthetic agent with improved pharmacokinetic properties. Compared to propofol, ciprofol exhibits stronger binding to the GABAA receptor and elicits a greater enhancement of GABAA receptor-mediated neuronal currents in vitro. The aims of the present clinical trials were to examine the safety and efficacy of different doses of ciprofol for induction of general anesthesia in elderly patients. A total of 105 elderly patients undergoing elective surgery were...
Source: Pharmacology Research and Perspectives - February 23, 2023 Category: Drugs & Pharmacology Authors: Gongchen Duan, Haiyan Lan, Weifeng Shan, Yini Wu, Qiaomin Xu, Xiaoli Dong, Peiyi Mei, Minji You, Linfei Jin, Jimin Wu Tags: ORIGINAL ARTICLE Source Type: research

Pros and cons for statins use and risk of Parkinson's disease: An updated perspective
In conclusion, there are strong controversies regarding the protective role of statins in PD neuropathology. Therefore, retrospective and prospective studies are necessary in this regard. (Source: Pharmacology Research and Perspectives)
Source: Pharmacology Research and Perspectives - February 22, 2023 Category: Drugs & Pharmacology Authors: Hayder M. Al ‐kuraishy, Ali I. Al‐Gareeb, Athanasios Alexiou, Marios Papadakis, Abdulrahman A. Alsayegh, Najlaa Hamed Almohmadi, Hebatallah M. Saad, Gaber El‐Saber Batiha Tags: REVIEW Source Type: research

Synergism of amlodipine and telmisartan or candesartan on blood pressure reduction by using SynergyFinder 3.0 and probability sum test in vivo
This study was designed to evaluate the synergism of two couples of antihypertensive drugs (amlodipine + telmisartan and amlodipine + candesartan) on blood pressure reduction in vivo by both SynergyFinder 3.0 and probability sum test. Spontaneously hypertensive rats were treated with intragastric administration of amlodipine (0.5, 1, 2, and 4 mg/kg), telmisartan (4, 8, and 16 mg/kg), cand esartan (1, 2, and 4 mg/kg), nine combinations for amlodipine and telmisartan, and nine combinations for amlodipine and candesartan. The control rats were treated by 0.5% carboxymethylcellulose sodium. Blood pressure was reco...
Source: Pharmacology Research and Perspectives - February 22, 2023 Category: Drugs & Pharmacology Authors: Tian Xia, Lu ‐Lu Xu, Peng‐Yue Guo, Wan‐Ting Shi, Yan‐Qiong Cheng, Ai‐Jun Liu Tags: ORIGINAL ARTICLE Source Type: research

Clinical effect of different doses of ciprofol for induction of general anesthesia in elderly patients: A randomized, controlled trial
Ciprofol at a dose of 0.3 mg/kg has good safety and efficacy in the induction of general anesthesia in elderly patients. AbstractCiprofol is a newly developed intravenous anesthetic agent with improved pharmacokinetic properties. Compared to propofol, ciprofol exhibits stronger binding to the GABAA receptor and elicits a greater enhancement of GABAA receptor-mediated neuronal currents in vitro. The aims of the present clinical trials were to examine the safety and efficacy of different doses of ciprofol for induction of general anesthesia in elderly patients. A total of 105 elderly patients undergoing elective surgery were...
Source: Pharmacology Research and Perspectives - February 22, 2023 Category: Drugs & Pharmacology Authors: Gongchen Duan, Haiyan Lan, Weifeng Shan, Yini Wu, Qiaomin Xu, Xiaoli Dong, Peiyi Mei, Minji You, Linfei Jin, Jimin Wu Tags: ORIGINAL ARTICLE Source Type: research

Mechanistic in vitro studies indicate that the clinical drug –drug interactions between protease inhibitors and rosuvastatin are driven by inhibition of intestinal BCRP and hepatic OATP1B1 with minimal contribution from OATP1B3, NTCP and OAT3
This work sought to clarify the mechanisms underlying clinical DDIs between rosuvastatin and protease inhibitors. Investigating in vitro inhibition of the critical transporter disposition pathways of rosuvastatin, and subsequent incorporation of cell test system derived determined Ki values into mechanistic static equations, enabled successful quantitative prediction of clinical AUCRs. Predictions suggest the mechanisms driving DDI are principally inhibition of intestinal BCRP and hepatic OATP1B1, with minimal contribution from OATP1B3, NTCP or OAT3. AbstractPrevious use of a mechanistic static model to accurately quantify...
Source: Pharmacology Research and Perspectives - February 22, 2023 Category: Drugs & Pharmacology Authors: Robert Elsby, Hannah Coghlan, Jacob Edgerton, David Hodgson, Samuel Outteridge, Hayley Atkinson Tags: ORIGINAL ARTICLE Source Type: research

Defined daily doses in pediatric dosing ‐ a theoretical example
Calculated daily doses from the Summary of product characteristics (SmPC) for paracetamol to children by age group and sex. The bars represent the dose for average weight and the whiskers +/ − 2 standard deviations from the average weight. AbstractA defined daily dose for children (cDDD) taking body weight into account, was proposed as a better measure of drug utilization in children than the World Health Organization's DDD. There is no global definition of DDDs for children, and it is unclear which standard doses should be used for children when conducting drug utilization studies. We used doses according to the authori...
Source: Pharmacology Research and Perspectives - February 20, 2023 Category: Drugs & Pharmacology Authors: Elin Dahl én, Jenny Marianne Kindblom, Elin Eyfells Kimland Tags: SHORT REPORT Source Type: research